{"oa":1,"oa_version":"Published Version","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","date_created":"2020-11-08T23:01:25Z","publisher":"eLife Sciences Publications","scopus_import":"1","title":"Optogenetic inhibition-mediated activity-dependent modification of CA1 pyramidal-interneuron connections during behavior","quality_controlled":"1","related_material":{"record":[{"id":"8563","relation":"research_data","status":"public"}]},"status":"public","file":[{"date_updated":"2020-11-09T09:17:40Z","date_created":"2020-11-09T09:17:40Z","file_size":447669,"success":1,"file_id":"8749","checksum":"6a7b0543c440f4c000a1864e69377d95","relation":"main_file","creator":"dernst","access_level":"open_access","file_name":"2020_eLife_Gridchyn.pdf","content_type":"application/pdf"}],"type":"journal_article","day":"05","article_processing_charge":"No","month":"10","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"date_updated":"2024-02-21T12:43:40Z","publication_status":"published","date_published":"2020-10-05T00:00:00Z","department":[{"_id":"JoCs"}],"abstract":[{"lang":"eng","text":"In vitro work revealed that excitatory synaptic inputs to hippocampal inhibitory interneurons could undergo Hebbian, associative, or non-associative plasticity. Both behavioral and learning-dependent reorganization of these connections has also been demonstrated by measuring spike transmission probabilities in pyramidal cell-interneuron spike cross-correlations that indicate monosynaptic connections. Here we investigated the activity-dependent modification of these connections during exploratory behavior in rats by optogenetically inhibiting pyramidal cell and interneuron subpopulations. Light application and associated firing alteration of pyramidal and interneuron populations led to lasting changes in pyramidal-interneuron connection weights as indicated by spike transmission changes. Spike transmission alterations were predicted by the light-mediated changes in the number of pre- and postsynaptic spike pairing events and by firing rate changes of interneurons but not pyramidal cells. This work demonstrates the presence of activity-dependent associative and non-associative reorganization of pyramidal-interneuron connections triggered by the optogenetic modification of the firing rate and spike synchrony of cells."}],"intvolume":"         9","volume":9,"year":"2020","file_date_updated":"2020-11-09T09:17:40Z","isi":1,"acknowledgement":"We thank Michele Nardin and Federico Stella for comments on an earlier version of the manuscript. K Deisseroth for providing the pAAV-CaMKIIα::eNpHR3.0-YFP plasmid through Addgene. E Boyden for providing AAV2/1.CaMKII::ArchT.GFP.WPRE.SV40 plasmid through Penn Vector Core. This work was supported by the Austrian Science Fund (I02072 and I03713) and a Swiss National Science Foundation grant to PS. The authors declare no conflicts of interest.","ddc":["570"],"project":[{"call_identifier":"FWF","_id":"257D4372-B435-11E9-9278-68D0E5697425","name":"Interneuron plasticity during spatial learning","grant_number":"I2072-B27"},{"_id":"2654F984-B435-11E9-9278-68D0E5697425","name":"Interneuro Plasticity During Spatial Learning","grant_number":"I03713","call_identifier":"FWF"}],"doi":"10.7554/eLife.61106","publication":"eLife","author":[{"orcid":"0000-0002-1807-1929","last_name":"Gridchyn","first_name":"Igor","id":"4B60654C-F248-11E8-B48F-1D18A9856A87","full_name":"Gridchyn, Igor"},{"full_name":"Schönenberger, Philipp","id":"3B9D816C-F248-11E8-B48F-1D18A9856A87","first_name":"Philipp","last_name":"Schönenberger"},{"last_name":"O'Neill","first_name":"Joseph","full_name":"O'Neill, Joseph","id":"426376DC-F248-11E8-B48F-1D18A9856A87"},{"orcid":"0000-0002-5193-4036","full_name":"Csicsvari, Jozsef L","id":"3FA14672-F248-11E8-B48F-1D18A9856A87","first_name":"Jozsef L","last_name":"Csicsvari"}],"has_accepted_license":"1","external_id":{"isi":["000584369000001"]},"publication_identifier":{"eissn":["2050084X"]},"article_type":"original","citation":{"short":"I. Gridchyn, P. Schönenberger, J. O’Neill, J.L. Csicsvari, ELife 9 (2020).","ama":"Gridchyn I, Schönenberger P, O’Neill J, Csicsvari JL. Optogenetic inhibition-mediated activity-dependent modification of CA1 pyramidal-interneuron connections during behavior. <i>eLife</i>. 2020;9. doi:<a href=\"https://doi.org/10.7554/eLife.61106\">10.7554/eLife.61106</a>","apa":"Gridchyn, I., Schönenberger, P., O’Neill, J., &#38; Csicsvari, J. L. (2020). Optogenetic inhibition-mediated activity-dependent modification of CA1 pyramidal-interneuron connections during behavior. <i>ELife</i>. eLife Sciences Publications. <a href=\"https://doi.org/10.7554/eLife.61106\">https://doi.org/10.7554/eLife.61106</a>","ista":"Gridchyn I, Schönenberger P, O’Neill J, Csicsvari JL. 2020. Optogenetic inhibition-mediated activity-dependent modification of CA1 pyramidal-interneuron connections during behavior. eLife. 9, 61106.","chicago":"Gridchyn, Igor, Philipp Schönenberger, Joseph O’Neill, and Jozsef L Csicsvari. “Optogenetic Inhibition-Mediated Activity-Dependent Modification of CA1 Pyramidal-Interneuron Connections during Behavior.” <i>ELife</i>. eLife Sciences Publications, 2020. <a href=\"https://doi.org/10.7554/eLife.61106\">https://doi.org/10.7554/eLife.61106</a>.","ieee":"I. Gridchyn, P. Schönenberger, J. O’Neill, and J. L. Csicsvari, “Optogenetic inhibition-mediated activity-dependent modification of CA1 pyramidal-interneuron connections during behavior,” <i>eLife</i>, vol. 9. eLife Sciences Publications, 2020.","mla":"Gridchyn, Igor, et al. “Optogenetic Inhibition-Mediated Activity-Dependent Modification of CA1 Pyramidal-Interneuron Connections during Behavior.” <i>ELife</i>, vol. 9, 61106, eLife Sciences Publications, 2020, doi:<a href=\"https://doi.org/10.7554/eLife.61106\">10.7554/eLife.61106</a>."},"language":[{"iso":"eng"}],"article_number":"61106","_id":"8740"}