{"year":"1997","publisher":"Elsevier","article_type":"original","day":"01","date_published":"1997-01-01T00:00:00Z","pmid":1,"main_file_link":[{"open_access":"1","url":"https://www.sciencedirect.com/science/article/pii/S0896627301800453?via%3Dihub"}],"quality_controlled":"1","scopus_import":"1","title":"Floating head and masterblind regulate neuronal patterning in the roof of the forebrain","issue":"1","oa_version":"Published Version","publist_id":"1946","intvolume":"        18","language":[{"iso":"eng"}],"status":"public","page":"43 - 57","external_id":{"pmid":["9010204"]},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","oa":1,"acknowledgement":"We thank Igor DaMd. Tom Jessell, David Kimelman. Vladimir Koah, Karen Larison. Ingvild Mikkola, Laurie Molday. and Eric Weinberg for probes and antibod-ies: Alex Schist and Juliet Williams for help with the TUNEL tech-nique; Dominic Delaney for analysis of the fih neural plate: Brian Gashing and Geraldine Millard for fish care; Christian Nusslein Volhard for her support: and Corinne Houart. Nigel Holder, and other members of the DBRC for comments on the manuscript. Electron microscopy of the developing epiphysis cited in this study was carried out with the help of Celeste Malinoski. funded by a grant (EY-00168)awarded to Stephen S. Easter. This study was supported by grants from Welcome Trust to S. W. and Human Frontier Science Program to I. M. S.W. is a Wellcome Trust Senior Research Fellow. ","article_processing_charge":"No","citation":{"ista":"Masai I, Heisenberg C-PJ, Barth KA, Macdonald R, Adamek S, Wilson S. 1997. Floating head and masterblind regulate neuronal patterning in the roof of the forebrain. Neuron. 18(1), 43–57.","chicago":"Masai, Ichiro, Carl-Philipp J Heisenberg, K Anukampa Barth, Rachel Macdonald, Sylwia Adamek, and Stephen Wilson. “Floating Head and Masterblind Regulate Neuronal Patterning in the Roof of the Forebrain.” <i>Neuron</i>. Elsevier, 1997. <a href=\"https://doi.org/10.1016/S0896-6273(01)80045-3\">https://doi.org/10.1016/S0896-6273(01)80045-3</a>.","apa":"Masai, I., Heisenberg, C.-P. J., Barth, K. A., Macdonald, R., Adamek, S., &#38; Wilson, S. (1997). Floating head and masterblind regulate neuronal patterning in the roof of the forebrain. <i>Neuron</i>. Elsevier. <a href=\"https://doi.org/10.1016/S0896-6273(01)80045-3\">https://doi.org/10.1016/S0896-6273(01)80045-3</a>","short":"I. Masai, C.-P.J. Heisenberg, K.A. Barth, R. Macdonald, S. Adamek, S. Wilson, Neuron 18 (1997) 43–57.","ama":"Masai I, Heisenberg C-PJ, Barth KA, Macdonald R, Adamek S, Wilson S. Floating head and masterblind regulate neuronal patterning in the roof of the forebrain. <i>Neuron</i>. 1997;18(1):43-57. doi:<a href=\"https://doi.org/10.1016/S0896-6273(01)80045-3\">10.1016/S0896-6273(01)80045-3</a>","mla":"Masai, Ichiro, et al. “Floating Head and Masterblind Regulate Neuronal Patterning in the Roof of the Forebrain.” <i>Neuron</i>, vol. 18, no. 1, Elsevier, 1997, pp. 43–57, doi:<a href=\"https://doi.org/10.1016/S0896-6273(01)80045-3\">10.1016/S0896-6273(01)80045-3</a>.","ieee":"I. Masai, C.-P. J. Heisenberg, K. A. Barth, R. Macdonald, S. Adamek, and S. Wilson, “Floating head and masterblind regulate neuronal patterning in the roof of the forebrain,” <i>Neuron</i>, vol. 18, no. 1. Elsevier, pp. 43–57, 1997."},"month":"01","date_created":"2018-12-11T12:07:24Z","_id":"4174","doi":"10.1016/S0896-6273(01)80045-3","author":[{"full_name":"Masai, Ichiro","first_name":"Ichiro","last_name":"Masai"},{"orcid":"0000-0002-0912-4566","first_name":"Carl-Philipp J","full_name":"Heisenberg, Carl-Philipp J","id":"39427864-F248-11E8-B48F-1D18A9856A87","last_name":"Heisenberg"},{"first_name":"K Anukampa","full_name":"Barth, K Anukampa","last_name":"Barth"},{"first_name":"Rachel","full_name":"Macdonald, Rachel","last_name":"Macdonald"},{"full_name":"Adamek, Sylwia","first_name":"Sylwia","last_name":"Adamek"},{"full_name":"Wilson, Stephen","first_name":"Stephen","last_name":"Wilson"}],"publication_status":"published","publication":"Neuron","abstract":[{"lang":"eng","text":"The epiphysial region of the dorsal diencephalon is the first site at which neurogenesis occurs in the roof of the zebrafish forebrain. We show that the homeobox containing gene floating head (flh) is required for neurogenesis to proceed in the epiphysis. In flh(-) embryos, the first few epiphysial neurons are generated, but beyond the 18 somite stage, neuronal production ceases. In contrast, in masterblind(-) (mbl(-)) embryos, epiphysial neurons are generated throughout the dorsal forebrain. We show that mbl is required to prevent the expression of flh in dorsal forebrain cells rostral to the epiphysis. Furthermore, epiphysial neurons are not ectopically induced in mbl(-)/flh(-) embryos, demonstrating that the epiphysial phenotype of mbl(-) embryos is mediated by ectopic Flh activity. We propose a role for Flh in linking the signaling pathways that regulate regional patterning to the signaling pathways that regulate neurogenesis."}],"date_updated":"2022-08-18T14:02:49Z","volume":18,"extern":"1","type":"journal_article","publication_identifier":{"issn":["0896-6273"]}}