{"title":"The evolution of gene expression by copy number and point mutations","status":"public","related_material":{"record":[{"id":"7652","relation":"research_data","status":"public"}]},"alternative_title":["ISTA Thesis"],"oa_version":"Published Version","oa":1,"date_created":"2020-10-13T13:02:33Z","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","publisher":"Institute of Science and Technology Austria","date_published":"2020-10-13T00:00:00Z","publication_status":"published","department":[{"_id":"CaGu"}],"abstract":[{"lang":"eng","text":"Mutations are the raw material of evolution and come in many different flavors. Point mutations change a single letter in the DNA sequence, while copy number mutations like duplications or deletions add or remove many letters of the DNA sequence simultaneously.  Each type of mutation exhibits specific properties like its rate of formation and reversal. \r\nGene expression is a fundamental phenotype that can be altered by both, point and copy number mutations. The following thesis is concerned with the dynamics of gene expression evolution and how it is affected by the properties exhibited by point and copy number mutations. Specifically, we are considering i) copy number mutations during adaptation to fluctuating environments and ii) the interaction of copy number and point mutations during adaptation to constant environments.  "}],"type":"dissertation","file":[{"date_updated":"2021-10-20T22:30:03Z","date_created":"2020-10-16T12:14:21Z","file_size":25131884,"file_id":"8666","checksum":"c01d9f59794b4b70528f37637c17ad02","relation":"source_file","embargo_to":"open_access","access_level":"closed","creator":"itomanek","file_name":"Thesis_ITomanek_final_201016.docx","content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document"},{"relation":"main_file","checksum":"f8edbc3b0f81a780e13ca1e561d42d8b","embargo":"2021-10-19","file_name":"Thesis_ITomanek_final_201016.pdf","access_level":"open_access","creator":"itomanek","content_type":"application/pdf","date_updated":"2021-10-20T22:30:03Z","date_created":"2020-10-16T12:14:21Z","file_size":15405675,"file_id":"8667"}],"day":"13","degree_awarded":"PhD","article_processing_charge":"No","month":"10","supervisor":[{"full_name":"Guet, Calin C","id":"47F8433E-F248-11E8-B48F-1D18A9856A87","first_name":"Calin C","last_name":"Guet","orcid":"0000-0001-6220-2052"}],"date_updated":"2023-09-07T13:22:42Z","keyword":["duplication","amplification","promoter","CNV","AMGET","experimental evolution","Escherichia coli"],"file_date_updated":"2021-10-20T22:30:03Z","ddc":["576"],"year":"2020","citation":{"ama":"Tomanek I. The evolution of gene expression by copy number and point mutations. 2020. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:8653\">10.15479/AT:ISTA:8653</a>","chicago":"Tomanek, Isabella. “The Evolution of Gene Expression by Copy Number and Point Mutations.” Institute of Science and Technology Austria, 2020. <a href=\"https://doi.org/10.15479/AT:ISTA:8653\">https://doi.org/10.15479/AT:ISTA:8653</a>.","ista":"Tomanek I. 2020. The evolution of gene expression by copy number and point mutations. Institute of Science and Technology Austria.","apa":"Tomanek, I. (2020). <i>The evolution of gene expression by copy number and point mutations</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:8653\">https://doi.org/10.15479/AT:ISTA:8653</a>","short":"I. Tomanek, The Evolution of Gene Expression by Copy Number and Point Mutations, Institute of Science and Technology Austria, 2020.","mla":"Tomanek, Isabella. <i>The Evolution of Gene Expression by Copy Number and Point Mutations</i>. Institute of Science and Technology Austria, 2020, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:8653\">10.15479/AT:ISTA:8653</a>.","ieee":"I. Tomanek, “The evolution of gene expression by copy number and point mutations,” Institute of Science and Technology Austria, 2020."},"_id":"8653","language":[{"iso":"eng"}],"has_accepted_license":"1","author":[{"last_name":"Tomanek","first_name":"Isabella","id":"3981F020-F248-11E8-B48F-1D18A9856A87","full_name":"Tomanek, Isabella","orcid":"0000-0001-6197-363X"}],"page":"117","doi":"10.15479/AT:ISTA:8653","publication_identifier":{"issn":["2663-337X"]}}