Harald L Janovjak

Janovjak Group

54 Publications

Mark all

[54]
2021 | Published | Journal Article | IST-REx-ID: 9363 | OA
Inglés Prieto Á, Furthmann N, Crossman SH, et al. Optogenetic delivery of trophic signals in a genetic model of Parkinson’s disease. PLoS genetics. 2021;17(4):e1009479. doi:10.1371/journal.pgen.1009479
[Published Version] View | Files available | DOI | WoS
 
[53]
2021 | Published | Journal Article | IST-REx-ID: 10144 | OA
Rauschendorfer T, Gurri S, Heggli I, et al. Acute and chronic effects of a light-activated FGF receptor in keratinocytes in vitro and in mice. Life Science Alliance. 2021;4(11). doi:10.26508/lsa.202101100
[Published Version] View | Files available | DOI | PubMed | Europe PMC
 
[52]
2020 | Published | Book Chapter | IST-REx-ID: 8173
Kainrath S, Janovjak HL. Design and application of light-regulated receptor tyrosine kinases. In: Niopek D, ed. Photoswitching Proteins. Vol 2173. MIMB. Springer Nature; 2020:233-246. doi:10.1007/978-1-0716-0755-8_16
View | DOI
 
[51]
2020 | Published | Journal Article | IST-REx-ID: 8674 | OA
Henneberger C, Bard L, Panatier A, Reynolds JP, Kopach O, Medvedev NI, Minge D, Herde MK, Anders S, Kraev I, Heller JP, Rama S, Zheng K, Jensen TP, Sanchez-Romero I, Jackson CJ, Janovjak HL, Ottersen OP, Nagelhus EA, Oliet SHR, Stewart MG, Nägerl UVa, Rusakov DA. 2020. LTP induction boosts glutamate spillover by driving withdrawal of perisynaptic astroglia. Neuron. 108(5), P919–936.E11.
[Published Version] View | Files available | DOI | WoS | PubMed | Europe PMC
 
[50]
2019 | Published | Journal Article | IST-REx-ID: 6025 | OA
Capek D, Smutny M, Tichy AM, Morri M, Janovjak HL, Heisenberg C-PJ. Light-activated Frizzled7 reveals a permissive role of non-canonical wnt signaling in mesendoderm cell migration. eLife. 2019;8. doi:10.7554/eLife.42093
[Published Version] View | Files available | DOI | WoS
 
[49]
2019 | Published | Journal Article | IST-REx-ID: 6564 | OA
Tichy A-M, Gerrard EJ, Legrand JMD, Hobbs RM, Janovjak HL. Engineering strategy and vector library for the rapid generation of modular light-controlled protein–protein interactions. Journal of Molecular Biology. 2019;431(17):3046-3055. doi:10.1016/j.jmb.2019.05.033
[Preprint] View | DOI | Download Preprint (ext.) | WoS
 
[48]
2019 | Published | Journal Article | IST-REx-ID: 7406
Mckenzie C, Spanova M, Johnson AJ, et al. Isolation of synaptic vesicles from genetically engineered cultured neurons. Journal of Neuroscience Methods. 2019;312:114-121. doi:10.1016/j.jneumeth.2018.11.018
View | DOI | WoS | PubMed | Europe PMC
 
[47]
2018 | Published | Journal Article | IST-REx-ID: 137 | OA
Zhang W, Herde M, Mitchell J, et al. Monitoring hippocampal glycine with the computationally designed optical sensor GlyFS. Nature Chemical Biology. 2018;14(9):861-869. doi:10.1038/s41589-018-0108-2
[Submitted Version] View | DOI | Download Submitted Version (ext.) | WoS | PubMed | Europe PMC
 
[46]
2018 | Published | Journal Article | IST-REx-ID: 5984 | OA
Morri M, Sanchez-Romero I, Tichy A-M, et al. Optical functionalization of human class A orphan G-protein-coupled receptors. Nature Communications. 2018;9(1). doi:10.1038/s41467-018-04342-1
[Published Version] View | Files available | DOI | WoS
 
[45]
2017 | Published | Journal Article | IST-REx-ID: 538 | OA
Kainrath S, Stadler M, Gschaider-Reichhart E, Distel M, Janovjak HL. Grünlicht-induzierte Rezeptorinaktivierung durch Cobalamin-bindende Domänen. Angewandte Chemie. 2017;129(16):4679-4682. doi:10.1002/ange.201611998
[Published Version] View | Files available | DOI
 
[44]
2017 | Published | Book Chapter | IST-REx-ID: 957
Clifton B, Whitfield J, Sanchez-Romero I, et al. Ancestral protein reconstruction and circular permutation for improving the stability and dynamic range of FRET sensors. In: Stein V, ed. Synthetic Protein Switches. Vol 1596. Synthetic Protein Switches. Springer; 2017:71-87. doi:10.1007/978-1-4939-6940-1_5
View | DOI
 
[43]
2017 | Published | Book Chapter | IST-REx-ID: 958
Mitchell J, Zhang W, Herde M, et al. Method for developing optical sensors using a synthetic dye fluorescent protein FRET pair and computational modeling and assessment. In: Stein V, ed. Synthetic Protein Switches. Vol 1596. Synthetic Protein Switches. Springer; 2017:89-99. doi:10.1007/978-1-4939-6940-1_6
View | DOI
 
[42]
2017 | Published | Journal Article | IST-REx-ID: 1026
Agus V, Janovjak HL. Optogenetic methods in drug screening: Technologies and applications. Current Opinion in Biotechnology. 2017;48:8-14. doi:10.1016/j.copbio.2017.02.006
View | DOI | WoS
 
[41]
2017 | Published | Journal Article | IST-REx-ID: 1028 | OA
Kainrath S, Stadler M, Gschaider-Reichhart E, Distel M, Janovjak HL. Green-light-induced inactivation of receptor signaling using cobalamin-binding domains. Angewandte Chemie - International Edition. 2017;56(16):4608-4611. doi:10.1002/anie.201611998
[Published Version] View | Files available | DOI | WoS
 
[40]
2016 | Published | Journal Article | IST-REx-ID: 1100 | OA
Sako K, Pradhan S, Barone V, et al. Optogenetic control of nodal signaling reveals a temporal pattern of nodal signaling regulating cell fate specification during gastrulation. Cell Reports. 2016;16(3):866-877. doi:10.1016/j.celrep.2016.06.036
[Published Version] View | Files available | DOI
 
[39]
2016 | Published | Journal Article | IST-REx-ID: 1101
Mitchell J, Whitfield J, Zhang W, et al. Rangefinder: A semisynthetic FRET sensor design algorithm. ACS SENSORS. 2016;1(11):1286-1290. doi:10.1021/acssensors.6b00576
View | DOI
 
[38]
2016 | Published | Journal Article | IST-REx-ID: 1440
Janovjak HL. Light at the end of the protein: Crystal structure of a C-terminal light-sensing domain. Structure. 2016;24(2):213-215. doi:10.1016/j.str.2016.01.002
View | DOI
 
[37]
2016 | Published | Journal Article | IST-REx-ID: 1441 | OA
Gschaider-Reichhart E, Inglés Prieto Á, Tichy A-M, Mckenzie C, Janovjak HL. A phytochrome sensory domain permits receptor activation by red light. Angewandte Chemie - International Edition. 2016;55(21):6339-6342. doi:10.1002/anie.201601736
[Submitted Version] View | Files available | DOI
 
[36]
2015 | Published | Book Chapter | IST-REx-ID: 1549 | OA
Mckenzie C, Sanchez-Romero I, Janovjak HL. Flipping the photoswitch: Ion channels under light control. In: Novel Chemical Tools to Study Ion Channel Biology. Vol 869. Advances in Experimental Medicine and Biology. Springer; 2015:101-117. doi:10.1007/978-1-4939-2845-3_6
[Submitted Version] View | Files available | DOI
 
[35]
2015 | Published | Journal Article | IST-REx-ID: 1611 | OA
Whitfield J, Zhang W, Herde M, et al. Construction of a robust and sensitive arginine biosensor through ancestral protein reconstruction. Protein Science. 2015;24(9):1412-1422. doi:10.1002/pro.2721
[Submitted Version] View | DOI | Download Submitted Version (ext.) | PubMed | Europe PMC
 
[34]
2015 | Published | Journal Article | IST-REx-ID: 1678 | OA
Inglés Prieto Á, Gschaider-Reichhart E, Muellner M, et al. Light-assisted small-molecule screening against protein kinases. Nature Chemical Biology. 2015;11(12):952-954. doi:10.1038/nchembio.1933
[Submitted Version] View | Files available | DOI
 
[33]
2015 | Published | Journal Article | IST-REx-ID: 1867
Hühner J, Inglés Prieto Á, Neusüß C, Lämmerhofer M, Janovjak HL. Quantification of riboflavin, flavin mononucleotide, and flavin adenine dinucleotide in mammalian model cells by CE with LED-induced fluorescence detection. Electrophoresis. 2015;36(4):518-525. doi:10.1002/elps.201400451
View | DOI
 
[32]
2014 | Published | Journal Article | IST-REx-ID: 2032 | OA
Inglés Prieto Á, Gschaider-Reichhart E, Schelch K, Janovjak HL, Grusch M. The optogenetic promise for oncology: Episode I. Molecular and Cellular Oncology. 2014;1(4). doi:10.4161/23723548.2014.964045
[Published Version] View | Files available | DOI
 
[31]
2014 | Published | Journal Article | IST-REx-ID: 2084 | OA
Grusch M, Schelch K, Riedler R, et al. Spatio-temporally precise activation of engineered receptor tyrosine kinases by light. EMBO Journal. 2014;33(15):1713-1726. doi:10.15252/embj.201387695
[Submitted Version] View | Files available | DOI | Download Submitted Version (ext.)
 
[30]
2013 | Published | Journal Article | IST-REx-ID: 2856 | OA
Levitz J, Pantoja C, Gaub B, et al. Optical control of metabotropic glutamate receptors. Nature Neuroscience. 2013;16:507-516. doi:10.1038/nn.3346
[Submitted Version] View | DOI | Download Submitted Version (ext.) | PubMed | Europe PMC
 
[29]
2013 | Published | Journal Article | IST-REx-ID: 2857 | OA
Szobota S, Mckenzie C, Janovjak HL. Optical control of ligand-gated ion channels. Methods in Molecular Biology. 2013;998:417-435. doi:10.1007/978-1-62703-351-0_32
[Submitted Version] View | Files available | DOI
 
[28]
2011 | Published | Journal Article | IST-REx-ID: 3405 | OA
Janovjak HL, Sandoz G, Isacoff E. Modern ionotropic glutamate receptor with a K+ selectivity signature sequence. Nature Communications. 2011;2(232):1-6. doi:10.1038/ncomms1231
[Submitted Version] View | Files available | DOI
 
[27]
2011 | Published | Book Chapter | IST-REx-ID: 3724
Janovjak HL, Isacoff E. Structure-based design of light-controlled proteins. In: Photosensitive Molecules for the Control of Biological Function. Vol 55. Springer; 2011:233-266. doi:10.1007/978-1-61779-031-7_13
View | DOI
 
[26]
2010 | Published | Book Review | IST-REx-ID: 3406
Stawski P, Janovjak HL, Trauner D. Pharmacology of ionotropic glutamate receptors: a structural perspective. Bioorganic and Medicinal Chemistry. 2010;18(22):7759-7772. doi:10.1016/j.bmc.2010.09.012
View | DOI
 
[25]
2010 | Published | Journal Article | IST-REx-ID: 3407
Janovjak HL, Szobota S, Wyart C, Trauner D, Isacoff E. A light-gated, potassium-selective glutamate receptor for the optical inhibition of neuronal firing. Nature Neuroscience. 2010;13:1027-1032. doi:10.1038/nn.2589
View | DOI
 
[24]
2009 | Published | Journal Article | IST-REx-ID: 3408
Szymczak P, Janovjak HL. Periodic forces trigger a complex mechanical response in ubiquitin. Journal of Molecular Biology. 2009;390(3):443-456. doi:10.1016/j.jmb.2009.04.071
View | DOI
 
[23]
2008 | Published | Journal Article | IST-REx-ID: 3409
Struckmeier J, Wahl R, Leuschner M, et al. Fully automated single-molecule force spectroscopy for screening applications. Nanotechnology. 2008;19(38). doi:10.1088/0957-4484/19/38/384020
View | DOI
 
[22]
2008 | Published | Book Review | IST-REx-ID: 3410
Janovjak HL, Sapra T, Kedrov A, Mueller D. From valleys to ridges: Exploring the energy landscape of single membrane proteins. ChemPhysChem. 2008;9(7):954-966. doi:10.1002/cphc.200700662
View | DOI
 
[21]
2008 | Published | Book Chapter | IST-REx-ID: 3726
Engel A, Janovjak HL, Fotiadis D, Kedrov A, Cisneros D, Mueller D. Single-molecule microscopy and force spectroscopy of membrane proteins. In: Single Molecules and Nanotechnology. Vol 12. Springer; 2008:279-311. doi:10.1007/978-3-540-73924-1_11
View | DOI
 
[20]
2007 | Published | Journal Article | IST-REx-ID: 3411 | OA
Preiner J, Janovjak HL, Rankl C, et al. Free energy of membrane protein unfolding derived from single-molecule force measurements. Biophysical Journal. 2007;93(3):930-937. doi:10.1529/biophysj.106.096982
View | DOI | Download (ext.)
 
[19]
2007 | Published | Book Review | IST-REx-ID: 3412
Kedrov A, Janovjak HL, Sapra T, Mueller D. Deciphering molecular interactions of native membrane proteins by single-molecule force spectroscopy. Annual Review of Biophysics. 2007;36:233-260. doi:10.1146/annurev.biophys.36.040306.132640
View | DOI
 
[18]
2007 | Published | Journal Article | IST-REx-ID: 3723
Janovjak HL, Knaus H, Mueller D. Transmembrane helices have rough energy surfaces. Journal of the American Chemical Society. 2007;129(2):246-247. doi:10.1021/ja065684a
View | DOI
 
[17]
2007 | Published | Journal Article | IST-REx-ID: 3727
Bippes C, Janovjak HL, Kedrov A, Mueller D. Digital force-feedback for protein unfolding experiments using atomic force microscopy. Nanotechnology. 2007;18(4). doi:10.1088/0957-4484/18/4/044022
View | DOI
 
[16]
2006 | Published | Book Chapter | IST-REx-ID: 3404
Janovjak HL, Sawhney R, Stark M, Mueller D. Atomic force microscopy. In: Techniques in Microscopy for Biomedical Applications. Vol 2. World Scientific Publishing; 2006:213-284.
View
 
[15]
2006 | Published | Journal Article | IST-REx-ID: 3413
Kessler M, Gottschalk K, Janovjak HL, Mueller D, Gaub H. Bacteriorhodopsin folds into the membrane against an external force. Journal of Molecular Biology. 2006;357(2):644-654. doi:10.1016/j.jmb.2005.12.065
View | DOI
 
[14]
2006 | Published | Journal Article | IST-REx-ID: 3414
Kedrov A, Janovjak HL, Ziegler C, Kühlbrandt W, Mueller D. Observing folding pathways and kinetics of a single sodium-proton antiporter from Escherichia coli. Journal of Molecular Biology. 2006;355(1):2-8. doi:10.1016/j.jmb.2005.10.028
View | DOI
 
[13]
2006 | Published | Book Review | IST-REx-ID: 3415
Janovjak HL, Kedrov A, Cisneros D, Sapra T, Struckmeier J, Mueller D. Imaging and detecting molecular interactions of single membrane proteins. Neurobiology of Aging. 2006;27:546-561. doi:10.1016/j.neurobiolaging.2005.03.031
View | DOI
 
[12]
2006 | Published | Book Chapter | IST-REx-ID: 3722
Janovjak HL, Mueller D. Rastersondenmikroskopie. In: Bioanalytik. Spektrum Akademischer Verlag; 2006.
View
 
[11]
2006 | Published | Journal Article | IST-REx-ID: 3728
Cieplak M, Filipek S, Janovjak HL, Krzysko K. Pulling single bacteriorhodopsin out of a membrane: Comparison of simulation and experiment. Biochimica et Biophysica Acta (BBA) - Biomembranes. 2006;1758(4):537-544. doi:10.1016/j.bbamem.2006.03.028
View | DOI
 
[10]
2006 | Published | Journal Article | IST-REx-ID: 3729
Bippes C, Humphris A, Stark M, Mueller D, Janovjak HL. Direct measurement of single-molecule visco-elasticity in atomic force microscope force-extension experiments. European Biophysics Journal. 2006;35(3):287-292. doi:10.1007/s00249-005-0023-9
View | DOI
 
[9]
2005 | Published | Journal Article | IST-REx-ID: 3416 | OA
Janovjak HL, Sapra T, Mueller D. Complex stability of single proteins explored by forced unfolding experiments. Biophysical Journal. 2005;88(5):37-39. doi:10.1529/biophysj.105.059774
View | DOI | Download (ext.)
 
[8]
2005 | Published | Journal Article | IST-REx-ID: 3417
Kuhn M, Janovjak HL, Hubain M, Mueller D. Automated alignment and pattern recognition of single-molecule force spectroscopy data. Journal of Microscopy. 2005;218(2):125-132. doi:10.1111/j.1365-2818.2005.01478.x
View | DOI
 
[7]
2005 | Published | Journal Article | IST-REx-ID: 3418
Janovjak HL, Struckmeier J, Mueller D. Hydrodynamic effects in fast AFM single molecule force measurements. European Biophysics Journal. 2005;34(1):91-96. doi:10.1007/s00249-004-0430-3
View | DOI
 
[6]
2005 | Published | Journal Article | IST-REx-ID: 3721 | OA
Janovjak HL, Mueller D, Humphris A. Molecular force modulation spectroscopy revealing the dynamic response of single bacteriorhodopsins. Biophysical Journal. 2005;88(2):1423-1431. doi:10.1529/biophysj.104.052746
View | DOI | Download (ext.)
 
[5]
2004 | Published | Journal Article | IST-REx-ID: 3419
Janovjak HL, Struckmeier J, Hubain M, Kessler M, Kedrov A, Mueller D. Probing the energy landscape of the membrane protein bacteriorhodopsin. Structure. 2004;12(5):871-879. doi:10.1016/j.str.2004.03.016
View | DOI
 
[4]
2004 | Published | Journal Article | IST-REx-ID: 3420
Kedrov A, Ziegler C, Janovjak HL, Kühlbrandt W, Mueller D. Controlled unfolding and refolding of a single sodium/proton antiporter using atomic force microscopy. Journal of Molecular Biology. 2004;340(5):1143-1152. doi:10.1016/j.jmb.2004.05.026
View | DOI
 
[3]
2003 | Published | Journal Article | IST-REx-ID: 3725 | OA
Janovjak HL, Kessler M, Oesterhelt D, Gaub H, Mueller D. Unfolding pathways of native bacteriorhodopsin depend on temperature. EMBO Journal. 2003;22(19):5220-5229. doi:10.1093/emboj/cdg509
View | DOI | Download (ext.)
 
[2]
2002 | Published | Journal Article | IST-REx-ID: 3421
Mueller D, Janovjak HL, Lehto T, Kuerschner L, Anderson K. Observing structure, function and assembly of single proteins by AFM. Progress in Biophysics and Molecular Biology. 2002;79(1-3):1-43. doi:10.1016/S0079-6107(02)00009-3
View | DOI | PubMed | Europe PMC
 
[1]
2002 | Published | Journal Article | IST-REx-ID: 3422
Müller P, Janovjak HL, Miserez A, Dobbie Z. Processing of gene expression data generated by quantitative real-time RT-PCR. Biotechniques. 2002;32(6):1372-1379.
View | PubMed | Europe PMC
 
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54 Publications

Mark all

[54]
2021 | Published | Journal Article | IST-REx-ID: 9363 | OA
Inglés Prieto Á, Furthmann N, Crossman SH, et al. Optogenetic delivery of trophic signals in a genetic model of Parkinson’s disease. PLoS genetics. 2021;17(4):e1009479. doi:10.1371/journal.pgen.1009479
[Published Version] View | Files available | DOI | WoS
 
[53]
2021 | Published | Journal Article | IST-REx-ID: 10144 | OA
Rauschendorfer T, Gurri S, Heggli I, et al. Acute and chronic effects of a light-activated FGF receptor in keratinocytes in vitro and in mice. Life Science Alliance. 2021;4(11). doi:10.26508/lsa.202101100
[Published Version] View | Files available | DOI | PubMed | Europe PMC
 
[52]
2020 | Published | Book Chapter | IST-REx-ID: 8173
Kainrath S, Janovjak HL. Design and application of light-regulated receptor tyrosine kinases. In: Niopek D, ed. Photoswitching Proteins. Vol 2173. MIMB. Springer Nature; 2020:233-246. doi:10.1007/978-1-0716-0755-8_16
View | DOI
 
[51]
2020 | Published | Journal Article | IST-REx-ID: 8674 | OA
Henneberger C, Bard L, Panatier A, Reynolds JP, Kopach O, Medvedev NI, Minge D, Herde MK, Anders S, Kraev I, Heller JP, Rama S, Zheng K, Jensen TP, Sanchez-Romero I, Jackson CJ, Janovjak HL, Ottersen OP, Nagelhus EA, Oliet SHR, Stewart MG, Nägerl UVa, Rusakov DA. 2020. LTP induction boosts glutamate spillover by driving withdrawal of perisynaptic astroglia. Neuron. 108(5), P919–936.E11.
[Published Version] View | Files available | DOI | WoS | PubMed | Europe PMC
 
[50]
2019 | Published | Journal Article | IST-REx-ID: 6025 | OA
Capek D, Smutny M, Tichy AM, Morri M, Janovjak HL, Heisenberg C-PJ. Light-activated Frizzled7 reveals a permissive role of non-canonical wnt signaling in mesendoderm cell migration. eLife. 2019;8. doi:10.7554/eLife.42093
[Published Version] View | Files available | DOI | WoS
 
[49]
2019 | Published | Journal Article | IST-REx-ID: 6564 | OA
Tichy A-M, Gerrard EJ, Legrand JMD, Hobbs RM, Janovjak HL. Engineering strategy and vector library for the rapid generation of modular light-controlled protein–protein interactions. Journal of Molecular Biology. 2019;431(17):3046-3055. doi:10.1016/j.jmb.2019.05.033
[Preprint] View | DOI | Download Preprint (ext.) | WoS
 
[48]
2019 | Published | Journal Article | IST-REx-ID: 7406
Mckenzie C, Spanova M, Johnson AJ, et al. Isolation of synaptic vesicles from genetically engineered cultured neurons. Journal of Neuroscience Methods. 2019;312:114-121. doi:10.1016/j.jneumeth.2018.11.018
View | DOI | WoS | PubMed | Europe PMC
 
[47]
2018 | Published | Journal Article | IST-REx-ID: 137 | OA
Zhang W, Herde M, Mitchell J, et al. Monitoring hippocampal glycine with the computationally designed optical sensor GlyFS. Nature Chemical Biology. 2018;14(9):861-869. doi:10.1038/s41589-018-0108-2
[Submitted Version] View | DOI | Download Submitted Version (ext.) | WoS | PubMed | Europe PMC
 
[46]
2018 | Published | Journal Article | IST-REx-ID: 5984 | OA
Morri M, Sanchez-Romero I, Tichy A-M, et al. Optical functionalization of human class A orphan G-protein-coupled receptors. Nature Communications. 2018;9(1). doi:10.1038/s41467-018-04342-1
[Published Version] View | Files available | DOI | WoS
 
[45]
2017 | Published | Journal Article | IST-REx-ID: 538 | OA
Kainrath S, Stadler M, Gschaider-Reichhart E, Distel M, Janovjak HL. Grünlicht-induzierte Rezeptorinaktivierung durch Cobalamin-bindende Domänen. Angewandte Chemie. 2017;129(16):4679-4682. doi:10.1002/ange.201611998
[Published Version] View | Files available | DOI
 
[44]
2017 | Published | Book Chapter | IST-REx-ID: 957
Clifton B, Whitfield J, Sanchez-Romero I, et al. Ancestral protein reconstruction and circular permutation for improving the stability and dynamic range of FRET sensors. In: Stein V, ed. Synthetic Protein Switches. Vol 1596. Synthetic Protein Switches. Springer; 2017:71-87. doi:10.1007/978-1-4939-6940-1_5
View | DOI
 
[43]
2017 | Published | Book Chapter | IST-REx-ID: 958
Mitchell J, Zhang W, Herde M, et al. Method for developing optical sensors using a synthetic dye fluorescent protein FRET pair and computational modeling and assessment. In: Stein V, ed. Synthetic Protein Switches. Vol 1596. Synthetic Protein Switches. Springer; 2017:89-99. doi:10.1007/978-1-4939-6940-1_6
View | DOI
 
[42]
2017 | Published | Journal Article | IST-REx-ID: 1026
Agus V, Janovjak HL. Optogenetic methods in drug screening: Technologies and applications. Current Opinion in Biotechnology. 2017;48:8-14. doi:10.1016/j.copbio.2017.02.006
View | DOI | WoS
 
[41]
2017 | Published | Journal Article | IST-REx-ID: 1028 | OA
Kainrath S, Stadler M, Gschaider-Reichhart E, Distel M, Janovjak HL. Green-light-induced inactivation of receptor signaling using cobalamin-binding domains. Angewandte Chemie - International Edition. 2017;56(16):4608-4611. doi:10.1002/anie.201611998
[Published Version] View | Files available | DOI | WoS
 
[40]
2016 | Published | Journal Article | IST-REx-ID: 1100 | OA
Sako K, Pradhan S, Barone V, et al. Optogenetic control of nodal signaling reveals a temporal pattern of nodal signaling regulating cell fate specification during gastrulation. Cell Reports. 2016;16(3):866-877. doi:10.1016/j.celrep.2016.06.036
[Published Version] View | Files available | DOI
 
[39]
2016 | Published | Journal Article | IST-REx-ID: 1101
Mitchell J, Whitfield J, Zhang W, et al. Rangefinder: A semisynthetic FRET sensor design algorithm. ACS SENSORS. 2016;1(11):1286-1290. doi:10.1021/acssensors.6b00576
View | DOI
 
[38]
2016 | Published | Journal Article | IST-REx-ID: 1440
Janovjak HL. Light at the end of the protein: Crystal structure of a C-terminal light-sensing domain. Structure. 2016;24(2):213-215. doi:10.1016/j.str.2016.01.002
View | DOI
 
[37]
2016 | Published | Journal Article | IST-REx-ID: 1441 | OA
Gschaider-Reichhart E, Inglés Prieto Á, Tichy A-M, Mckenzie C, Janovjak HL. A phytochrome sensory domain permits receptor activation by red light. Angewandte Chemie - International Edition. 2016;55(21):6339-6342. doi:10.1002/anie.201601736
[Submitted Version] View | Files available | DOI
 
[36]
2015 | Published | Book Chapter | IST-REx-ID: 1549 | OA
Mckenzie C, Sanchez-Romero I, Janovjak HL. Flipping the photoswitch: Ion channels under light control. In: Novel Chemical Tools to Study Ion Channel Biology. Vol 869. Advances in Experimental Medicine and Biology. Springer; 2015:101-117. doi:10.1007/978-1-4939-2845-3_6
[Submitted Version] View | Files available | DOI
 
[35]
2015 | Published | Journal Article | IST-REx-ID: 1611 | OA
Whitfield J, Zhang W, Herde M, et al. Construction of a robust and sensitive arginine biosensor through ancestral protein reconstruction. Protein Science. 2015;24(9):1412-1422. doi:10.1002/pro.2721
[Submitted Version] View | DOI | Download Submitted Version (ext.) | PubMed | Europe PMC
 
[34]
2015 | Published | Journal Article | IST-REx-ID: 1678 | OA
Inglés Prieto Á, Gschaider-Reichhart E, Muellner M, et al. Light-assisted small-molecule screening against protein kinases. Nature Chemical Biology. 2015;11(12):952-954. doi:10.1038/nchembio.1933
[Submitted Version] View | Files available | DOI
 
[33]
2015 | Published | Journal Article | IST-REx-ID: 1867
Hühner J, Inglés Prieto Á, Neusüß C, Lämmerhofer M, Janovjak HL. Quantification of riboflavin, flavin mononucleotide, and flavin adenine dinucleotide in mammalian model cells by CE with LED-induced fluorescence detection. Electrophoresis. 2015;36(4):518-525. doi:10.1002/elps.201400451
View | DOI
 
[32]
2014 | Published | Journal Article | IST-REx-ID: 2032 | OA
Inglés Prieto Á, Gschaider-Reichhart E, Schelch K, Janovjak HL, Grusch M. The optogenetic promise for oncology: Episode I. Molecular and Cellular Oncology. 2014;1(4). doi:10.4161/23723548.2014.964045
[Published Version] View | Files available | DOI
 
[31]
2014 | Published | Journal Article | IST-REx-ID: 2084 | OA
Grusch M, Schelch K, Riedler R, et al. Spatio-temporally precise activation of engineered receptor tyrosine kinases by light. EMBO Journal. 2014;33(15):1713-1726. doi:10.15252/embj.201387695
[Submitted Version] View | Files available | DOI | Download Submitted Version (ext.)
 
[30]
2013 | Published | Journal Article | IST-REx-ID: 2856 | OA
Levitz J, Pantoja C, Gaub B, et al. Optical control of metabotropic glutamate receptors. Nature Neuroscience. 2013;16:507-516. doi:10.1038/nn.3346
[Submitted Version] View | DOI | Download Submitted Version (ext.) | PubMed | Europe PMC
 
[29]
2013 | Published | Journal Article | IST-REx-ID: 2857 | OA
Szobota S, Mckenzie C, Janovjak HL. Optical control of ligand-gated ion channels. Methods in Molecular Biology. 2013;998:417-435. doi:10.1007/978-1-62703-351-0_32
[Submitted Version] View | Files available | DOI
 
[28]
2011 | Published | Journal Article | IST-REx-ID: 3405 | OA
Janovjak HL, Sandoz G, Isacoff E. Modern ionotropic glutamate receptor with a K+ selectivity signature sequence. Nature Communications. 2011;2(232):1-6. doi:10.1038/ncomms1231
[Submitted Version] View | Files available | DOI
 
[27]
2011 | Published | Book Chapter | IST-REx-ID: 3724
Janovjak HL, Isacoff E. Structure-based design of light-controlled proteins. In: Photosensitive Molecules for the Control of Biological Function. Vol 55. Springer; 2011:233-266. doi:10.1007/978-1-61779-031-7_13
View | DOI
 
[26]
2010 | Published | Book Review | IST-REx-ID: 3406
Stawski P, Janovjak HL, Trauner D. Pharmacology of ionotropic glutamate receptors: a structural perspective. Bioorganic and Medicinal Chemistry. 2010;18(22):7759-7772. doi:10.1016/j.bmc.2010.09.012
View | DOI
 
[25]
2010 | Published | Journal Article | IST-REx-ID: 3407
Janovjak HL, Szobota S, Wyart C, Trauner D, Isacoff E. A light-gated, potassium-selective glutamate receptor for the optical inhibition of neuronal firing. Nature Neuroscience. 2010;13:1027-1032. doi:10.1038/nn.2589
View | DOI
 
[24]
2009 | Published | Journal Article | IST-REx-ID: 3408
Szymczak P, Janovjak HL. Periodic forces trigger a complex mechanical response in ubiquitin. Journal of Molecular Biology. 2009;390(3):443-456. doi:10.1016/j.jmb.2009.04.071
View | DOI
 
[23]
2008 | Published | Journal Article | IST-REx-ID: 3409
Struckmeier J, Wahl R, Leuschner M, et al. Fully automated single-molecule force spectroscopy for screening applications. Nanotechnology. 2008;19(38). doi:10.1088/0957-4484/19/38/384020
View | DOI
 
[22]
2008 | Published | Book Review | IST-REx-ID: 3410
Janovjak HL, Sapra T, Kedrov A, Mueller D. From valleys to ridges: Exploring the energy landscape of single membrane proteins. ChemPhysChem. 2008;9(7):954-966. doi:10.1002/cphc.200700662
View | DOI
 
[21]
2008 | Published | Book Chapter | IST-REx-ID: 3726
Engel A, Janovjak HL, Fotiadis D, Kedrov A, Cisneros D, Mueller D. Single-molecule microscopy and force spectroscopy of membrane proteins. In: Single Molecules and Nanotechnology. Vol 12. Springer; 2008:279-311. doi:10.1007/978-3-540-73924-1_11
View | DOI
 
[20]
2007 | Published | Journal Article | IST-REx-ID: 3411 | OA
Preiner J, Janovjak HL, Rankl C, et al. Free energy of membrane protein unfolding derived from single-molecule force measurements. Biophysical Journal. 2007;93(3):930-937. doi:10.1529/biophysj.106.096982
View | DOI | Download (ext.)
 
[19]
2007 | Published | Book Review | IST-REx-ID: 3412
Kedrov A, Janovjak HL, Sapra T, Mueller D. Deciphering molecular interactions of native membrane proteins by single-molecule force spectroscopy. Annual Review of Biophysics. 2007;36:233-260. doi:10.1146/annurev.biophys.36.040306.132640
View | DOI
 
[18]
2007 | Published | Journal Article | IST-REx-ID: 3723
Janovjak HL, Knaus H, Mueller D. Transmembrane helices have rough energy surfaces. Journal of the American Chemical Society. 2007;129(2):246-247. doi:10.1021/ja065684a
View | DOI
 
[17]
2007 | Published | Journal Article | IST-REx-ID: 3727
Bippes C, Janovjak HL, Kedrov A, Mueller D. Digital force-feedback for protein unfolding experiments using atomic force microscopy. Nanotechnology. 2007;18(4). doi:10.1088/0957-4484/18/4/044022
View | DOI
 
[16]
2006 | Published | Book Chapter | IST-REx-ID: 3404
Janovjak HL, Sawhney R, Stark M, Mueller D. Atomic force microscopy. In: Techniques in Microscopy for Biomedical Applications. Vol 2. World Scientific Publishing; 2006:213-284.
View
 
[15]
2006 | Published | Journal Article | IST-REx-ID: 3413
Kessler M, Gottschalk K, Janovjak HL, Mueller D, Gaub H. Bacteriorhodopsin folds into the membrane against an external force. Journal of Molecular Biology. 2006;357(2):644-654. doi:10.1016/j.jmb.2005.12.065
View | DOI
 
[14]
2006 | Published | Journal Article | IST-REx-ID: 3414
Kedrov A, Janovjak HL, Ziegler C, Kühlbrandt W, Mueller D. Observing folding pathways and kinetics of a single sodium-proton antiporter from Escherichia coli. Journal of Molecular Biology. 2006;355(1):2-8. doi:10.1016/j.jmb.2005.10.028
View | DOI
 
[13]
2006 | Published | Book Review | IST-REx-ID: 3415
Janovjak HL, Kedrov A, Cisneros D, Sapra T, Struckmeier J, Mueller D. Imaging and detecting molecular interactions of single membrane proteins. Neurobiology of Aging. 2006;27:546-561. doi:10.1016/j.neurobiolaging.2005.03.031
View | DOI
 
[12]
2006 | Published | Book Chapter | IST-REx-ID: 3722
Janovjak HL, Mueller D. Rastersondenmikroskopie. In: Bioanalytik. Spektrum Akademischer Verlag; 2006.
View
 
[11]
2006 | Published | Journal Article | IST-REx-ID: 3728
Cieplak M, Filipek S, Janovjak HL, Krzysko K. Pulling single bacteriorhodopsin out of a membrane: Comparison of simulation and experiment. Biochimica et Biophysica Acta (BBA) - Biomembranes. 2006;1758(4):537-544. doi:10.1016/j.bbamem.2006.03.028
View | DOI
 
[10]
2006 | Published | Journal Article | IST-REx-ID: 3729
Bippes C, Humphris A, Stark M, Mueller D, Janovjak HL. Direct measurement of single-molecule visco-elasticity in atomic force microscope force-extension experiments. European Biophysics Journal. 2006;35(3):287-292. doi:10.1007/s00249-005-0023-9
View | DOI
 
[9]
2005 | Published | Journal Article | IST-REx-ID: 3416 | OA
Janovjak HL, Sapra T, Mueller D. Complex stability of single proteins explored by forced unfolding experiments. Biophysical Journal. 2005;88(5):37-39. doi:10.1529/biophysj.105.059774
View | DOI | Download (ext.)
 
[8]
2005 | Published | Journal Article | IST-REx-ID: 3417
Kuhn M, Janovjak HL, Hubain M, Mueller D. Automated alignment and pattern recognition of single-molecule force spectroscopy data. Journal of Microscopy. 2005;218(2):125-132. doi:10.1111/j.1365-2818.2005.01478.x
View | DOI
 
[7]
2005 | Published | Journal Article | IST-REx-ID: 3418
Janovjak HL, Struckmeier J, Mueller D. Hydrodynamic effects in fast AFM single molecule force measurements. European Biophysics Journal. 2005;34(1):91-96. doi:10.1007/s00249-004-0430-3
View | DOI
 
[6]
2005 | Published | Journal Article | IST-REx-ID: 3721 | OA
Janovjak HL, Mueller D, Humphris A. Molecular force modulation spectroscopy revealing the dynamic response of single bacteriorhodopsins. Biophysical Journal. 2005;88(2):1423-1431. doi:10.1529/biophysj.104.052746
View | DOI | Download (ext.)
 
[5]
2004 | Published | Journal Article | IST-REx-ID: 3419
Janovjak HL, Struckmeier J, Hubain M, Kessler M, Kedrov A, Mueller D. Probing the energy landscape of the membrane protein bacteriorhodopsin. Structure. 2004;12(5):871-879. doi:10.1016/j.str.2004.03.016
View | DOI
 
[4]
2004 | Published | Journal Article | IST-REx-ID: 3420
Kedrov A, Ziegler C, Janovjak HL, Kühlbrandt W, Mueller D. Controlled unfolding and refolding of a single sodium/proton antiporter using atomic force microscopy. Journal of Molecular Biology. 2004;340(5):1143-1152. doi:10.1016/j.jmb.2004.05.026
View | DOI
 
[3]
2003 | Published | Journal Article | IST-REx-ID: 3725 | OA
Janovjak HL, Kessler M, Oesterhelt D, Gaub H, Mueller D. Unfolding pathways of native bacteriorhodopsin depend on temperature. EMBO Journal. 2003;22(19):5220-5229. doi:10.1093/emboj/cdg509
View | DOI | Download (ext.)
 
[2]
2002 | Published | Journal Article | IST-REx-ID: 3421
Mueller D, Janovjak HL, Lehto T, Kuerschner L, Anderson K. Observing structure, function and assembly of single proteins by AFM. Progress in Biophysics and Molecular Biology. 2002;79(1-3):1-43. doi:10.1016/S0079-6107(02)00009-3
View | DOI | PubMed | Europe PMC
 
[1]
2002 | Published | Journal Article | IST-REx-ID: 3422
Müller P, Janovjak HL, Miserez A, Dobbie Z. Processing of gene expression data generated by quantitative real-time RT-PCR. Biotechniques. 2002;32(6):1372-1379.
View | PubMed | Europe PMC
 
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