{"department":[{"_id":"EdHa"}],"abstract":[{"lang":"eng","text":"The morphogenesis of branched organs remains a subject of abiding interest. Although much is known about the underlying signaling pathways, it remains unclear how macroscopic features of branched organs, including their size, network topology, and spatial patterning, are encoded. Here, we show that, in mouse mammary gland, kidney, and human prostate, these features can be explained quantitatively within a single unifying framework of branching and annihilating random walks. Based on quantitative analyses of large-scale organ reconstructions and proliferation kinetics measurements, we propose that morphogenesis follows from the proliferative activity of equipotent tips that stochastically branch and randomly explore their environment but compete neutrally for space, becoming proliferatively inactive when in proximity with neighboring ducts. These results show that complex branched epithelial structures develop as a self-organized process, reliant upon a strikingly simple but generic rule, without recourse to a rigid and deterministic sequence of genetically programmed events."}],"date_published":"2017-09-21T00:00:00Z","publication_status":"published","issue":"1","article_processing_charge":"No","month":"09","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"date_updated":"2023-09-28T11:34:17Z","file":[{"access_level":"open_access","creator":"system","file_name":"IST-2017-883-v1+1_PIIS0092867417309510.pdf","content_type":"application/pdf","checksum":"7a036d93a9e2e597af9bb504d6133aca","relation":"main_file","date_created":"2018-12-12T10:11:17Z","file_size":12670204,"file_id":"4870","date_updated":"2020-07-14T12:47:55Z"}],"type":"journal_article","day":"21","quality_controlled":"1","title":"A unifying theory of branching morphogenesis","status":"public","publisher":"Cell Press","scopus_import":"1","oa":1,"oa_version":"Published Version","date_created":"2018-12-11T11:48:10Z","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","pubrep_id":"883","language":[{"iso":"eng"}],"_id":"726","citation":{"ieee":"E. B. Hannezo <i>et al.</i>, “A unifying theory of branching morphogenesis,” <i>Cell</i>, vol. 171, no. 1. Cell Press, pp. 242–255, 2017.","mla":"Hannezo, Edouard B., et al. “A Unifying Theory of Branching Morphogenesis.” <i>Cell</i>, vol. 171, no. 1, Cell Press, 2017, pp. 242–55, doi:<a href=\"https://doi.org/10.1016/j.cell.2017.08.026\">10.1016/j.cell.2017.08.026</a>.","short":"E.B. Hannezo, C. Scheele, M. Moad, N. Drogo, R. Heer, R. Sampogna, J. Van Rheenen, B. Simons, Cell 171 (2017) 242–255.","ama":"Hannezo EB, Scheele C, Moad M, et al. A unifying theory of branching morphogenesis. <i>Cell</i>. 2017;171(1):242-255. doi:<a href=\"https://doi.org/10.1016/j.cell.2017.08.026\">10.1016/j.cell.2017.08.026</a>","chicago":"Hannezo, Edouard B, Colinda Scheele, Mohammad Moad, Nicholas Drogo, Rakesh Heer, Rosemary Sampogna, Jacco Van Rheenen, and Benjamin Simons. “A Unifying Theory of Branching Morphogenesis.” <i>Cell</i>. Cell Press, 2017. <a href=\"https://doi.org/10.1016/j.cell.2017.08.026\">https://doi.org/10.1016/j.cell.2017.08.026</a>.","ista":"Hannezo EB, Scheele C, Moad M, Drogo N, Heer R, Sampogna R, Van Rheenen J, Simons B. 2017. A unifying theory of branching morphogenesis. Cell. 171(1), 242–255.","apa":"Hannezo, E. B., Scheele, C., Moad, M., Drogo, N., Heer, R., Sampogna, R., … Simons, B. (2017). A unifying theory of branching morphogenesis. <i>Cell</i>. Cell Press. <a href=\"https://doi.org/10.1016/j.cell.2017.08.026\">https://doi.org/10.1016/j.cell.2017.08.026</a>"},"external_id":{"isi":["000411331800024"]},"publication_identifier":{"issn":["00928674"]},"doi":"10.1016/j.cell.2017.08.026","page":"242 - 255","author":[{"id":"3A9DB764-F248-11E8-B48F-1D18A9856A87","full_name":"Hannezo, Edouard B","first_name":"Edouard B","last_name":"Hannezo","orcid":"0000-0001-6005-1561"},{"full_name":"Scheele, Colinda","last_name":"Scheele","first_name":"Colinda"},{"full_name":"Moad, Mohammad","last_name":"Moad","first_name":"Mohammad"},{"first_name":"Nicholas","last_name":"Drogo","full_name":"Drogo, Nicholas"},{"full_name":"Heer, Rakesh","first_name":"Rakesh","last_name":"Heer"},{"full_name":"Sampogna, Rosemary","first_name":"Rosemary","last_name":"Sampogna"},{"first_name":"Jacco","last_name":"Van Rheenen","full_name":"Van Rheenen, Jacco"},{"last_name":"Simons","first_name":"Benjamin","full_name":"Simons, Benjamin"}],"publication":"Cell","has_accepted_license":"1","ddc":["539"],"file_date_updated":"2020-07-14T12:47:55Z","isi":1,"year":"2017","intvolume":"       171","publist_id":"6952","volume":171}