{"date_created":"2018-12-11T12:08:10Z","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","oa_version":"None","publisher":"Wiley-Blackwell","status":"public","quality_controlled":"1","title":"A comparison of three methods for estimating average levels of gene flow","day":"01","type":"journal_article","date_updated":"2022-02-10T09:44:53Z","pmid":1,"month":"11","article_processing_charge":"No","issue":"7","date_published":"1989-11-01T00:00:00Z","extern":"1","publication_status":"published","abstract":[{"lang":"eng","text":"Three methods for estimating the average level of gene flow in natural population are discussed and compared. The three methods are FST, rare alleles, and maximum likelihood. All three methods yield estimates of the combination of parameters (the number of migrants [Nm] in a demic model or the neighborhood size [4πDσ2] in a continuum model) that determines the relative importance of gene flow and genetic drift. We review the theory underlying these methods and derive new analytic results for the expectation of FST in stepping-stone and continuum models when small sets of samples are taken. We also compare the effectiveness of the different methods using a variety of simulated data. We found that the FST and rare-alleles methods yield comparable estimates under a wide variety of conditions when the population being sampled is demographically stable. They are roughly equally sensitive to selection and to variation in population structure, and they approach their equilibrium values at approximately the same rate. We found that two different maximum-likelihood methods tend to yield biased estimates when relatively small numbers of locations are sampled but more accurate estimates when larger numbers are sampled. Our conclusion is that, although FST and rare-alleles methods are expected to be equally effective in analyzing ideal data, practical problems in estimating the frequencies of rare alleles in electrophoretic studies suggest that FST is likely to be more useful under realistic conditions."}],"main_file_link":[{"url":"http://www.jstor.org/stable/2409452"}],"publist_id":"1751","volume":43,"intvolume":"        43","year":"1989","acknowledgement":"This research has been supported in partv by grant 85-00258 from the National Science Foundation and by grants GR/C/9 1529 and GR/E/08507 from the Science and Engineering Research Council. We thank C. C. Cockerham and B. S. Weir for helpful discussions of this topic, C. Wehrhahn for bringing his method to our attention and for providing us with a copy of his program for estimating Nm, and J. Coyne, M. Nei, B. S. Weir, and an anonymous referee for comments on an earlier draft of this paper.","publication":"Evolution; International Journal of Organic Evolution","author":[{"last_name":"Slatkin","first_name":"Montgomery","full_name":"Slatkin, Montgomery"},{"full_name":"Barton, Nicholas H","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","first_name":"Nicholas H","last_name":"Barton","orcid":"0000-0002-8548-5240"}],"doi":"10.1111/j.1558-5646.1989.tb02587.x ","page":"1349 - 1368","publication_identifier":{"issn":["0014-3820"],"eissn":["1558-5646"]},"external_id":{"pmid":["28564250 "]},"article_type":"original","citation":{"ieee":"M. Slatkin and N. H. Barton, “A comparison of three methods for estimating average levels of gene flow,” <i>Evolution; International Journal of Organic Evolution</i>, vol. 43, no. 7. Wiley-Blackwell, pp. 1349–1368, 1989.","mla":"Slatkin, Montgomery, and Nicholas H. Barton. “A Comparison of Three Methods for Estimating Average Levels of Gene Flow.” <i>Evolution; International Journal of Organic Evolution</i>, vol. 43, no. 7, Wiley-Blackwell, 1989, pp. 1349–68, doi:<a href=\"https://doi.org/10.1111/j.1558-5646.1989.tb02587.x \">10.1111/j.1558-5646.1989.tb02587.x </a>.","short":"M. Slatkin, N.H. Barton, Evolution; International Journal of Organic Evolution 43 (1989) 1349–1368.","apa":"Slatkin, M., &#38; Barton, N. H. (1989). A comparison of three methods for estimating average levels of gene flow. <i>Evolution; International Journal of Organic Evolution</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1111/j.1558-5646.1989.tb02587.x \">https://doi.org/10.1111/j.1558-5646.1989.tb02587.x </a>","chicago":"Slatkin, Montgomery, and Nicholas H Barton. “A Comparison of Three Methods for Estimating Average Levels of Gene Flow.” <i>Evolution; International Journal of Organic Evolution</i>. Wiley-Blackwell, 1989. <a href=\"https://doi.org/10.1111/j.1558-5646.1989.tb02587.x \">https://doi.org/10.1111/j.1558-5646.1989.tb02587.x </a>.","ista":"Slatkin M, Barton NH. 1989. A comparison of three methods for estimating average levels of gene flow. Evolution; International Journal of Organic Evolution. 43(7), 1349–1368.","ama":"Slatkin M, Barton NH. A comparison of three methods for estimating average levels of gene flow. <i>Evolution; International Journal of Organic Evolution</i>. 1989;43(7):1349-1368. doi:<a href=\"https://doi.org/10.1111/j.1558-5646.1989.tb02587.x \">10.1111/j.1558-5646.1989.tb02587.x </a>"},"_id":"4309","language":[{"iso":"eng"}]}