{"day":"01","license":"https://creativecommons.org/licenses/by/4.0/","type":"journal_article","file":[{"checksum":"2123845e7031a0cf043905be160f9e69","relation":"main_file","content_type":"application/pdf","access_level":"open_access","creator":"system","file_name":"IST-2018-1058-v1+1_365.full__1_.pdf","date_updated":"2020-07-14T12:46:50Z","file_id":"5132","file_size":1311661,"date_created":"2018-12-12T10:15:14Z"}],"date_updated":"2024-02-21T13:48:27Z","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"month":"01","article_processing_charge":"No","issue":"1","date_published":"2018-01-01T00:00:00Z","publication_status":"published","abstract":[{"text":"The t-haplotype, a mouse meiotic driver found on chromosome 17, has been a model for autosomal segregation distortion for close to a century, but several questions remain regarding its biology and evolutionary history. A recently published set of population genomics resources for wild mice includes several individuals heterozygous for the t-haplotype, which we use to characterize this selfish element at the genomic and transcriptomic level. Our results show that large sections of the t-haplotype have been replaced by standard homologous sequences, possibly due to occasional events of recombination, and that this complicates the inference of its history. As expected for a long genomic segment of very low recombination, the t-haplotype carries an excess of fixed nonsynonymous mutations compared to the standard chromosome. This excess is stronger for regions that have not undergone recent recombination, suggesting that occasional gene flow between the t and the standard chromosome may provide a mechanism to regenerate coding sequences that have accumulated deleterious mutations. Finally, we find that t-complex genes with altered expression largely overlap with deleted or amplified regions, and that carrying a t-haplotype alters the testis expression of genes outside of the t-complex, providing new leads into the pathways involved in the biology of this segregation distorter.","lang":"eng"}],"department":[{"_id":"BeVi"}],"date_created":"2018-12-11T11:47:04Z","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","oa_version":"Published Version","oa":1,"scopus_import":"1","publisher":"Genetics Society of America","status":"public","related_material":{"record":[{"status":"public","id":"5571","relation":"popular_science"},{"status":"public","id":"5572","relation":"popular_science"}]},"title":"Complex history and differentiation patterns of the t-haplotype, a mouse meiotic driver","quality_controlled":"1","has_accepted_license":"1","publication":"Genetics","author":[{"last_name":"Kelemen","first_name":"Réka K","full_name":"Kelemen, Réka K","id":"48D3F8DE-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8489-9281"},{"id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87","full_name":"Vicoso, Beatriz","first_name":"Beatriz","last_name":"Vicoso","orcid":"0000-0002-4579-8306"}],"doi":"10.1534/genetics.117.300513","page":"365 - 375","external_id":{"isi":["000419356300024"]},"article_type":"original","citation":{"mla":"Kelemen, Réka K., and Beatriz Vicoso. “Complex History and Differentiation Patterns of the T-Haplotype, a Mouse Meiotic Driver.” <i>Genetics</i>, vol. 208, no. 1, Genetics Society of America, 2018, pp. 365–75, doi:<a href=\"https://doi.org/10.1534/genetics.117.300513\">10.1534/genetics.117.300513</a>.","ieee":"R. K. Kelemen and B. Vicoso, “Complex history and differentiation patterns of the t-haplotype, a mouse meiotic driver,” <i>Genetics</i>, vol. 208, no. 1. Genetics Society of America, pp. 365–375, 2018.","apa":"Kelemen, R. K., &#38; Vicoso, B. (2018). Complex history and differentiation patterns of the t-haplotype, a mouse meiotic driver. <i>Genetics</i>. Genetics Society of America. <a href=\"https://doi.org/10.1534/genetics.117.300513\">https://doi.org/10.1534/genetics.117.300513</a>","chicago":"Kelemen, Réka K, and Beatriz Vicoso. “Complex History and Differentiation Patterns of the T-Haplotype, a Mouse Meiotic Driver.” <i>Genetics</i>. Genetics Society of America, 2018. <a href=\"https://doi.org/10.1534/genetics.117.300513\">https://doi.org/10.1534/genetics.117.300513</a>.","ista":"Kelemen RK, Vicoso B. 2018. Complex history and differentiation patterns of the t-haplotype, a mouse meiotic driver. Genetics. 208(1), 365–375.","ama":"Kelemen RK, Vicoso B. Complex history and differentiation patterns of the t-haplotype, a mouse meiotic driver. <i>Genetics</i>. 2018;208(1):365-375. doi:<a href=\"https://doi.org/10.1534/genetics.117.300513\">10.1534/genetics.117.300513</a>","short":"R.K. Kelemen, B. Vicoso, Genetics 208 (2018) 365–375."},"ec_funded":1,"_id":"542","language":[{"iso":"eng"}],"pubrep_id":"1058","volume":208,"publist_id":"7274","intvolume":"       208","year":"2018","file_date_updated":"2020-07-14T12:46:50Z","isi":1,"project":[{"_id":"250BDE62-B435-11E9-9278-68D0E5697425","name":"Prevalence and Influence of Sexual Antagonism on Genome Evolution","grant_number":"715257","call_identifier":"H2020"}],"ddc":["576"]}