{"publication":"Journal of Biological Chemistry","publication_status":"published","abstract":[{"lang":"eng","text":"Neurotrophin-3 (NT-3) is a member of the neurotrophin gene family and is highly expressed in the developing rat cerebellum. Here we show that brain-derived neurotrophic factor (BDNF) increased by approximately 10-fold the NT-3 mRNA levels in cultured cerebellar granule neurons isolated from postnatal rats, whereas nerve growth factor (NGF) and NT-3 itself had no effect. The effect of BDNF was additive to that of triiodothyronine (T3), which also increased NT-3 mRNA in these neurons. The drug K252a inhibited the BDNF-mediated stimulation of NT-3 expression, suggesting an involvement of trkB receptors. Nuclear run-on experiments showed that BDNF enhanced NT-3 transcription, whereas the stability of NT-3 mRNA remained unchanged. The data presented are the first demonstration that one neurotrophin regulates the expression of another and provide evidence that NT-3 production in granule neurons is regulated by both BDNF and T3."}],"_id":"4179","doi":"10.1016/s0021-9258(17)42186-7","author":[{"last_name":"Leingärtner","first_name":"Axel","full_name":"Leingärtner, Axel"},{"id":"39427864-F248-11E8-B48F-1D18A9856A87","last_name":"Heisenberg","orcid":"0000-0002-0912-4566","full_name":"Heisenberg, Carl-Philipp J","first_name":"Carl-Philipp J"},{"last_name":"Kolbeck","first_name":"Roland","full_name":"Kolbeck, Roland"},{"last_name":"Thoenen","first_name":"Hans","full_name":"Thoenen, Hans"},{"full_name":"Lindholm, Dan","first_name":"Dan","last_name":"Lindholm"}],"publication_identifier":{"eissn":["1083-351X"],"issn":["0021-9258"]},"date_updated":"2022-06-02T10:23:48Z","volume":269,"extern":"1","type":"journal_article","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","oa":1,"status":"public","page":"828 - 830","citation":{"mla":"Leingärtner, Axel, et al. “Brain-Derived Neurotrophic Factor Increases Neurotrophin-3 Expression in Cerebellar Granule Neurons.” <i>Journal of Biological Chemistry</i>, vol. 269, no. 2, American Society for Biochemistry and Molecular Biology, 1994, pp. 828–30, doi:<a href=\"https://doi.org/10.1016/s0021-9258(17)42186-7\">10.1016/s0021-9258(17)42186-7</a>.","ama":"Leingärtner A, Heisenberg C-PJ, Kolbeck R, Thoenen H, Lindholm D. Brain-derived neurotrophic factor increases neurotrophin-3 expression in cerebellar granule neurons. <i>Journal of Biological Chemistry</i>. 1994;269(2):828-830. doi:<a href=\"https://doi.org/10.1016/s0021-9258(17)42186-7\">10.1016/s0021-9258(17)42186-7</a>","short":"A. Leingärtner, C.-P.J. Heisenberg, R. Kolbeck, H. Thoenen, D. Lindholm, Journal of Biological Chemistry 269 (1994) 828–830.","ieee":"A. Leingärtner, C.-P. J. Heisenberg, R. Kolbeck, H. Thoenen, and D. Lindholm, “Brain-derived neurotrophic factor increases neurotrophin-3 expression in cerebellar granule neurons,” <i>Journal of Biological Chemistry</i>, vol. 269, no. 2. American Society for Biochemistry and Molecular Biology, pp. 828–830, 1994.","ista":"Leingärtner A, Heisenberg C-PJ, Kolbeck R, Thoenen H, Lindholm D. 1994. Brain-derived neurotrophic factor increases neurotrophin-3 expression in cerebellar granule neurons. Journal of Biological Chemistry. 269(2), 828–830.","chicago":"Leingärtner, Axel, Carl-Philipp J Heisenberg, Roland Kolbeck, Hans Thoenen, and Dan Lindholm. “Brain-Derived Neurotrophic Factor Increases Neurotrophin-3 Expression in Cerebellar Granule Neurons.” <i>Journal of Biological Chemistry</i>. American Society for Biochemistry and Molecular Biology, 1994. <a href=\"https://doi.org/10.1016/s0021-9258(17)42186-7\">https://doi.org/10.1016/s0021-9258(17)42186-7</a>.","apa":"Leingärtner, A., Heisenberg, C.-P. J., Kolbeck, R., Thoenen, H., &#38; Lindholm, D. (1994). Brain-derived neurotrophic factor increases neurotrophin-3 expression in cerebellar granule neurons. <i>Journal of Biological Chemistry</i>. American Society for Biochemistry and Molecular Biology. <a href=\"https://doi.org/10.1016/s0021-9258(17)42186-7\">https://doi.org/10.1016/s0021-9258(17)42186-7</a>"},"month":"01","date_created":"2018-12-11T12:07:25Z","acknowledgement":"We thank Dorothea Stratmann and Karin Angermayer for skillful technical assistance.","article_processing_charge":"No","issue":"2","oa_version":"None","main_file_link":[{"url":"https://www.sciencedirect.com/science/article/pii/S0021925817421867?via%3Dihub","open_access":"1"}],"quality_controlled":"1","scopus_import":"1","title":"Brain-derived neurotrophic factor increases neurotrophin-3 expression in cerebellar granule neurons","intvolume":"       269","language":[{"iso":"eng"}],"publist_id":"1941","date_published":"1994-01-14T00:00:00Z","year":"1994","publisher":"American Society for Biochemistry and Molecular Biology","article_type":"original","day":"14"}