{"intvolume":"       542","language":[{"iso":"eng"}],"main_file_link":[{"open_access":"1","url":"https://www.ncbi.nlm.nih.gov/pubmed/28099418"}],"quality_controlled":"1","title":"IL-17 is a neuromodulator of Caenorhabditis elegans sensory responses","issue":"7639","oa_version":"Submitted Version","pmid":1,"year":"2017","publisher":"Springer Nature","day":"02","date_published":"2017-02-02T00:00:00Z","date_updated":"2021-01-12T08:06:12Z","volume":542,"extern":"1","type":"journal_article","publication_identifier":{"issn":["0028-0836","1476-4687"]},"_id":"6117","doi":"10.1038/nature20818","author":[{"last_name":"Chen","first_name":"Changchun","full_name":"Chen, Changchun"},{"last_name":"Itakura","first_name":"Eisuke","full_name":"Itakura, Eisuke"},{"first_name":"Geoffrey M.","full_name":"Nelson, Geoffrey M.","last_name":"Nelson"},{"full_name":"Sheng, Ming","first_name":"Ming","last_name":"Sheng"},{"last_name":"Laurent","first_name":"Patrick","full_name":"Laurent, Patrick"},{"first_name":"Lorenz A.","full_name":"Fenk, Lorenz A.","last_name":"Fenk"},{"first_name":"Rebecca A.","full_name":"Butcher, Rebecca A.","last_name":"Butcher"},{"first_name":"Ramanujan S.","full_name":"Hegde, Ramanujan S.","last_name":"Hegde"},{"id":"4E3FF80E-F248-11E8-B48F-1D18A9856A87","last_name":"de Bono","orcid":"0000-0001-8347-0443","first_name":"Mario","full_name":"de Bono, Mario"}],"publication":"Nature","publication_status":"published","abstract":[{"text":"Interleukin-17 (IL-17) is a major pro-inflammatory cytokine: it mediates responses to pathogens or tissue damage, and drives autoimmune diseases. Little is known about its role in the nervous system. Here we show that IL-17 has neuromodulator-like properties in Caenorhabditis elegans. IL-17 can act directly on neurons to alter their response properties and contribution to behaviour. Using unbiased genetic screens, we delineate an IL-17 signalling pathway and show that it acts in the RMG hub interneurons. Disrupting IL-17 signalling reduces RMG responsiveness to input from oxygen sensors, and renders sustained escape from 21% oxygen transient and contingent on additional stimuli. Over-activating IL-17 receptors abnormally heightens responses to 21% oxygen in RMG neurons and whole animals. IL-17 deficiency can be bypassed by optogenetic stimulation of RMG. Inducing IL-17 expression in adults can rescue mutant defects within 6 h. These findings reveal a non-immunological role of IL-17 modulating circuit function and behaviour.","lang":"eng"}],"citation":{"ama":"Chen C, Itakura E, Nelson GM, et al. IL-17 is a neuromodulator of Caenorhabditis elegans sensory responses. <i>Nature</i>. 2017;542(7639):43-48. doi:<a href=\"https://doi.org/10.1038/nature20818\">10.1038/nature20818</a>","mla":"Chen, Changchun, et al. “IL-17 Is a Neuromodulator of Caenorhabditis Elegans Sensory Responses.” <i>Nature</i>, vol. 542, no. 7639, Springer Nature, 2017, pp. 43–48, doi:<a href=\"https://doi.org/10.1038/nature20818\">10.1038/nature20818</a>.","short":"C. Chen, E. Itakura, G.M. Nelson, M. Sheng, P. Laurent, L.A. Fenk, R.A. Butcher, R.S. Hegde, M. de Bono, Nature 542 (2017) 43–48.","ieee":"C. Chen <i>et al.</i>, “IL-17 is a neuromodulator of Caenorhabditis elegans sensory responses,” <i>Nature</i>, vol. 542, no. 7639. Springer Nature, pp. 43–48, 2017.","chicago":"Chen, Changchun, Eisuke Itakura, Geoffrey M. Nelson, Ming Sheng, Patrick Laurent, Lorenz A. Fenk, Rebecca A. Butcher, Ramanujan S. Hegde, and Mario de Bono. “IL-17 Is a Neuromodulator of Caenorhabditis Elegans Sensory Responses.” <i>Nature</i>. Springer Nature, 2017. <a href=\"https://doi.org/10.1038/nature20818\">https://doi.org/10.1038/nature20818</a>.","ista":"Chen C, Itakura E, Nelson GM, Sheng M, Laurent P, Fenk LA, Butcher RA, Hegde RS, de Bono M. 2017. IL-17 is a neuromodulator of Caenorhabditis elegans sensory responses. Nature. 542(7639), 43–48.","apa":"Chen, C., Itakura, E., Nelson, G. M., Sheng, M., Laurent, P., Fenk, L. A., … de Bono, M. (2017). IL-17 is a neuromodulator of Caenorhabditis elegans sensory responses. <i>Nature</i>. Springer Nature. <a href=\"https://doi.org/10.1038/nature20818\">https://doi.org/10.1038/nature20818</a>"},"month":"02","date_created":"2019-03-19T14:06:41Z","status":"public","page":"43-48","external_id":{"pmid":["    28099418"]},"user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","oa":1}