{"oa_version":"None","intvolume":"        17","date_created":"2018-12-11T12:07:42Z","volume":17,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publist_id":"1891","year":"2007","publisher":"Cold Spring Harbor Laboratory Press","title":"Evolution and multilevel optimization of the genetic code","status":"public","type":"journal_article","publication":"Genome Research","day":"09","author":[{"orcid":"0000-0003-4398-476X","first_name":"Mark Tobias","last_name":"Bollenbach","full_name":"Bollenbach, Mark Tobias","id":"3E6DB97A-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Vetsigian, Kalin","last_name":"Vetsigian","first_name":"Kalin"},{"last_name":"Kishony","first_name":"Roy","full_name":"Kishony, Roy"}],"page":"401 - 404","doi":"10.1101/gr.6144007","article_processing_charge":"No","month":"03","date_updated":"2021-01-12T07:55:26Z","publication_status":"published","extern":"1","citation":{"ieee":"M. T. Bollenbach, K. Vetsigian, and R. Kishony, “Evolution and multilevel optimization of the genetic code,” <i>Genome Research</i>, vol. 17, no. 4. Cold Spring Harbor Laboratory Press, pp. 401–404, 2007.","mla":"Bollenbach, Mark Tobias, et al. “Evolution and Multilevel Optimization of the Genetic Code.” <i>Genome Research</i>, vol. 17, no. 4, Cold Spring Harbor Laboratory Press, 2007, pp. 401–04, doi:<a href=\"https://doi.org/10.1101/gr.6144007\">10.1101/gr.6144007</a>.","short":"M.T. Bollenbach, K. Vetsigian, R. Kishony, Genome Research 17 (2007) 401–404.","chicago":"Bollenbach, Mark Tobias, Kalin Vetsigian, and Roy Kishony. “Evolution and Multilevel Optimization of the Genetic Code.” <i>Genome Research</i>. Cold Spring Harbor Laboratory Press, 2007. <a href=\"https://doi.org/10.1101/gr.6144007\">https://doi.org/10.1101/gr.6144007</a>.","ista":"Bollenbach MT, Vetsigian K, Kishony R. 2007. Evolution and multilevel optimization of the genetic code. Genome Research. 17(4), 401–404.","apa":"Bollenbach, M. T., Vetsigian, K., &#38; Kishony, R. (2007). Evolution and multilevel optimization of the genetic code. <i>Genome Research</i>. Cold Spring Harbor Laboratory Press. <a href=\"https://doi.org/10.1101/gr.6144007\">https://doi.org/10.1101/gr.6144007</a>","ama":"Bollenbach MT, Vetsigian K, Kishony R. Evolution and multilevel optimization of the genetic code. <i>Genome Research</i>. 2007;17(4):401-404. doi:<a href=\"https://doi.org/10.1101/gr.6144007\">10.1101/gr.6144007</a>"},"date_published":"2007-03-09T00:00:00Z","issue":"4","_id":"4225","language":[{"iso":"eng"}],"abstract":[{"text":"The discovery of the genetic code was one of the most important advances of modern biology. But there is more to a DNA code than protein sequence; DNA carries signals for splicing, localization, folding, and regulation that are often embedded within the protein-coding sequence. In this issue, Itzkovitz and Alon show that the specific 64-to-20 mapping found in the genetic code may have been optimized for permitting protein-coding regions to carry this extra information and suggest that this property may have evolved as a side benefit of selection to minimize the negative effects of frameshift errors.","lang":"eng"}]}