{"date_updated":"2023-08-21T06:21:14Z","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"month":"04","article_processing_charge":"No","day":"29","type":"journal_article","file":[{"date_updated":"2020-07-14T12:48:03Z","date_created":"2020-05-11T10:36:33Z","file_size":4609120,"file_id":"7817","relation":"main_file","checksum":"dce367abf2c1a1d15f58fe6f7de82893","file_name":"2020_NatureComm_Flynn.pdf","creator":"dernst","access_level":"open_access","content_type":"application/pdf"}],"abstract":[{"text":"Besides pro-inflammatory roles, the ancient cytokine interleukin-17 (IL-17) modulates neural circuit function. We investigate IL-17 signaling in neurons, and the extent it can alter organismal phenotypes. We combine immunoprecipitation and mass spectrometry to biochemically characterize endogenous signaling complexes that function downstream of IL-17 receptors in C. elegans neurons. We identify the paracaspase MALT-1 as a critical output of the pathway. MALT1 mediates signaling from many immune receptors in mammals, but was not previously implicated in IL-17 signaling or nervous system function. C. elegans MALT-1 forms a complex with homologs of Act1 and IRAK and appears to function both as a scaffold and a protease. MALT-1 is expressed broadly in the C. elegans nervous system, and neuronal IL-17–MALT-1 signaling regulates multiple phenotypes, including escape behavior, associative learning, immunity and longevity. Our data suggest MALT1 has an ancient role modulating neural circuit function downstream of IL-17 to remodel physiology and behavior.","lang":"eng"}],"department":[{"_id":"MaDe"}],"publication_status":"published","date_published":"2020-04-29T00:00:00Z","scopus_import":"1","publisher":"Springer Nature","date_created":"2020-05-10T22:00:47Z","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","oa_version":"Published Version","oa":1,"status":"public","quality_controlled":"1","title":"MALT-1 mediates IL-17 neural signaling to regulate C. elegans behavior, immunity and longevity","publication_identifier":{"eissn":["20411723"]},"external_id":{"isi":["000531855500029"]},"publication":"Nature Communications","author":[{"last_name":"Flynn","first_name":"Sean M.","full_name":"Flynn, Sean M."},{"last_name":"Chen","first_name":"Changchun","full_name":"Chen, Changchun"},{"full_name":"Artan, Murat","id":"C407B586-6052-11E9-B3AE-7006E6697425","last_name":"Artan","first_name":"Murat","orcid":"0000-0001-8945-6992"},{"last_name":"Barratt","first_name":"Stephen","full_name":"Barratt, Stephen"},{"first_name":"Alastair","last_name":"Crisp","full_name":"Crisp, Alastair"},{"first_name":"Geoffrey M.","last_name":"Nelson","full_name":"Nelson, Geoffrey M."},{"last_name":"Peak-Chew","first_name":"Sew Yeu","full_name":"Peak-Chew, Sew Yeu"},{"full_name":"Begum, Farida","last_name":"Begum","first_name":"Farida"},{"full_name":"Skehel, Mark","last_name":"Skehel","first_name":"Mark"},{"orcid":"0000-0001-8347-0443","last_name":"De Bono","first_name":"Mario","id":"4E3FF80E-F248-11E8-B48F-1D18A9856A87","full_name":"De Bono, Mario"}],"has_accepted_license":"1","doi":"10.1038/s41467-020-15872-y","article_number":"2099","_id":"7804","language":[{"iso":"eng"}],"citation":{"mla":"Flynn, Sean M., et al. “MALT-1 Mediates IL-17 Neural Signaling to Regulate C. Elegans Behavior, Immunity and Longevity.” <i>Nature Communications</i>, vol. 11, 2099, Springer Nature, 2020, doi:<a href=\"https://doi.org/10.1038/s41467-020-15872-y\">10.1038/s41467-020-15872-y</a>.","ieee":"S. M. Flynn <i>et al.</i>, “MALT-1 mediates IL-17 neural signaling to regulate C. elegans behavior, immunity and longevity,” <i>Nature Communications</i>, vol. 11. Springer Nature, 2020.","apa":"Flynn, S. M., Chen, C., Artan, M., Barratt, S., Crisp, A., Nelson, G. M., … de Bono, M. (2020). MALT-1 mediates IL-17 neural signaling to regulate C. elegans behavior, immunity and longevity. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-020-15872-y\">https://doi.org/10.1038/s41467-020-15872-y</a>","ista":"Flynn SM, Chen C, Artan M, Barratt S, Crisp A, Nelson GM, Peak-Chew SY, Begum F, Skehel M, de Bono M. 2020. MALT-1 mediates IL-17 neural signaling to regulate C. elegans behavior, immunity and longevity. Nature Communications. 11, 2099.","chicago":"Flynn, Sean M., Changchun Chen, Murat Artan, Stephen Barratt, Alastair Crisp, Geoffrey M. Nelson, Sew Yeu Peak-Chew, Farida Begum, Mark Skehel, and Mario de Bono. “MALT-1 Mediates IL-17 Neural Signaling to Regulate C. Elegans Behavior, Immunity and Longevity.” <i>Nature Communications</i>. Springer Nature, 2020. <a href=\"https://doi.org/10.1038/s41467-020-15872-y\">https://doi.org/10.1038/s41467-020-15872-y</a>.","ama":"Flynn SM, Chen C, Artan M, et al. MALT-1 mediates IL-17 neural signaling to regulate C. elegans behavior, immunity and longevity. <i>Nature Communications</i>. 2020;11. doi:<a href=\"https://doi.org/10.1038/s41467-020-15872-y\">10.1038/s41467-020-15872-y</a>","short":"S.M. Flynn, C. Chen, M. Artan, S. Barratt, A. Crisp, G.M. Nelson, S.Y. Peak-Chew, F. Begum, M. Skehel, M. de Bono, Nature Communications 11 (2020)."},"article_type":"original","year":"2020","volume":11,"intvolume":"        11","ddc":["570"],"isi":1,"file_date_updated":"2020-07-14T12:48:03Z"}