Sandra Siegert
Siegert Group
22 Publications
2023 | Epub ahead of print | Journal Article | IST-REx-ID: 14257 |
Michalska JM, Lyudchik J, Velicky P, et al. Imaging brain tissue architecture across millimeter to nanometer scales. Nature Biotechnology. 2023. doi:10.1038/s41587-023-01911-8
[Published Version]
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| Files available
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| Download Published Version (ext.)
| WoS
2023 | Published | Journal Article | IST-REx-ID: 14363 |
Maes ME, Colombo G, Schoot Uiterkamp FE, et al. Mitochondrial network adaptations of microglia reveal sex-specific stress response after injury and UCP2 knockout. iScience. 2023;26(10). doi:10.1016/j.isci.2023.107780
[Published Version]
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| Files available
| DOI
| WoS
| PubMed | Europe PMC
2022 | Published | Journal Article | IST-REx-ID: 12244 |
Colombo G, Cubero RJ, Kanari L, et al. A tool for mapping microglial morphology, morphOMICs, reveals brain-region and sex-dependent phenotypes. Nature Neuroscience. 2022;25(10):1379-1393. doi:10.1038/s41593-022-01167-6
[Published Version]
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| Files available
| DOI
| WoS
| PubMed | Europe PMC
2022 | Published | Journal Article | IST-REx-ID: 11478 |
Bartalska K, Hübschmann V, Korkut M, et al. A systematic characterization of microglia-like cell occurrence during retinal organoid differentiation. iScience. 2022;25(7). doi:10.1016/j.isci.2022.104580
[Published Version]
View
| Files available
| DOI
| WoS
2022 | Submitted | Preprint | IST-REx-ID: 11950 |
Michalska JM, Lyudchik J, Velicky P, et al. Uncovering brain tissue architecture across scales with super-resolution light microscopy. bioRxiv. doi:10.1101/2022.08.17.504272
[Preprint]
View
| Files available
| DOI
| Download Preprint (ext.)
2022 | Published | Journal Article | IST-REx-ID: 11995 |
Schulz R, Korkut M, Venturino A, Colombo G, Siegert S. Chimeric GPCRs mimic distinct signaling pathways and modulate microglia responses. Nature Communications. 2022;13. doi:10.1038/s41467-022-32390-1
[Published Version]
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| Files available
| DOI
| WoS
| PubMed | Europe PMC
2022 | Published | Journal Article | IST-REx-ID: 12117 |
Hübschmann V, Korkut M, Siegert S. Assessing human iPSC-derived microglia identity and function by immunostaining, phagocytosis, calcium activity, and inflammation assay. STAR Protocols. 2022;3(4). doi:10.1016/j.xpro.2022.101866
[Published Version]
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| Files available
| DOI
2021 | Published | Journal Article | IST-REx-ID: 9642 |
Venturino A, Schulz R, De Jesús-Cortés H, et al. Microglia enable mature perineuronal nets disassembly upon anesthetic ketamine exposure or 60-Hz light entrainment in the healthy brain. Cell Reports. 2021;36(1). doi:10.1016/j.celrep.2021.109313
[Published Version]
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| Files available
| DOI
| WoS
| PubMed | Europe PMC
2021 | Published | Journal Article | IST-REx-ID: 10565 |
Venturino A, Siegert S. Minimally invasive protocols and quantification for microglia-mediated perineuronal net disassembly in mouse brain. STAR Protocols. 2021;2(4). doi:10.1016/j.xpro.2021.101012
[Published Version]
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| Files available
| DOI
2021 | Published | Journal Article | IST-REx-ID: 10655 |
Maes ME, Wögenstein GM, Colombo G, Casado Polanco R, Siegert S. Optimizing AAV2/6 microglial targeting identified enhanced efficiency in the photoreceptor degenerative environment. Molecular Therapy - Methods and Clinical Development. 2021;23:210-224. doi:10.1016/j.omtm.2021.09.006
[Published Version]
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| Files available
| DOI
| WoS
2019 | Published | Journal Article | IST-REx-ID: 6521 |
Maes ME, Colombo G, Schulz R, Siegert S. Targeting microglia with lentivirus and AAV: Recent advances and remaining challenges. Neuroscience Letters. 2019;707. doi:10.1016/j.neulet.2019.134310
[Published Version]
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| Files available
| DOI
| WoS
| PubMed | Europe PMC
2016 | Published | Journal Article | IST-REx-ID: 1253 |
Tsai L, Siegert S. How MicroRNAs Are involved in splitting the mind. JAMA Psychiatry. 2016;73(4):409-410. doi:10.1001/jamapsychiatry.2015.3144
[Submitted Version]
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| Files available
| DOI
| PubMed | Europe PMC
2016 | Published | Journal Article | IST-REx-ID: 1613 |
Mungenast A, Siegert S, Tsai L. Modeling Alzheimer’s disease with human induced pluripotent stem (iPS) cells. Molecular and Cellular Neuroscience. 2016;73:13-31. doi:doi:10.1016/j.mcn.2015.11.010
[Submitted Version]
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| Files available
| DOI
2015 | Published | Journal Article | IST-REx-ID: 1802
Siegert S, Seo J, Kwon E, et al. The schizophrenia risk gene product miR-137 alters presynaptic plasticity. Nature Neuroscience. 2015;18:1008-1016. doi:10.1038/nn.4023
View
| DOI
2015 | Published | Journal Article | IST-REx-ID: 1803
Rei D, Mason X, Seo J, et al. Basolateral amygdala bidirectionally modulates stress induced hippocampal learning and memory deficits through a p25/Cdk5-dependent pathway. PNAS. 2015;112(23):7291-7296. doi:10.1073/pnas.1415845112
View
| DOI
2012 | Published | Journal Article | IST-REx-ID: 1801
Siegert S, Cabuy E, Scherf B, et al. Transcriptional code and disease map for adult retinal cell types. Nature Neuroscience. 2012;15(3):487-495. doi:10.1038/nn.3032
View
| DOI
2010 | Published | Journal Article | IST-REx-ID: 1800
Busskamp V, Duebel J, Bálya D, et al. Genetic reactivation of cone photoreceptors restores visual responses in retinitis pigmentosa. Science. 2010;329(5990):413-417. doi:10.1126/science.1190897
View
| DOI
2009 | Published | Journal Article | IST-REx-ID: 1798
Siegert S, Scherf B, Del Punta K, Didkovsky N, Heintz N, Roska B. Genetic address book for retinal cell types. Nature Neuroscience. 2009;12(9):1197-1204. doi:10.1038/nn.2370
View
| DOI
2009 | Published | Journal Article | IST-REx-ID: 1799
Münch T, Da Silveira R, Siegert S, Viney T, Awatramani G, Roska B. Approach sensitivity in the retina processed by a multifunctional neural circuit. Nature Neuroscience. 2009;12(10):1308-1316. doi:10.1038/nn.2389
View
| DOI
2007 | Published | Journal Article | IST-REx-ID: 1797
Viney T, Bálint K, Hillier D, et al. Local retinal circuits of melanopsin-containing ganglion cells identified by transsynaptic viral tracing. Current Biology. 2007;17(11):981-988. doi:10.1016/j.cub.2007.04.058
View
| DOI
2006 | Published | Journal Article | IST-REx-ID: 1796
Siegert S, Schnierle P, Schnierle B. Novel anti-viral therapy: Drugs that block HIV entry at different target sites. Mini-Reviews in Medicinal Chemistry. 2006;6(5):557-562. doi:10.2174/138955706776876267
View
| DOI
2005 | Published | Journal Article | IST-REx-ID: 1795
Siegert S, Thaler S, Wagner R, Schnierle B. Assessment of HIV-1 entry inhibitors by MLV/HIV-1 pseudotyped vectors. AIDS Research and Therapy. 2005;2(1). doi:10.1186/1742-6405-2-7
View
| DOI
3 Grants
Microglia action towards neuronal circuit formation and function in health and disease (MICROGLIA-CIRCUIT)
2017-05-01 – 2022-04-30
EC/H2020
2023-01-09 – 2026-31-08
FWF
HE_ERC
22 Publications
2023 | Epub ahead of print | Journal Article | IST-REx-ID: 14257 |
Michalska JM, Lyudchik J, Velicky P, et al. Imaging brain tissue architecture across millimeter to nanometer scales. Nature Biotechnology. 2023. doi:10.1038/s41587-023-01911-8
[Published Version]
View
| Files available
| DOI
| Download Published Version (ext.)
| WoS
2023 | Published | Journal Article | IST-REx-ID: 14363 |
Maes ME, Colombo G, Schoot Uiterkamp FE, et al. Mitochondrial network adaptations of microglia reveal sex-specific stress response after injury and UCP2 knockout. iScience. 2023;26(10). doi:10.1016/j.isci.2023.107780
[Published Version]
View
| Files available
| DOI
| WoS
| PubMed | Europe PMC
2022 | Published | Journal Article | IST-REx-ID: 12244 |
Colombo G, Cubero RJ, Kanari L, et al. A tool for mapping microglial morphology, morphOMICs, reveals brain-region and sex-dependent phenotypes. Nature Neuroscience. 2022;25(10):1379-1393. doi:10.1038/s41593-022-01167-6
[Published Version]
View
| Files available
| DOI
| WoS
| PubMed | Europe PMC
2022 | Published | Journal Article | IST-REx-ID: 11478 |
Bartalska K, Hübschmann V, Korkut M, et al. A systematic characterization of microglia-like cell occurrence during retinal organoid differentiation. iScience. 2022;25(7). doi:10.1016/j.isci.2022.104580
[Published Version]
View
| Files available
| DOI
| WoS
2022 | Submitted | Preprint | IST-REx-ID: 11950 |
Michalska JM, Lyudchik J, Velicky P, et al. Uncovering brain tissue architecture across scales with super-resolution light microscopy. bioRxiv. doi:10.1101/2022.08.17.504272
[Preprint]
View
| Files available
| DOI
| Download Preprint (ext.)
2022 | Published | Journal Article | IST-REx-ID: 11995 |
Schulz R, Korkut M, Venturino A, Colombo G, Siegert S. Chimeric GPCRs mimic distinct signaling pathways and modulate microglia responses. Nature Communications. 2022;13. doi:10.1038/s41467-022-32390-1
[Published Version]
View
| Files available
| DOI
| WoS
| PubMed | Europe PMC
2022 | Published | Journal Article | IST-REx-ID: 12117 |
Hübschmann V, Korkut M, Siegert S. Assessing human iPSC-derived microglia identity and function by immunostaining, phagocytosis, calcium activity, and inflammation assay. STAR Protocols. 2022;3(4). doi:10.1016/j.xpro.2022.101866
[Published Version]
View
| Files available
| DOI
2021 | Published | Journal Article | IST-REx-ID: 9642 |
Venturino A, Schulz R, De Jesús-Cortés H, et al. Microglia enable mature perineuronal nets disassembly upon anesthetic ketamine exposure or 60-Hz light entrainment in the healthy brain. Cell Reports. 2021;36(1). doi:10.1016/j.celrep.2021.109313
[Published Version]
View
| Files available
| DOI
| WoS
| PubMed | Europe PMC
2021 | Published | Journal Article | IST-REx-ID: 10565 |
Venturino A, Siegert S. Minimally invasive protocols and quantification for microglia-mediated perineuronal net disassembly in mouse brain. STAR Protocols. 2021;2(4). doi:10.1016/j.xpro.2021.101012
[Published Version]
View
| Files available
| DOI
2021 | Published | Journal Article | IST-REx-ID: 10655 |
Maes ME, Wögenstein GM, Colombo G, Casado Polanco R, Siegert S. Optimizing AAV2/6 microglial targeting identified enhanced efficiency in the photoreceptor degenerative environment. Molecular Therapy - Methods and Clinical Development. 2021;23:210-224. doi:10.1016/j.omtm.2021.09.006
[Published Version]
View
| Files available
| DOI
| WoS
2019 | Published | Journal Article | IST-REx-ID: 6521 |
Maes ME, Colombo G, Schulz R, Siegert S. Targeting microglia with lentivirus and AAV: Recent advances and remaining challenges. Neuroscience Letters. 2019;707. doi:10.1016/j.neulet.2019.134310
[Published Version]
View
| Files available
| DOI
| WoS
| PubMed | Europe PMC
2016 | Published | Journal Article | IST-REx-ID: 1253 |
Tsai L, Siegert S. How MicroRNAs Are involved in splitting the mind. JAMA Psychiatry. 2016;73(4):409-410. doi:10.1001/jamapsychiatry.2015.3144
[Submitted Version]
View
| Files available
| DOI
| PubMed | Europe PMC
2016 | Published | Journal Article | IST-REx-ID: 1613 |
Mungenast A, Siegert S, Tsai L. Modeling Alzheimer’s disease with human induced pluripotent stem (iPS) cells. Molecular and Cellular Neuroscience. 2016;73:13-31. doi:doi:10.1016/j.mcn.2015.11.010
[Submitted Version]
View
| Files available
| DOI
2015 | Published | Journal Article | IST-REx-ID: 1802
Siegert S, Seo J, Kwon E, et al. The schizophrenia risk gene product miR-137 alters presynaptic plasticity. Nature Neuroscience. 2015;18:1008-1016. doi:10.1038/nn.4023
View
| DOI
2015 | Published | Journal Article | IST-REx-ID: 1803
Rei D, Mason X, Seo J, et al. Basolateral amygdala bidirectionally modulates stress induced hippocampal learning and memory deficits through a p25/Cdk5-dependent pathway. PNAS. 2015;112(23):7291-7296. doi:10.1073/pnas.1415845112
View
| DOI
2012 | Published | Journal Article | IST-REx-ID: 1801
Siegert S, Cabuy E, Scherf B, et al. Transcriptional code and disease map for adult retinal cell types. Nature Neuroscience. 2012;15(3):487-495. doi:10.1038/nn.3032
View
| DOI
2010 | Published | Journal Article | IST-REx-ID: 1800
Busskamp V, Duebel J, Bálya D, et al. Genetic reactivation of cone photoreceptors restores visual responses in retinitis pigmentosa. Science. 2010;329(5990):413-417. doi:10.1126/science.1190897
View
| DOI
2009 | Published | Journal Article | IST-REx-ID: 1798
Siegert S, Scherf B, Del Punta K, Didkovsky N, Heintz N, Roska B. Genetic address book for retinal cell types. Nature Neuroscience. 2009;12(9):1197-1204. doi:10.1038/nn.2370
View
| DOI
2009 | Published | Journal Article | IST-REx-ID: 1799
Münch T, Da Silveira R, Siegert S, Viney T, Awatramani G, Roska B. Approach sensitivity in the retina processed by a multifunctional neural circuit. Nature Neuroscience. 2009;12(10):1308-1316. doi:10.1038/nn.2389
View
| DOI
2007 | Published | Journal Article | IST-REx-ID: 1797
Viney T, Bálint K, Hillier D, et al. Local retinal circuits of melanopsin-containing ganglion cells identified by transsynaptic viral tracing. Current Biology. 2007;17(11):981-988. doi:10.1016/j.cub.2007.04.058
View
| DOI
2006 | Published | Journal Article | IST-REx-ID: 1796
Siegert S, Schnierle P, Schnierle B. Novel anti-viral therapy: Drugs that block HIV entry at different target sites. Mini-Reviews in Medicinal Chemistry. 2006;6(5):557-562. doi:10.2174/138955706776876267
View
| DOI
2005 | Published | Journal Article | IST-REx-ID: 1795
Siegert S, Thaler S, Wagner R, Schnierle B. Assessment of HIV-1 entry inhibitors by MLV/HIV-1 pseudotyped vectors. AIDS Research and Therapy. 2005;2(1). doi:10.1186/1742-6405-2-7
View
| DOI