{"publisher":"Royal Society, The","year":"2005","oa":1,"intvolume":"       360","date_created":"2018-12-11T12:07:51Z","volume":360,"publist_id":"1847","quality_controlled":0,"title":"Theoretical models of selection and mutationon quantitative traits","status":"public","month":"07","date_updated":"2021-01-12T07:55:38Z","type":"journal_article","doi":"10.1098/rstb.2005.1667","page":"1411 - 1425","day":"29","publication":"Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences","author":[{"full_name":"Johnson, Toby","first_name":"Toby","last_name":"Johnson"},{"id":"4880FE40-F248-11E8-B48F-1D18A9856A87","full_name":"Nicholas Barton","last_name":"Barton","first_name":"Nicholas H","orcid":"0000-0002-8548-5240"}],"_id":"4252","abstract":[{"lang":"eng","text":"Empirical studies of quantitative genetic variation have revealed robust patterns that are observed both across traits and across species. However, these patterns have no compelling explanation, and some of the observations even appear to be mutually incompatible. We review and extend a major class of theoretical models, ‘mutation–selection models’, that have been proposed to explain quantitative genetic variation. We also briefly review an alternative class of ‘balancing selection models’. We consider to what extent the models are compatible with the general observations, and argue that a key issue is understanding and modelling pleiotropy. We discuss some"}],"main_file_link":[{"url":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1569515/","open_access":"1"}],"extern":1,"publication_status":"published","date_published":"2005-07-29T00:00:00Z","citation":{"short":"T. Johnson, N.H. Barton, Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 360 (2005) 1411–1425.","ama":"Johnson T, Barton NH. Theoretical models of selection and mutationon quantitative traits. <i>Philosophical Transactions of the Royal Society of London Series B, Biological Sciences</i>. 2005;360(1459):1411-1425. doi:<a href=\"https://doi.org/10.1098/rstb.2005.1667\">10.1098/rstb.2005.1667</a>","ista":"Johnson T, Barton NH. 2005. Theoretical models of selection and mutationon quantitative traits. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 360(1459), 1411–1425.","apa":"Johnson, T., &#38; Barton, N. H. (2005). Theoretical models of selection and mutationon quantitative traits. <i>Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences</i>. Royal Society, The. <a href=\"https://doi.org/10.1098/rstb.2005.1667\">https://doi.org/10.1098/rstb.2005.1667</a>","chicago":"Johnson, Toby, and Nicholas H Barton. “Theoretical Models of Selection and Mutationon Quantitative Traits.” <i>Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences</i>. Royal Society, The, 2005. <a href=\"https://doi.org/10.1098/rstb.2005.1667\">https://doi.org/10.1098/rstb.2005.1667</a>.","ieee":"T. Johnson and N. H. Barton, “Theoretical models of selection and mutationon quantitative traits,” <i>Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences</i>, vol. 360, no. 1459. Royal Society, The, pp. 1411–1425, 2005.","mla":"Johnson, Toby, and Nicholas H. Barton. “Theoretical Models of Selection and Mutationon Quantitative Traits.” <i>Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences</i>, vol. 360, no. 1459, Royal Society, The, 2005, pp. 1411–25, doi:<a href=\"https://doi.org/10.1098/rstb.2005.1667\">10.1098/rstb.2005.1667</a>."},"issue":"1459"}