{"abstract":[{"lang":"eng","text":"There are mean differences in complex traits among global human populations. We hypothesize that part of the phenotypic differentiation is due to natural selection. To address this hypothesis, we assess the differentiation in allele frequencies of trait-associated SNPs among African, Eastern Asian, and European populations for ten complex traits using data of large sample size (up to ~405,000). We show that SNPs associated with height (P=2.46×10−5), waist-to-hip ratio (P=2.77×10−4), and schizophrenia (P=3.96×10−5) are significantly more differentiated among populations than matched “control” SNPs, suggesting that these trait-associated SNPs have undergone natural selection. We further find that SNPs associated with height (P=2.01×10−6) and schizophrenia (P=5.16×10−18) show significantly higher variance in linkage disequilibrium (LD) scores across populations than control SNPs. Our results support the hypothesis that natural selection has shaped the genetic differentiation of complex traits, such as height and schizophrenia, among worldwide populations."}],"article_number":"1865","oa_version":"Published Version","publication":"Nature Communications","publication_status":"published","quality_controlled":"1","title":"Global genetic differentiation of complex traits shaped by natural selection in humans","_id":"7713","main_file_link":[{"url":"https://doi.org/10.1038/s41467-018-04191-y","open_access":"1"}],"author":[{"last_name":"Guo","first_name":"Jing","full_name":"Guo, Jing"},{"last_name":"Wu","first_name":"Yang","full_name":"Wu, Yang"},{"last_name":"Zhu","first_name":"Zhihong","full_name":"Zhu, Zhihong"},{"last_name":"Zheng","first_name":"Zhili","full_name":"Zheng, Zhili"},{"first_name":"Maciej","full_name":"Trzaskowski, Maciej","last_name":"Trzaskowski"},{"first_name":"Jian","full_name":"Zeng, Jian","last_name":"Zeng"},{"last_name":"Robinson","id":"E5D42276-F5DA-11E9-8E24-6303E6697425","first_name":"Matthew Richard","full_name":"Robinson, Matthew Richard","orcid":"0000-0001-8982-8813"},{"last_name":"Visscher","full_name":"Visscher, Peter M.","first_name":"Peter M."},{"last_name":"Yang","full_name":"Yang, Jian","first_name":"Jian"}],"doi":"10.1038/s41467-018-04191-y","language":[{"iso":"eng"}],"publication_identifier":{"issn":["2041-1723"]},"intvolume":"         9","extern":"1","type":"journal_article","date_updated":"2021-01-12T08:15:02Z","volume":9,"oa":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_published":"2018-05-14T00:00:00Z","day":"14","status":"public","year":"2018","article_type":"original","publisher":"Springer Nature","month":"05","date_created":"2020-04-30T10:41:36Z","citation":{"mla":"Guo, Jing, et al. “Global Genetic Differentiation of Complex Traits Shaped by Natural Selection in Humans.” <i>Nature Communications</i>, vol. 9, 1865, Springer Nature, 2018, doi:<a href=\"https://doi.org/10.1038/s41467-018-04191-y\">10.1038/s41467-018-04191-y</a>.","ama":"Guo J, Wu Y, Zhu Z, et al. Global genetic differentiation of complex traits shaped by natural selection in humans. <i>Nature Communications</i>. 2018;9. doi:<a href=\"https://doi.org/10.1038/s41467-018-04191-y\">10.1038/s41467-018-04191-y</a>","short":"J. Guo, Y. Wu, Z. Zhu, Z. Zheng, M. Trzaskowski, J. Zeng, M.R. Robinson, P.M. Visscher, J. Yang, Nature Communications 9 (2018).","ieee":"J. Guo <i>et al.</i>, “Global genetic differentiation of complex traits shaped by natural selection in humans,” <i>Nature Communications</i>, vol. 9. Springer Nature, 2018.","ista":"Guo J, Wu Y, Zhu Z, Zheng Z, Trzaskowski M, Zeng J, Robinson MR, Visscher PM, Yang J. 2018. Global genetic differentiation of complex traits shaped by natural selection in humans. Nature Communications. 9, 1865.","chicago":"Guo, Jing, Yang Wu, Zhihong Zhu, Zhili Zheng, Maciej Trzaskowski, Jian Zeng, Matthew Richard Robinson, Peter M. Visscher, and Jian Yang. “Global Genetic Differentiation of Complex Traits Shaped by Natural Selection in Humans.” <i>Nature Communications</i>. Springer Nature, 2018. <a href=\"https://doi.org/10.1038/s41467-018-04191-y\">https://doi.org/10.1038/s41467-018-04191-y</a>.","apa":"Guo, J., Wu, Y., Zhu, Z., Zheng, Z., Trzaskowski, M., Zeng, J., … Yang, J. (2018). Global genetic differentiation of complex traits shaped by natural selection in humans. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-018-04191-y\">https://doi.org/10.1038/s41467-018-04191-y</a>"},"article_processing_charge":"No"}