{"language":[{"iso":"eng"}],"extern":"1","type":"preprint","date_updated":"2021-01-12T08:17:02Z","abstract":[{"lang":"eng","text":"The stimulus selectivity of synaptic currents in cortical neurons often shows a co-tuning of excitation and inhibition, but the mechanisms that underlie the emergence and plasticity of this co-tuning are not fully understood. Using a computational model, we show that an interaction of excitatory and inhibitory synaptic plasticity reproduces both the developmental and – when combined with a disinhibitory gate – the adult plasticity of excitatory and inhibitory receptive fields in auditory cortex. The co-tuning arises from inhibitory plasticity that balances excitation and inhibition, while excitatory stimulus selectivity can result from two different mechanisms. Inhibitory inputs with a broad stimulus tuning introduce a sliding threshold as in Bienenstock-Cooper-Munro rules, introducing an excitatory stimulus selectivity at the cost of a broader inhibitory receptive field. Alternatively, input asymmetries can be amplified by synaptic competition. The latter leaves any receptive field plasticity transient, a prediction we verify in recordings in auditory cortex."}],"oa_version":"Preprint","publication":"bioRxiv","publication_status":"published","title":"Receptive field formation by interacting excitatory and inhibitory synaptic plasticity","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1101/066589 "}],"_id":"8128","author":[{"last_name":"Clopath","full_name":"Clopath, Claudia","first_name":"Claudia"},{"id":"CB6FF8D2-008F-11EA-8E08-2637E6697425","last_name":"Vogels","orcid":"0000-0003-3295-6181","full_name":"Vogels, Tim P","first_name":"Tim P"},{"first_name":"Robert C.","full_name":"Froemke, Robert C.","last_name":"Froemke"},{"last_name":"Sprekeler","full_name":"Sprekeler, Henning","first_name":"Henning"}],"month":"07","date_created":"2020-07-16T12:26:55Z","citation":{"apa":"Clopath, C., Vogels, T. P., Froemke, R. C., &#38; Sprekeler, H. (2016). Receptive field formation by interacting excitatory and inhibitory synaptic plasticity. <i>bioRxiv</i>. Cold Spring Harbor Laboratory.","chicago":"Clopath, Claudia, Tim P Vogels, Robert C. Froemke, and Henning Sprekeler. “Receptive Field Formation by Interacting Excitatory and Inhibitory Synaptic Plasticity.” <i>BioRxiv</i>. Cold Spring Harbor Laboratory, 2016.","ista":"Clopath C, Vogels TP, Froemke RC, Sprekeler H. 2016. Receptive field formation by interacting excitatory and inhibitory synaptic plasticity. bioRxiv, .","ieee":"C. Clopath, T. P. Vogels, R. C. Froemke, and H. Sprekeler, “Receptive field formation by interacting excitatory and inhibitory synaptic plasticity,” <i>bioRxiv</i>. Cold Spring Harbor Laboratory, 2016.","short":"C. Clopath, T.P. Vogels, R.C. Froemke, H. Sprekeler, BioRxiv (2016).","mla":"Clopath, Claudia, et al. “Receptive Field Formation by Interacting Excitatory and Inhibitory Synaptic Plasticity.” <i>BioRxiv</i>, Cold Spring Harbor Laboratory, 2016.","ama":"Clopath C, Vogels TP, Froemke RC, Sprekeler H. Receptive field formation by interacting excitatory and inhibitory synaptic plasticity. <i>bioRxiv</i>. 2016."},"article_processing_charge":"No","oa":1,"user_id":"D865714E-FA4E-11E9-B85B-F5C5E5697425","date_published":"2016-07-29T00:00:00Z","day":"29","year":"2016","publisher":"Cold Spring Harbor Laboratory","status":"public","page":"43"}