{"title":"Evolutionary history and adaptation of a human pygmy population of Flores Island, Indonesia","quality_controlled":"1","issue":"6401","oa_version":"None","intvolume":"       361","language":[{"iso":"eng"}],"publisher":"American Association for the Advancement of Science","year":"2018","article_type":"original","day":"03","date_published":"2018-08-03T00:00:00Z","pmid":1,"doi":"10.1126/science.aar8486","author":[{"last_name":"Tucci","first_name":"Serena","full_name":"Tucci, Serena"},{"last_name":"Vohr","full_name":"Vohr, Samuel H.","first_name":"Samuel H."},{"last_name":"McCoy","first_name":"Rajiv C.","full_name":"McCoy, Rajiv C."},{"last_name":"Vernot","full_name":"Vernot, Benjamin","first_name":"Benjamin"},{"first_name":"Matthew Richard","full_name":"Robinson, Matthew Richard","orcid":"0000-0001-8982-8813","last_name":"Robinson","id":"E5D42276-F5DA-11E9-8E24-6303E6697425"},{"last_name":"Barbieri","first_name":"Chiara","full_name":"Barbieri, Chiara"},{"last_name":"Nelson","first_name":"Brad J.","full_name":"Nelson, Brad J."},{"last_name":"Fu","first_name":"Wenqing","full_name":"Fu, Wenqing"},{"last_name":"Purnomo","full_name":"Purnomo, Gludhug A.","first_name":"Gludhug A."},{"last_name":"Sudoyo","full_name":"Sudoyo, Herawati","first_name":"Herawati"},{"full_name":"Eichler, Evan E.","first_name":"Evan E.","last_name":"Eichler"},{"first_name":"Guido","full_name":"Barbujani, Guido","last_name":"Barbujani"},{"full_name":"Visscher, Peter M.","first_name":"Peter M.","last_name":"Visscher"},{"last_name":"Akey","full_name":"Akey, Joshua M.","first_name":"Joshua M."},{"last_name":"Green","first_name":"Richard E.","full_name":"Green, Richard E."}],"_id":"7718","publication_status":"published","publication":"Science","abstract":[{"text":"Flores Island, Indonesia, was inhabited by the small-bodied hominin species Homo floresiensis, which has an unknown evolutionary relationship to modern humans. This island is also home to an extant human pygmy population. Here we describe genome-scale single-nucleotide polymorphism data and whole-genome sequences from a contemporary human pygmy population living on Flores near the cave where H. floresiensis was found. The genomes of Flores pygmies reveal a complex history of admixture with Denisovans and Neanderthals but no evidence for gene flow with other archaic hominins. Modern individuals bear the signatures of recent positive selection encompassing the FADS (fatty acid desaturase) gene cluster, likely related to diet, and polygenic selection acting on standing variation that contributed to their short-stature phenotype. Thus, multiple independent instances of hominin insular dwarfism occurred on Flores.","lang":"eng"}],"volume":361,"date_updated":"2021-01-12T08:15:04Z","type":"journal_article","extern":"1","publication_identifier":{"issn":["0036-8075","1095-9203"]},"page":"511-516","status":"public","external_id":{"pmid":["30072539"]},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_processing_charge":"No","citation":{"chicago":"Tucci, Serena, Samuel H. Vohr, Rajiv C. McCoy, Benjamin Vernot, Matthew Richard Robinson, Chiara Barbieri, Brad J. Nelson, et al. “Evolutionary History and Adaptation of a Human Pygmy Population of Flores Island, Indonesia.” <i>Science</i>. American Association for the Advancement of Science, 2018. <a href=\"https://doi.org/10.1126/science.aar8486\">https://doi.org/10.1126/science.aar8486</a>.","ista":"Tucci S, Vohr SH, McCoy RC, Vernot B, Robinson MR, Barbieri C, Nelson BJ, Fu W, Purnomo GA, Sudoyo H, Eichler EE, Barbujani G, Visscher PM, Akey JM, Green RE. 2018. Evolutionary history and adaptation of a human pygmy population of Flores Island, Indonesia. Science. 361(6401), 511–516.","apa":"Tucci, S., Vohr, S. H., McCoy, R. C., Vernot, B., Robinson, M. R., Barbieri, C., … Green, R. E. (2018). Evolutionary history and adaptation of a human pygmy population of Flores Island, Indonesia. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.aar8486\">https://doi.org/10.1126/science.aar8486</a>","ama":"Tucci S, Vohr SH, McCoy RC, et al. Evolutionary history and adaptation of a human pygmy population of Flores Island, Indonesia. <i>Science</i>. 2018;361(6401):511-516. doi:<a href=\"https://doi.org/10.1126/science.aar8486\">10.1126/science.aar8486</a>","mla":"Tucci, Serena, et al. “Evolutionary History and Adaptation of a Human Pygmy Population of Flores Island, Indonesia.” <i>Science</i>, vol. 361, no. 6401, American Association for the Advancement of Science, 2018, pp. 511–16, doi:<a href=\"https://doi.org/10.1126/science.aar8486\">10.1126/science.aar8486</a>.","short":"S. Tucci, S.H. Vohr, R.C. McCoy, B. Vernot, M.R. Robinson, C. Barbieri, B.J. Nelson, W. Fu, G.A. Purnomo, H. Sudoyo, E.E. Eichler, G. Barbujani, P.M. Visscher, J.M. Akey, R.E. Green, Science 361 (2018) 511–516.","ieee":"S. Tucci <i>et al.</i>, “Evolutionary history and adaptation of a human pygmy population of Flores Island, Indonesia,” <i>Science</i>, vol. 361, no. 6401. American Association for the Advancement of Science, pp. 511–516, 2018."},"date_created":"2020-04-30T10:43:24Z","month":"08"}