{"isi":1,"acknowledgement":"This project was funded by an SNSF Eccellenza Grant to MRR (PCEGP3-181181), and by core funding from the Institute of Science and Technology Austria. We would like to thank the participants of the cohort studies, and the Ecole Polytechnique Federal Lausanne (EPFL) SCITAS for their excellent compute resources, their generosity with their time and the kindness of their support. P.M.V. acknowledges funding from the Australian National Health and Medical Research Council (1113400) and the Australian Research Council (FL180100072). L.R. acknowledges funding from the Kjell & Märta Beijer Foundation (Stockholm, Sweden). We also would like to acknowledge Simone Rubinacci, Oliver Delanau, Alexander Terenin, Eleonora Porcu, and Mike Goddard for their useful comments and suggestions.","file_date_updated":"2021-12-06T07:47:11Z","ddc":["610"],"volume":12,"intvolume":"        12","year":"2021","article_type":"original","citation":{"short":"M. Patxot, D. Trejo Banos, A. Kousathanas, E.J. Orliac, S.E. Ojavee, G. Moser, J. Sidorenko, Z. Kutalik, R. Magi, P.M. Visscher, L. Ronnegard, M.R. Robinson, Nature Communications 12 (2021).","ista":"Patxot M, Trejo Banos D, Kousathanas A, Orliac EJ, Ojavee SE, Moser G, Sidorenko J, Kutalik Z, Magi R, Visscher PM, Ronnegard L, Robinson MR. 2021. Probabilistic inference of the genetic architecture underlying functional enrichment of complex traits. Nature Communications. 12(1), 6972.","chicago":"Patxot, Marion, Daniel Trejo Banos, Athanasios Kousathanas, Etienne J Orliac, Sven E Ojavee, Gerhard Moser, Julia Sidorenko, et al. “Probabilistic Inference of the Genetic Architecture Underlying Functional Enrichment of Complex Traits.” <i>Nature Communications</i>. Springer Nature, 2021. <a href=\"https://doi.org/10.1038/s41467-021-27258-9\">https://doi.org/10.1038/s41467-021-27258-9</a>.","apa":"Patxot, M., Trejo Banos, D., Kousathanas, A., Orliac, E. J., Ojavee, S. E., Moser, G., … Robinson, M. R. (2021). Probabilistic inference of the genetic architecture underlying functional enrichment of complex traits. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-021-27258-9\">https://doi.org/10.1038/s41467-021-27258-9</a>","ama":"Patxot M, Trejo Banos D, Kousathanas A, et al. Probabilistic inference of the genetic architecture underlying functional enrichment of complex traits. <i>Nature Communications</i>. 2021;12(1). doi:<a href=\"https://doi.org/10.1038/s41467-021-27258-9\">10.1038/s41467-021-27258-9</a>","ieee":"M. Patxot <i>et al.</i>, “Probabilistic inference of the genetic architecture underlying functional enrichment of complex traits,” <i>Nature Communications</i>, vol. 12, no. 1. Springer Nature, 2021.","mla":"Patxot, Marion, et al. “Probabilistic Inference of the Genetic Architecture Underlying Functional Enrichment of Complex Traits.” <i>Nature Communications</i>, vol. 12, no. 1, 6972, Springer Nature, 2021, doi:<a href=\"https://doi.org/10.1038/s41467-021-27258-9\">10.1038/s41467-021-27258-9</a>."},"_id":"8429","article_number":"6972","language":[{"iso":"eng"}],"has_accepted_license":"1","author":[{"full_name":"Patxot, Marion","first_name":"Marion","last_name":"Patxot"},{"first_name":"Daniel","last_name":"Trejo Banos","full_name":"Trejo Banos, Daniel"},{"first_name":"Athanasios","last_name":"Kousathanas","full_name":"Kousathanas, Athanasios"},{"first_name":"Etienne J","last_name":"Orliac","full_name":"Orliac, Etienne J"},{"last_name":"Ojavee","first_name":"Sven E","full_name":"Ojavee, Sven E"},{"last_name":"Moser","first_name":"Gerhard","full_name":"Moser, Gerhard"},{"full_name":"Sidorenko, Julia","last_name":"Sidorenko","first_name":"Julia"},{"last_name":"Kutalik","first_name":"Zoltan","full_name":"Kutalik, Zoltan"},{"full_name":"Magi, Reedik","first_name":"Reedik","last_name":"Magi"},{"full_name":"Visscher, Peter M","first_name":"Peter M","last_name":"Visscher"},{"full_name":"Ronnegard, Lars","last_name":"Ronnegard","first_name":"Lars"},{"first_name":"Matthew Richard","last_name":"Robinson","id":"E5D42276-F5DA-11E9-8E24-6303E6697425","full_name":"Robinson, Matthew Richard","orcid":"0000-0001-8982-8813"}],"publication":"Nature Communications","doi":"10.1038/s41467-021-27258-9","publication_identifier":{"eissn":["2041-1723"]},"external_id":{"isi":["000724450600023"]},"status":"public","related_material":{"record":[{"status":"public","id":"13063","relation":"research_data"}]},"title":"Probabilistic inference of the genetic architecture underlying functional enrichment of complex traits","quality_controlled":"1","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","date_created":"2020-09-17T10:52:38Z","oa_version":"Published Version","oa":1,"scopus_import":"1","publisher":"Springer Nature","issue":"1","publication_status":"published","date_published":"2021-11-30T00:00:00Z","abstract":[{"text":"We develop a Bayesian model (BayesRR-RC) that provides robust SNP-heritability estimation, an alternative to marker discovery, and accurate genomic prediction, taking 22 seconds per iteration to estimate 8.4 million SNP-effects and 78 SNP-heritability parameters in the UK Biobank. We find that only ≤10% of the genetic variation captured for height, body mass index, cardiovascular disease, and type 2 diabetes is attributable to proximal regulatory regions within 10kb upstream of genes, while 12-25% is attributed to coding regions, 32–44% to introns, and 22-28% to distal 10-500kb upstream regions. Up to 24% of all cis and coding regions of each chromosome are associated with each trait, with over 3,100 independent exonic and intronic regions and over 5,400 independent regulatory regions having ≥95% probability of contributing ≥0.001% to the genetic variance of these four traits. Our open-source software (GMRM) provides a scalable alternative to current approaches for biobank data.","lang":"eng"}],"department":[{"_id":"MaRo"}],"day":"30","type":"journal_article","file":[{"content_type":"application/pdf","file_name":"2021_NatComm_Paxtot.pdf","creator":"cchlebak","access_level":"open_access","relation":"main_file","checksum":"384681be17aff902c149a48f52d13d4f","file_id":"10419","success":1,"file_size":6519771,"date_created":"2021-12-06T07:47:11Z","date_updated":"2021-12-06T07:47:11Z"}],"date_updated":"2023-09-26T10:36:14Z","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"month":"11","article_processing_charge":"No"}