{"quality_controlled":"1","scopus_import":"1","title":"Planar cell polarization requires Widerborst, a B′ regulatory subunit of protein phosphatase 2A","oa_version":"None","issue":"14","publist_id":"1909","language":[{"iso":"eng"}],"intvolume":"       129","day":"15","article_type":"original","year":"2002","publisher":"Company of Biologists","date_published":"2002-07-15T00:00:00Z","pmid":1,"_id":"4209","author":[{"last_name":"Hannus","first_name":"Michael","full_name":"Hannus, Michael"},{"first_name":"Fabian","full_name":"Feiguin, Fabian","last_name":"Feiguin"},{"last_name":"Heisenberg","id":"39427864-F248-11E8-B48F-1D18A9856A87","first_name":"Carl-Philipp J","full_name":"Heisenberg, Carl-Philipp J","orcid":"0000-0002-0912-4566"},{"last_name":"Eaton","first_name":"Suzanne","full_name":"Eaton, Suzanne"}],"doi":"10.1242/dev.129.14.3493","abstract":[{"text":"We have identified widerborst (wdb), a B' regulatory subunit of PP2A, as a conserved component of planar cell polarization mechanisms in both Drosophila and in zebrafish. In Drosophila, wdb acts at two steps during planar polarization of wing epithelial cells. It is required to organize tissue polarity proteins into proximal and distal cortical domains, thus determining wing hair orientation. It is also needed to generate the polarized membrane outgrowth that becomes the wing hair. Widerborst activates the catalytic subunit of PP2A and localizes to the distal side of a planar microtubule web that lies at the level of apical cell junctions. This suggests that polarized PP2A activation along the planar microtubule web is important for planar polarization. In zebrafish, two wdb homologs are required for convergent extension during gastrulation, supporting the conjecture that Drosophila planar cell polarization and vertebrate gastrulation movements are regulated by similar mechanisms.","lang":"eng"}],"publication_status":"published","publication":"Development","extern":"1","type":"journal_article","date_updated":"2023-06-06T14:07:49Z","volume":129,"publication_identifier":{"issn":["0950-1991"]},"external_id":{"pmid":["12091318"]},"status":"public","page":"3493 - 3503","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","acknowledgement":"We gratefully acknowledge Bianca Habermann for assistance with bioinformatics, Jens Rietdorf and Arshad Desai for help with deconvolution, and Tadashi Uemura and Rick Fehon for providing antibodies. Arshad Desai, Christian Dahmann, Tony Hyman and Elly Tanaka provided helpful comments on the manuscript. Part of this work was performed at the EMBL in Heidelberg.","article_processing_charge":"No","month":"07","date_created":"2018-12-11T12:07:36Z","citation":{"ieee":"M. Hannus, F. Feiguin, C.-P. J. Heisenberg, and S. Eaton, “Planar cell polarization requires Widerborst, a B′ regulatory subunit of protein phosphatase 2A,” <i>Development</i>, vol. 129, no. 14. Company of Biologists, pp. 3493–3503, 2002.","ama":"Hannus M, Feiguin F, Heisenberg C-PJ, Eaton S. Planar cell polarization requires Widerborst, a B′ regulatory subunit of protein phosphatase 2A. <i>Development</i>. 2002;129(14):3493-3503. doi:<a href=\"https://doi.org/10.1242/dev.129.14.3493\">10.1242/dev.129.14.3493</a>","mla":"Hannus, Michael, et al. “Planar Cell Polarization Requires Widerborst, a B′ Regulatory Subunit of Protein Phosphatase 2A.” <i>Development</i>, vol. 129, no. 14, Company of Biologists, 2002, pp. 3493–503, doi:<a href=\"https://doi.org/10.1242/dev.129.14.3493\">10.1242/dev.129.14.3493</a>.","short":"M. Hannus, F. Feiguin, C.-P.J. Heisenberg, S. Eaton, Development 129 (2002) 3493–3503.","apa":"Hannus, M., Feiguin, F., Heisenberg, C.-P. J., &#38; Eaton, S. (2002). Planar cell polarization requires Widerborst, a B′ regulatory subunit of protein phosphatase 2A. <i>Development</i>. Company of Biologists. <a href=\"https://doi.org/10.1242/dev.129.14.3493\">https://doi.org/10.1242/dev.129.14.3493</a>","ista":"Hannus M, Feiguin F, Heisenberg C-PJ, Eaton S. 2002. Planar cell polarization requires Widerborst, a B′ regulatory subunit of protein phosphatase 2A. Development. 129(14), 3493–3503.","chicago":"Hannus, Michael, Fabian Feiguin, Carl-Philipp J Heisenberg, and Suzanne Eaton. “Planar Cell Polarization Requires Widerborst, a B′ Regulatory Subunit of Protein Phosphatase 2A.” <i>Development</i>. Company of Biologists, 2002. <a href=\"https://doi.org/10.1242/dev.129.14.3493\">https://doi.org/10.1242/dev.129.14.3493</a>."}}