{"page":"916-919","doi":"10.1126/science.1186366","publication":"Science","author":[{"last_name":"Zemach","first_name":"Assaf ","full_name":"Zemach, Assaf "},{"full_name":"McDaniel, Ivy E.","last_name":"McDaniel","first_name":"Ivy E."},{"last_name":"Silva","first_name":"Pedro","full_name":"Silva, Pedro"},{"orcid":"0000-0002-0123-8649","first_name":"Daniel","last_name":"Zilberman","full_name":"Zilberman, Daniel","id":"6973db13-dd5f-11ea-814e-b3e5455e9ed1"}],"external_id":{"pmid":["20395474 "]},"publication_identifier":{"issn":["0036-8075"],"eissn":["1095-9203"]},"citation":{"ama":"Zemach A, McDaniel IE, Silva P, Zilberman D. Genome-wide evolutionary analysis of eukaryotic DNA methylation. <i>Science</i>. 2010;328(5980):916-919. doi:<a href=\"https://doi.org/10.1126/science.1186366\">10.1126/science.1186366</a>","chicago":"Zemach, Assaf , Ivy E. McDaniel, Pedro Silva, and Daniel Zilberman. “Genome-Wide Evolutionary Analysis of Eukaryotic DNA Methylation.” <i>Science</i>. American Association for the Advancement of Science, 2010. <a href=\"https://doi.org/10.1126/science.1186366\">https://doi.org/10.1126/science.1186366</a>.","ista":"Zemach A, McDaniel IE, Silva P, Zilberman D. 2010. Genome-wide evolutionary analysis of eukaryotic DNA methylation. Science. 328(5980), 916–919.","apa":"Zemach, A., McDaniel, I. E., Silva, P., &#38; Zilberman, D. (2010). Genome-wide evolutionary analysis of eukaryotic DNA methylation. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.1186366\">https://doi.org/10.1126/science.1186366</a>","short":"A. Zemach, I.E. McDaniel, P. Silva, D. Zilberman, Science 328 (2010) 916–919.","mla":"Zemach, Assaf, et al. “Genome-Wide Evolutionary Analysis of Eukaryotic DNA Methylation.” <i>Science</i>, vol. 328, no. 5980, American Association for the Advancement of Science, 2010, pp. 916–19, doi:<a href=\"https://doi.org/10.1126/science.1186366\">10.1126/science.1186366</a>.","ieee":"A. Zemach, I. E. McDaniel, P. Silva, and D. Zilberman, “Genome-wide evolutionary analysis of eukaryotic DNA methylation,” <i>Science</i>, vol. 328, no. 5980. American Association for the Advancement of Science, pp. 916–919, 2010."},"article_type":"original","language":[{"iso":"eng"}],"_id":"9452","intvolume":"       328","volume":328,"year":"2010","keyword":["Multidisciplinary"],"type":"journal_article","day":"14","month":"05","article_processing_charge":"No","pmid":1,"date_updated":"2021-12-14T08:35:37Z","extern":"1","date_published":"2010-05-14T00:00:00Z","publication_status":"published","issue":"5980","department":[{"_id":"DaZi"}],"abstract":[{"lang":"eng","text":"Eukaryotic cytosine methylation represses transcription but also occurs in the bodies of active genes, and the extent of methylation biology conservation is unclear. We quantified DNA methylation in 17 eukaryotic genomes and found that gene body methylation is conserved between plants and animals, whereas selective methylation of transposons is not. We show that methylation of plant transposons in the CHG context extends to green algae and that exclusion of histone H2A.Z from methylated DNA is conserved between plants and animals, and we present evidence for RNA-directed DNA methylation of fungal genes. Our data demonstrate that extant DNA methylation systems are mosaics of conserved and derived features, and indicate that gene body methylation is an ancient property of eukaryotic genomes."}],"oa_version":"None","date_created":"2021-06-04T08:26:08Z","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","publisher":"American Association for the Advancement of Science","scopus_import":"1","title":"Genome-wide evolutionary analysis of eukaryotic DNA methylation","quality_controlled":"1","status":"public"}