{"author":[{"first_name":"Donald","full_name":"Kane, Donald","last_name":"Kane"},{"last_name":"Hammerschmidt","full_name":"Hammerschmidt, Matthias","first_name":"Matthias"},{"last_name":"Mullins","first_name":"Mary","full_name":"Mullins, Mary"},{"full_name":"Maischein, Hans","first_name":"Hans","last_name":"Maischein"},{"last_name":"Brand","full_name":"Brand, Michael","first_name":"Michael"},{"last_name":"Van Eeden","full_name":"Van Eeden, Fredericus","first_name":"Fredericus"},{"last_name":"Furutani Seiki","full_name":"Furutani Seiki, Makoto","first_name":"Makoto"},{"last_name":"Granato","first_name":"Michael","full_name":"Granato, Michael"},{"full_name":"Haffter, Pascal","first_name":"Pascal","last_name":"Haffter"},{"id":"39427864-F248-11E8-B48F-1D18A9856A87","last_name":"Heisenberg","orcid":"0000-0002-0912-4566","first_name":"Carl-Philipp J","full_name":"Heisenberg, Carl-Philipp J"},{"last_name":"Jiang","first_name":"Yunjin","full_name":"Jiang, Yunjin"},{"last_name":"Kelsh","full_name":"Kelsh, Robert","first_name":"Robert"},{"first_name":"Jörg","full_name":"Odenthal, Jörg","last_name":"Odenthal"},{"last_name":"Warga","first_name":"Rachel","full_name":"Warga, Rachel"},{"last_name":"Nüsslein Volhard","full_name":"Nüsslein Volhard, Christiane","first_name":"Christiane"}],"doi":"10.1242/dev.123.1.47 ","_id":"4188","publication_status":"published","publication":"Development","abstract":[{"text":"Epiboly, the enveloping of the yolk cell by the blastoderm, is the first zebrafish morphogenetic movement, We isolated four mutations that affect epiboly: half baked, avalanche, lawine and weg, Homozygous mutant embryos arrest the vegetal progress of the deep cells of the blastoderm; only the yolk syncytial layer of the yolk cell and the enveloping layer of the blastoderm reach the vegetal pole of the embryo, The mutations half baked, avalanche and lawine produce a novel dominant effect, termed a zygotic-maternal dominant effect: heterozygous embryos produced from heterozygous females slow down epiboly and accumulate detached cells over the neural tube; a small fraction of these mutant individuals are viable, Heterozygous embryos produced from heterozygous males crossed to homozygous wild-type females complete epiboly normally and are completely viable. Additionally, embryos heterozygous for half baked have an enlarged hatching gland, a partial dominant phenotype, The phenotypes of these mutants demonstrate that, for the spreading of cells during epiboly, the movement of the deep cells of the blastoderm require the function of genes that are not necessary for the movement of the enveloping layer or the yolk cell, Furthermore, the dominant zygotic-maternal effect phenotypes illustrate the maternal and zygotic interplay of genes that orchestrate the early cell movements of the zebrafish.","lang":"eng"}],"volume":123,"date_updated":"2022-08-05T09:22:40Z","type":"journal_article","extern":"1","publication_identifier":{"issn":["0950-1991"]},"page":"47 - 55","status":"public","external_id":{"pmid":["9007228 "]},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","article_processing_charge":"No","acknowledgement":"We thank Drs John Postlethwait and Sigfreid Roth for their helpful comments on earlier drafts of this paper. This work was supported in part by a grant from the National Institutes of Health to D. A. K.","citation":{"apa":"Kane, D., Hammerschmidt, M., Mullins, M., Maischein, H., Brand, M., Van Eeden, F., … Nüsslein Volhard, C. (1996). The zebrafish epiboly mutants. <i>Development</i>. Company of Biologists. <a href=\"https://doi.org/10.1242/dev.123.1.47 \">https://doi.org/10.1242/dev.123.1.47 </a>","chicago":"Kane, Donald, Matthias Hammerschmidt, Mary Mullins, Hans Maischein, Michael Brand, Fredericus Van Eeden, Makoto Furutani Seiki, et al. “The Zebrafish Epiboly Mutants.” <i>Development</i>. Company of Biologists, 1996. <a href=\"https://doi.org/10.1242/dev.123.1.47 \">https://doi.org/10.1242/dev.123.1.47 </a>.","ista":"Kane D, Hammerschmidt M, Mullins M, Maischein H, Brand M, Van Eeden F, Furutani Seiki M, Granato M, Haffter P, Heisenberg C-PJ, Jiang Y, Kelsh R, Odenthal J, Warga R, Nüsslein Volhard C. 1996. The zebrafish epiboly mutants. Development. 123(1), 47–55.","ieee":"D. Kane <i>et al.</i>, “The zebrafish epiboly mutants,” <i>Development</i>, vol. 123, no. 1. Company of Biologists, pp. 47–55, 1996.","mla":"Kane, Donald, et al. “The Zebrafish Epiboly Mutants.” <i>Development</i>, vol. 123, no. 1, Company of Biologists, 1996, pp. 47–55, doi:<a href=\"https://doi.org/10.1242/dev.123.1.47 \">10.1242/dev.123.1.47 </a>.","ama":"Kane D, Hammerschmidt M, Mullins M, et al. The zebrafish epiboly mutants. <i>Development</i>. 1996;123(1):47-55. doi:<a href=\"https://doi.org/10.1242/dev.123.1.47 \">10.1242/dev.123.1.47 </a>","short":"D. Kane, M. Hammerschmidt, M. Mullins, H. Maischein, M. Brand, F. Van Eeden, M. Furutani Seiki, M. Granato, P. Haffter, C.-P.J. Heisenberg, Y. Jiang, R. Kelsh, J. Odenthal, R. Warga, C. Nüsslein Volhard, Development 123 (1996) 47–55."},"date_created":"2018-12-11T12:07:29Z","month":"12","title":"The zebrafish epiboly mutants","scopus_import":"1","quality_controlled":"1","issue":"1","oa_version":"None","publist_id":"1930","intvolume":"       123","language":[{"iso":"eng"}],"article_type":"original","year":"1996","publisher":"Company of Biologists","day":"01","date_published":"1996-12-01T00:00:00Z","pmid":1}