{"publication_identifier":{"issn":["0950-1991"]},"volume":123,"date_updated":"2022-08-05T08:06:15Z","type":"journal_article","extern":"1","publication_status":"published","publication":"Development","abstract":[{"lang":"eng","text":"We identified four zebrafish mutants with defects in forebrain induction and patterning during embryogenesis. The four mutants define three genes: masterblind (mbl), silverblick (slb), and knollnase (kas), In mbl embryos, the anterior forebrain acquires posterior forebrain characteristics: anterior structures such as the eyes, olfactory placodes and the telencephalon are missing, whereas the epiphysis located in the posterior forebrain is expanded, In slb embryos, the extension of the embryonic axis is initially delayed and eventually followed by a partial fusion of the eyes, Finally, in kas embryos, separation of the telencephalic primordia is incomplete and dorsal midline cells fail to form a differentiated roof plate, Analysis of the mutant phenotypes indicates that we have identified genes essential for the specification of the anterior forebrain (mbl), positioning of the eyes (slb) and differentiation of the roof plate (kas). In an appendix to this study we list mutants showing alterations in the size of the eyes and abnormal differentiation of the lenses."}],"author":[{"last_name":"Heisenberg","id":"39427864-F248-11E8-B48F-1D18A9856A87","first_name":"Carl-Philipp J","full_name":"Heisenberg, Carl-Philipp J","orcid":"0000-0002-0912-4566"},{"full_name":"Brand, Michael","first_name":"Michael","last_name":"Brand"},{"last_name":"Jiang","full_name":"Jiang, Yunjin","first_name":"Yunjin"},{"last_name":"Warga","first_name":"Rachel","full_name":"Warga, Rachel"},{"last_name":"Beuchle","first_name":"Dirk","full_name":"Beuchle, Dirk"},{"last_name":"Van Eeden","first_name":"Fredericus","full_name":"Van Eeden, Fredericus"},{"last_name":"Furutani Seiki","full_name":"Furutani Seiki, Makoto","first_name":"Makoto"},{"full_name":"Granato, Michael","first_name":"Michael","last_name":"Granato"},{"last_name":"Haffter","first_name":"Pascal","full_name":"Haffter, Pascal"},{"last_name":"Hammerschmidt","first_name":"Matthias","full_name":"Hammerschmidt, Matthias"},{"last_name":"Kane","first_name":"Donald","full_name":"Kane, Donald"},{"last_name":"Kelsh","first_name":"Robert","full_name":"Kelsh, Robert"},{"last_name":"Mullins","full_name":"Mullins, Mary","first_name":"Mary"},{"last_name":"Odenthal","full_name":"Odenthal, Jörg","first_name":"Jörg"},{"last_name":"Nüsslein Volhard","full_name":"Nüsslein Volhard, Christiane","first_name":"Christiane"}],"doi":"10.1242/dev.123.1.191 ","_id":"4203","citation":{"ista":"Heisenberg C-PJ, Brand M, Jiang Y, Warga R, Beuchle D, Van Eeden F, Furutani Seiki M, Granato M, Haffter P, Hammerschmidt M, Kane D, Kelsh R, Mullins M, Odenthal J, Nüsslein Volhard C. 1996. Genes involved in forebrain development in the zebrafish, Danio rerio. Development. 123, 191–203.","chicago":"Heisenberg, Carl-Philipp J, Michael Brand, Yunjin Jiang, Rachel Warga, Dirk Beuchle, Fredericus Van Eeden, Makoto Furutani Seiki, et al. “Genes Involved in Forebrain Development in the Zebrafish, Danio Rerio.” <i>Development</i>. Company of Biologists, 1996. <a href=\"https://doi.org/10.1242/dev.123.1.191 \">https://doi.org/10.1242/dev.123.1.191 </a>.","apa":"Heisenberg, C.-P. J., Brand, M., Jiang, Y., Warga, R., Beuchle, D., Van Eeden, F., … Nüsslein Volhard, C. (1996). Genes involved in forebrain development in the zebrafish, Danio rerio. <i>Development</i>. Company of Biologists. <a href=\"https://doi.org/10.1242/dev.123.1.191 \">https://doi.org/10.1242/dev.123.1.191 </a>","short":"C.-P.J. Heisenberg, M. Brand, Y. Jiang, R. Warga, D. Beuchle, F. Van Eeden, M. Furutani Seiki, M. Granato, P. Haffter, M. Hammerschmidt, D. Kane, R. Kelsh, M. Mullins, J. Odenthal, C. Nüsslein Volhard, Development 123 (1996) 191–203.","ama":"Heisenberg C-PJ, Brand M, Jiang Y, et al. Genes involved in forebrain development in the zebrafish, Danio rerio. <i>Development</i>. 1996;123:191-203. doi:<a href=\"https://doi.org/10.1242/dev.123.1.191 \">10.1242/dev.123.1.191 </a>","mla":"Heisenberg, Carl-Philipp J., et al. “Genes Involved in Forebrain Development in the Zebrafish, Danio Rerio.” <i>Development</i>, vol. 123, Company of Biologists, 1996, pp. 191–203, doi:<a href=\"https://doi.org/10.1242/dev.123.1.191 \">10.1242/dev.123.1.191 </a>.","ieee":"C.-P. J. Heisenberg <i>et al.</i>, “Genes involved in forebrain development in the zebrafish, Danio rerio,” <i>Development</i>, vol. 123. Company of Biologists, pp. 191–203, 1996."},"date_created":"2018-12-11T12:07:34Z","month":"12","article_processing_charge":"No","acknowledgement":"We thank E. Weinberg for the kind gift of myoD, zotx-2 and zash1b cDNA, I. Mikkola and S. Krauss for providing pax2/6 antibodies and shh cDNA, and V. Korzh for providing the pan-islet antibody. We are grateful to S. Wilson for help with the initial characterization of the mbl phenotype and many valuable comments on the manuscript. We would also like to thank Robert Geisler, Suresh Jesuthasan, Rolf Karlstrom, Stefan Schulte-Merker and Siegfried Roth for critical reading of the manuscript.","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","page":"191 - 203","status":"public","external_id":{"pmid":["9007240 "]},"intvolume":"       123","language":[{"iso":"eng"}],"publist_id":"1913","oa_version":"None","title":"Genes involved in forebrain development in the zebrafish, Danio rerio","scopus_import":"1","quality_controlled":"1","pmid":1,"date_published":"1996-12-01T00:00:00Z","publisher":"Company of Biologists","year":"1996","article_type":"original","day":"01"}