{"issue":"8","citation":{"mla":"Geng, Xiaoqi, et al. “Roles of Afadin in Functional Differentiations of Hippocampal Mossy Fiber Synapse.” <i>Genes to Cells</i>, vol. 22, no. 8, Wiley-Blackwell, 2017, pp. 715–22, doi:<a href=\"https://doi.org/10.1111/gtc.12508\">10.1111/gtc.12508</a>.","ieee":"X. Geng <i>et al.</i>, “Roles of afadin in functional differentiations of hippocampal mossy fiber synapse,” <i>Genes to Cells</i>, vol. 22, no. 8. Wiley-Blackwell, pp. 715–722, 2017.","ama":"Geng X, Maruo T, Mandai K, et al. Roles of afadin in functional differentiations of hippocampal mossy fiber synapse. <i>Genes to Cells</i>. 2017;22(8):715-722. doi:<a href=\"https://doi.org/10.1111/gtc.12508\">10.1111/gtc.12508</a>","apa":"Geng, X., Maruo, T., Mandai, K., Supriyanto, I., Miyata, M., Sakakibara, S., … Mori, M. (2017). Roles of afadin in functional differentiations of hippocampal mossy fiber synapse. <i>Genes to Cells</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1111/gtc.12508\">https://doi.org/10.1111/gtc.12508</a>","chicago":"Geng, Xiaoqi, Tomohiko Maruo, Kenji Mandai, Irwan Supriyanto, Muneaki Miyata, Shotaro Sakakibara, Akira Mizoguchi, Yoshimi Takai, and Masahiro Mori. “Roles of Afadin in Functional Differentiations of Hippocampal Mossy Fiber Synapse.” <i>Genes to Cells</i>. Wiley-Blackwell, 2017. <a href=\"https://doi.org/10.1111/gtc.12508\">https://doi.org/10.1111/gtc.12508</a>.","ista":"Geng X, Maruo T, Mandai K, Supriyanto I, Miyata M, Sakakibara S, Mizoguchi A, Takai Y, Mori M. 2017. Roles of afadin in functional differentiations of hippocampal mossy fiber synapse. Genes to Cells. 22(8), 715–722.","short":"X. Geng, T. Maruo, K. Mandai, I. Supriyanto, M. Miyata, S. Sakakibara, A. Mizoguchi, Y. Takai, M. Mori, Genes to Cells 22 (2017) 715–722."},"date_published":"2017-08-01T00:00:00Z","publication_status":"published","abstract":[{"lang":"eng","text":"A hippocampal mossy fiber synapse has a complex structure and is implicated in learning and memory. In this synapse, the mossy fiber boutons attach to the dendritic shaft by puncta adherentia junctions and wrap around a multiply-branched spine, forming synaptic junctions. We have recently shown using transmission electron microscopy, immunoelectron microscopy and serial block face-scanning electron microscopy that atypical puncta adherentia junctions are formed in the afadin-deficient mossy fiber synapse and that the complexity of postsynaptic spines and mossy fiber boutons, the number of spine heads, the area of postsynaptic densities and the density of synaptic vesicles docked to active zones are decreased in the afadin-deficient synapse. We investigated here the roles of afadin in the functional differentiations of the mossy fiber synapse using the afadin-deficient mice. The electrophysiological studies showed that both the release probability of glutamate and the postsynaptic responsiveness to glutamate were markedly reduced, but not completely lost, in the afadin-deficient mossy fiber synapse, whereas neither long-term potentiation nor long-term depression was affected. These results indicate that afadin plays roles in the functional differentiations of the presynapse and the postsynapse of the hippocampal mossy fiber synapse."}],"department":[{"_id":"PeJo"}],"language":[{"iso":"eng"}],"_id":"706","page":"715 - 722","doi":"10.1111/gtc.12508","day":"01","author":[{"last_name":"Geng","first_name":"Xiaoqi","id":"3395256A-F248-11E8-B48F-1D18A9856A87","full_name":"Geng, Xiaoqi"},{"full_name":"Maruo, Tomohiko","first_name":"Tomohiko","last_name":"Maruo"},{"first_name":"Kenji","last_name":"Mandai","full_name":"Mandai, Kenji"},{"full_name":"Supriyanto, Irwan","last_name":"Supriyanto","first_name":"Irwan"},{"full_name":"Miyata, Muneaki","last_name":"Miyata","first_name":"Muneaki"},{"first_name":"Shotaro","last_name":"Sakakibara","full_name":"Sakakibara, Shotaro"},{"full_name":"Mizoguchi, Akira","first_name":"Akira","last_name":"Mizoguchi"},{"full_name":"Takai, Yoshimi","first_name":"Yoshimi","last_name":"Takai"},{"last_name":"Mori","first_name":"Masahiro","full_name":"Mori, Masahiro"}],"publication":"Genes to Cells","type":"journal_article","publication_identifier":{"issn":["13569597"]},"date_updated":"2021-01-12T08:11:37Z","month":"08","status":"public","title":"Roles of afadin in functional differentiations of hippocampal mossy fiber synapse","quality_controlled":"1","publist_id":"6987","date_created":"2018-12-11T11:48:02Z","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","volume":22,"oa_version":"None","intvolume":"        22","scopus_import":1,"publisher":"Wiley-Blackwell","year":"2017"}