{"intvolume":"       109","language":[{"iso":"eng"}],"volume":109,"date_updated":"2021-01-12T08:21:56Z","publist_id":"6519","type":"journal_article","extern":"1","issue":"1","publication_status":"published","publication":"Physical Review Letters","oa_version":"Preprint","abstract":[{"text":"We study theoretically the morphologies of biological tubes affected by various pathologies. When epithelial cells grow, the negative tension produced by their division provokes a buckling instability. Several shapes are investigated: varicose, dilated, sinuous, or sausagelike. They are all found in pathologies of tracheal, renal tubes, or arteries. The final shape depends crucially on the mechanical parameters of the tissues: Young's modulus, wall-to-lumen ratio, homeostatic pressure. We argue that since tissues must be in quasistatic mechanical equilibrium, abnormal shapes convey information as to what causes the pathology. We calculate a phase diagram of tubular instabilities which could be a helpful guide for investigating the underlying genetic regulation.","lang":"eng"}],"doi":"10.1103/PhysRevLett.109.018101","author":[{"last_name":"Hannezo","id":"3A9DB764-F248-11E8-B48F-1D18A9856A87","full_name":"Hannezo, Edouard B","first_name":"Edouard B","orcid":"0000-0001-6005-1561"},{"last_name":"Prost","first_name":"Jacques","full_name":"Prost, Jacques"},{"last_name":"Joanny","first_name":"Jean","full_name":"Joanny, Jean"}],"_id":"922","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1207.1516"}],"title":"Mechanical instabilities of biological tubes","citation":{"ieee":"E. B. Hannezo, J. Prost, and J. Joanny, “Mechanical instabilities of biological tubes,” <i>Physical Review Letters</i>, vol. 109, no. 1. American Physical Society, 2012.","short":"E.B. Hannezo, J. Prost, J. Joanny, Physical Review Letters 109 (2012).","ama":"Hannezo EB, Prost J, Joanny J. Mechanical instabilities of biological tubes. <i>Physical Review Letters</i>. 2012;109(1). doi:<a href=\"https://doi.org/10.1103/PhysRevLett.109.018101\">10.1103/PhysRevLett.109.018101</a>","mla":"Hannezo, Edouard B., et al. “Mechanical Instabilities of Biological Tubes.” <i>Physical Review Letters</i>, vol. 109, no. 1, American Physical Society, 2012, doi:<a href=\"https://doi.org/10.1103/PhysRevLett.109.018101\">10.1103/PhysRevLett.109.018101</a>.","apa":"Hannezo, E. B., Prost, J., &#38; Joanny, J. (2012). Mechanical instabilities of biological tubes. <i>Physical Review Letters</i>. American Physical Society. <a href=\"https://doi.org/10.1103/PhysRevLett.109.018101\">https://doi.org/10.1103/PhysRevLett.109.018101</a>","ista":"Hannezo EB, Prost J, Joanny J. 2012. Mechanical instabilities of biological tubes. Physical Review Letters. 109(1).","chicago":"Hannezo, Edouard B, Jacques Prost, and Jean Joanny. “Mechanical Instabilities of Biological Tubes.” <i>Physical Review Letters</i>. American Physical Society, 2012. <a href=\"https://doi.org/10.1103/PhysRevLett.109.018101\">https://doi.org/10.1103/PhysRevLett.109.018101</a>."},"date_created":"2018-12-11T11:49:13Z","month":"07","article_processing_charge":"No","date_published":"2012-07-03T00:00:00Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1,"status":"public","publisher":"American Physical Society","year":"2012","external_id":{"arxiv":["1207.1516"]},"day":"03"}