{"title":"Quantitative approaches in developmental biology","_id":"4165","doi":"10.1038/nrg2548","author":[{"full_name":"Oates, Andrew","first_name":"Andrew","last_name":"Oates"},{"first_name":"Nicole","full_name":"Gorfinkiel, Nicole","last_name":"Gorfinkiel"},{"full_name":"Gonzalez Gaitan, Marcos","first_name":"Marcos","last_name":"Gonzalez Gaitan"},{"id":"39427864-F248-11E8-B48F-1D18A9856A87","last_name":"Heisenberg","orcid":"0000-0002-0912-4566","first_name":"Carl-Philipp J","full_name":"Heisenberg, Carl-Philipp J"}],"oa_version":"None","abstract":[{"lang":"eng","text":"The tissues of a developing embryo are simultaneously patterned, moved and differentiated according to an exchange of information between their constituent cells. We argue that these complex self-organizing phenomena can only be fully understood with quantitative mathematical frameworks that allow specific hypotheses to be formulated and tested. The quantitative and dynamic imaging of growing embryos at the molecular, cellular and tissue level is the key experimental advance required to achieve this interaction between theory and experiment. Here we describe how mathematical modelling has become an invaluable method to integrate quantitative biological information across temporal and spatial scales, serving to connect the activity of regulatory molecules with the morphological development of organisms."}],"publication_status":"published","publication":"Nature Reviews Genetics","issue":"8","extern":"1","type":"journal_article","date_updated":"2021-01-12T07:54:59Z","publist_id":"1953","volume":10,"language":[{"iso":"eng"}],"intvolume":"        10","day":"01","status":"public","year":"2009","publisher":"Nature Publishing Group","page":"517 - 530","date_published":"2009-08-01T00:00:00Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_processing_charge":"No","month":"08","date_created":"2018-12-11T12:07:20Z","citation":{"ieee":"A. Oates, N. Gorfinkiel, M. Gonzalez Gaitan, and C.-P. J. Heisenberg, “Quantitative approaches in developmental biology,” <i>Nature Reviews Genetics</i>, vol. 10, no. 8. Nature Publishing Group, pp. 517–530, 2009.","ama":"Oates A, Gorfinkiel N, Gonzalez Gaitan M, Heisenberg C-PJ. Quantitative approaches in developmental biology. <i>Nature Reviews Genetics</i>. 2009;10(8):517-530. doi:<a href=\"https://doi.org/10.1038/nrg2548\">10.1038/nrg2548</a>","mla":"Oates, Andrew, et al. “Quantitative Approaches in Developmental Biology.” <i>Nature Reviews Genetics</i>, vol. 10, no. 8, Nature Publishing Group, 2009, pp. 517–30, doi:<a href=\"https://doi.org/10.1038/nrg2548\">10.1038/nrg2548</a>.","short":"A. Oates, N. Gorfinkiel, M. Gonzalez Gaitan, C.-P.J. Heisenberg, Nature Reviews Genetics 10 (2009) 517–530.","apa":"Oates, A., Gorfinkiel, N., Gonzalez Gaitan, M., &#38; Heisenberg, C.-P. J. (2009). Quantitative approaches in developmental biology. <i>Nature Reviews Genetics</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/nrg2548\">https://doi.org/10.1038/nrg2548</a>","ista":"Oates A, Gorfinkiel N, Gonzalez Gaitan M, Heisenberg C-PJ. 2009. Quantitative approaches in developmental biology. Nature Reviews Genetics. 10(8), 517–530.","chicago":"Oates, Andrew, Nicole Gorfinkiel, Marcos Gonzalez Gaitan, and Carl-Philipp J Heisenberg. “Quantitative Approaches in Developmental Biology.” <i>Nature Reviews Genetics</i>. Nature Publishing Group, 2009. <a href=\"https://doi.org/10.1038/nrg2548\">https://doi.org/10.1038/nrg2548</a>."}}