{"page":"734-747","status":"public","article_type":"original","year":"2011","publisher":"Elsevier","day":"08","date_published":"2011-12-08T00:00:00Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_processing_charge":"No","citation":{"ieee":"L. B. Sweeney <i>et al.</i>, “Secreted semaphorins from degenerating larval ORN axons direct adult projection neuron dendrite targeting,” <i>Neuron</i>, vol. 72, no. 5. Elsevier, pp. 734–747, 2011.","mla":"Sweeney, Lora B., et al. “Secreted Semaphorins from Degenerating Larval ORN Axons Direct Adult Projection Neuron Dendrite Targeting.” <i>Neuron</i>, vol. 72, no. 5, Elsevier, 2011, pp. 734–47, doi:<a href=\"https://doi.org/10.1016/j.neuron.2011.09.026\">10.1016/j.neuron.2011.09.026</a>.","ama":"Sweeney LB, Chou Y-H, Wu Z, et al. Secreted semaphorins from degenerating larval ORN axons direct adult projection neuron dendrite targeting. <i>Neuron</i>. 2011;72(5):734-747. doi:<a href=\"https://doi.org/10.1016/j.neuron.2011.09.026\">10.1016/j.neuron.2011.09.026</a>","short":"L.B. Sweeney, Y.-H. Chou, Z. Wu, W. Joo, T. Komiyama, C.J. Potter, A.L. Kolodkin, K.C. Garcia, L. Luo, Neuron 72 (2011) 734–747.","apa":"Sweeney, L. B., Chou, Y.-H., Wu, Z., Joo, W., Komiyama, T., Potter, C. J., … Luo, L. (2011). Secreted semaphorins from degenerating larval ORN axons direct adult projection neuron dendrite targeting. <i>Neuron</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.neuron.2011.09.026\">https://doi.org/10.1016/j.neuron.2011.09.026</a>","ista":"Sweeney LB, Chou Y-H, Wu Z, Joo W, Komiyama T, Potter CJ, Kolodkin AL, Garcia KC, Luo L. 2011. Secreted semaphorins from degenerating larval ORN axons direct adult projection neuron dendrite targeting. Neuron. 72(5), 734–747.","chicago":"Sweeney, Lora B., Ya-Hui Chou, Zhuhao Wu, William Joo, Takaki Komiyama, Christopher J. Potter, Alex L. Kolodkin, K. Christopher Garcia, and Liqun Luo. “Secreted Semaphorins from Degenerating Larval ORN Axons Direct Adult Projection Neuron Dendrite Targeting.” <i>Neuron</i>. Elsevier, 2011. <a href=\"https://doi.org/10.1016/j.neuron.2011.09.026\">https://doi.org/10.1016/j.neuron.2011.09.026</a>."},"date_created":"2020-04-30T10:36:12Z","month":"12","doi":"10.1016/j.neuron.2011.09.026","author":[{"last_name":"Sweeney","id":"56BE8254-C4F0-11E9-8E45-0B23E6697425","full_name":"Sweeney, Lora Beatrice Jaeger","first_name":"Lora Beatrice Jaeger","orcid":"0000-0001-9242-5601"},{"full_name":"Chou, Ya-Hui","first_name":"Ya-Hui","last_name":"Chou"},{"full_name":"Wu, Zhuhao","first_name":"Zhuhao","last_name":"Wu"},{"first_name":"William","full_name":"Joo, William","last_name":"Joo"},{"last_name":"Komiyama","full_name":"Komiyama, Takaki","first_name":"Takaki"},{"full_name":"Potter, Christopher J.","first_name":"Christopher J.","last_name":"Potter"},{"first_name":"Alex L.","full_name":"Kolodkin, Alex L.","last_name":"Kolodkin"},{"first_name":"K. Christopher","full_name":"Garcia, K. Christopher","last_name":"Garcia"},{"last_name":"Luo","first_name":"Liqun","full_name":"Luo, Liqun"}],"_id":"7701","title":"Secreted semaphorins from degenerating larval ORN axons direct adult projection neuron dendrite targeting","quality_controlled":"1","publication":"Neuron","issue":"5","publication_status":"published","abstract":[{"lang":"eng","text":"During assembly of the Drosophila olfactory circuit, projection neuron (PN) dendrites prepattern the developing antennal lobe before the arrival of axons from their presynaptic partners, the adult olfactory receptor neurons (ORNs). We previously found that levels of transmembrane Semaphorin-1a, which acts as a receptor, instruct PN dendrite targeting along the dorsolateral-ventromedial axis. Here we show that two secreted semaphorins, Sema-2a and Sema-2b, provide spatial cues for PN dendrite targeting. Sema-2a and Sema-2b proteins are distributed in gradients opposing the Sema-1a protein gradient, and Sema-1a binds to Sema-2a-expressing cells. In Sema-2a and Sema-2b double mutants, PN dendrites that normally target dorsolaterally in the antennal lobe mistarget ventromedially, phenocopying cell-autonomous Sema-1a removal from these PNs. Cell ablation, cell-specific knockdown, and rescue experiments indicate that secreted semaphorins from degenerating larval ORN axons direct dendrite targeting. Thus, a degenerating brain structure instructs the wiring of a developing circuit through the repulsive action of secreted semaphorins."}],"oa_version":"None","volume":72,"date_updated":"2024-01-31T10:13:39Z","type":"journal_article","extern":"1","intvolume":"        72","publication_identifier":{"issn":["0896-6273"]},"language":[{"iso":"eng"}]}