{"volume":123,"date_updated":"2022-08-08T08:08:51Z","type":"journal_article","extern":"1","publication_identifier":{"issn":["0950-1991"]},"author":[{"last_name":"Odenthal","full_name":"Odenthal, Jörg","first_name":"Jörg"},{"full_name":"Rossnagel, Karin","first_name":"Karin","last_name":"Rossnagel"},{"last_name":"Haffter","first_name":"Pascal","full_name":"Haffter, Pascal"},{"full_name":"Kelsh, Robert","first_name":"Robert","last_name":"Kelsh"},{"first_name":"Elisabeth","full_name":"Vogelsang, Elisabeth","last_name":"Vogelsang"},{"last_name":"Brand","full_name":"Brand, Michael","first_name":"Michael"},{"last_name":"Van Eeden","first_name":"Fredericus","full_name":"Van Eeden, Fredericus"},{"last_name":"Furutani Seiki","full_name":"Furutani Seiki, Makoto","first_name":"Makoto"},{"first_name":"Michael","full_name":"Granato, Michael","last_name":"Granato"},{"last_name":"Hammerschmidt","full_name":"Hammerschmidt, Matthias","first_name":"Matthias"},{"orcid":"0000-0002-0912-4566","first_name":"Carl-Philipp J","full_name":"Heisenberg, Carl-Philipp J","id":"39427864-F248-11E8-B48F-1D18A9856A87","last_name":"Heisenberg"},{"first_name":"Yunjin","full_name":"Jiang, Yunjin","last_name":"Jiang"},{"last_name":"Kane","first_name":"Donald","full_name":"Kane, Donald"},{"last_name":"Mullins","first_name":"Mary","full_name":"Mullins, Mary"},{"first_name":"Christiane","full_name":"Nüsslein Volhard, Christiane","last_name":"Nüsslein Volhard"}],"doi":"10.1242/dev.123.1.391","_id":"4164","publication_status":"published","publication":"Development","abstract":[{"lang":"eng","text":"In a large-scale screen for mutants with defects in embryonic development we identified 17 genes (65 mutants) specifically required for the development of xanthophores, We provide evidence that these genes are required for three different aspects of xanthophore development, (1) Pigment cell formation and migration (pfeffer and salt); (2) pigment synthesis (edison, yobo, yocca and brie) and (3) pigment translocation (esrom, tilsit and tofu). The number of xanthophore cells that appear in the body is reduced in embryos with mutations in the two genes, salt and pfeffer. In heterozygous and homozygous salt and pfeffer adults, the melanophore stripes are interrupted, indicating that xanthophore cells have an important function in adult melanophore pattern formation, Most other genes affect only larval pigmentation, In embryos mutant for edison, yobo, yocca and brie, differences in pteridine synthesis can be observed under UV light and by thin-layer chromatography. Homozygous mutant females of yobo show a recessive maternal effect, Embryonic development is slowed down and embryos display head and tail truncations, Xanthophores in larvae mutant in the three genes esrom, tilsit and tofu appear less spread out, In addition, these mutants display a defect in retinotectal axon pathfinding, These mutations may affect xanthophore pigment distribution within the cells or xanthophore cell shape, Mutations in seven genes affecting xanthophore pigmentation remain unclassified."}],"article_processing_charge":"No","acknowledgement":"We thank Silke Rudolph for technical assistance, Joel Wilson and Cornelia Fricke for their help in the fish work and the thin layer chromatography, and Darren Gilmour for help with the manuscript.","citation":{"ama":"Odenthal J, Rossnagel K, Haffter P, et al. Mutations affecting xanthophore pigmentation in the zebrafish, Danio rerio. <i>Development</i>. 1996;123(1):391-398. doi:<a href=\"https://doi.org/10.1242/dev.123.1.391\">10.1242/dev.123.1.391</a>","mla":"Odenthal, Jörg, et al. “Mutations Affecting Xanthophore Pigmentation in the Zebrafish, Danio Rerio.” <i>Development</i>, vol. 123, no. 1, Company of Biologists, 1996, pp. 391–98, doi:<a href=\"https://doi.org/10.1242/dev.123.1.391\">10.1242/dev.123.1.391</a>.","short":"J. Odenthal, K. Rossnagel, P. Haffter, R. Kelsh, E. Vogelsang, M. Brand, F. Van Eeden, M. Furutani Seiki, M. Granato, M. Hammerschmidt, C.-P.J. Heisenberg, Y. Jiang, D. Kane, M. Mullins, C. Nüsslein Volhard, Development 123 (1996) 391–398.","ieee":"J. Odenthal <i>et al.</i>, “Mutations affecting xanthophore pigmentation in the zebrafish, Danio rerio,” <i>Development</i>, vol. 123, no. 1. Company of Biologists, pp. 391–398, 1996.","ista":"Odenthal J, Rossnagel K, Haffter P, Kelsh R, Vogelsang E, Brand M, Van Eeden F, Furutani Seiki M, Granato M, Hammerschmidt M, Heisenberg C-PJ, Jiang Y, Kane D, Mullins M, Nüsslein Volhard C. 1996. Mutations affecting xanthophore pigmentation in the zebrafish, Danio rerio. Development. 123(1), 391–398.","chicago":"Odenthal, Jörg, Karin Rossnagel, Pascal Haffter, Robert Kelsh, Elisabeth Vogelsang, Michael Brand, Fredericus Van Eeden, et al. “Mutations Affecting Xanthophore Pigmentation in the Zebrafish, Danio Rerio.” <i>Development</i>. Company of Biologists, 1996. <a href=\"https://doi.org/10.1242/dev.123.1.391\">https://doi.org/10.1242/dev.123.1.391</a>.","apa":"Odenthal, J., Rossnagel, K., Haffter, P., Kelsh, R., Vogelsang, E., Brand, M., … Nüsslein Volhard, C. (1996). Mutations affecting xanthophore pigmentation in the zebrafish, Danio rerio. <i>Development</i>. Company of Biologists. <a href=\"https://doi.org/10.1242/dev.123.1.391\">https://doi.org/10.1242/dev.123.1.391</a>"},"date_created":"2018-12-11T12:07:20Z","month":"12","page":"391 - 398","status":"public","external_id":{"pmid":["9007257 "]},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publist_id":"1955","intvolume":"       123","language":[{"iso":"eng"}],"title":"Mutations affecting xanthophore pigmentation in the zebrafish, Danio rerio","quality_controlled":"1","scopus_import":"1","issue":"1","oa_version":"None","pmid":1,"year":"1996","article_type":"original","publisher":"Company of Biologists","day":"01","date_published":"1996-12-01T00:00:00Z"}