{"has_accepted_license":"1","author":[{"first_name":"Frédéric","last_name":"Didier","full_name":"Didier, Frédéric"},{"full_name":"Henzinger, Thomas A","id":"40876CD8-F248-11E8-B48F-1D18A9856A87","last_name":"Henzinger","first_name":"Thomas A","orcid":"0000−0002−2985−7724"},{"full_name":"Mateescu, Maria","first_name":"Maria","last_name":"Mateescu"},{"first_name":"Verena","last_name":"Wolf","full_name":"Wolf, Verena"}],"publication":"IET Systems Biology","page":"441 - 452","doi":"10.1049/iet-syb.2010.0005","_id":"3842","pubrep_id":"66","language":[{"iso":"eng"}],"citation":{"ieee":"F. Didier, T. A. Henzinger, M. Mateescu, and V. Wolf, “Fast adaptive uniformization of the chemical master equation,” <i>IET Systems Biology</i>, vol. 4, no. 6. Institution of Engineering and Technology, pp. 441–452, 2010.","mla":"Didier, Frédéric, et al. “Fast Adaptive Uniformization of the Chemical Master Equation.” <i>IET Systems Biology</i>, vol. 4, no. 6, Institution of Engineering and Technology, 2010, pp. 441–52, doi:<a href=\"https://doi.org/10.1049/iet-syb.2010.0005\">10.1049/iet-syb.2010.0005</a>.","short":"F. Didier, T.A. Henzinger, M. Mateescu, V. Wolf, IET Systems Biology 4 (2010) 441–452.","ista":"Didier F, Henzinger TA, Mateescu M, Wolf V. 2010. Fast adaptive uniformization of the chemical master equation. IET Systems Biology. 4(6), 441–452.","apa":"Didier, F., Henzinger, T. A., Mateescu, M., &#38; Wolf, V. (2010). Fast adaptive uniformization of the chemical master equation. <i>IET Systems Biology</i>. Institution of Engineering and Technology. <a href=\"https://doi.org/10.1049/iet-syb.2010.0005\">https://doi.org/10.1049/iet-syb.2010.0005</a>","chicago":"Didier, Frédéric, Thomas A Henzinger, Maria Mateescu, and Verena Wolf. “Fast Adaptive Uniformization of the Chemical Master Equation.” <i>IET Systems Biology</i>. Institution of Engineering and Technology, 2010. <a href=\"https://doi.org/10.1049/iet-syb.2010.0005\">https://doi.org/10.1049/iet-syb.2010.0005</a>.","ama":"Didier F, Henzinger TA, Mateescu M, Wolf V. Fast adaptive uniformization of the chemical master equation. <i>IET Systems Biology</i>. 2010;4(6):441-452. doi:<a href=\"https://doi.org/10.1049/iet-syb.2010.0005\">10.1049/iet-syb.2010.0005</a>"},"year":"2010","intvolume":"         4","volume":4,"publist_id":"2349","ddc":["570"],"file_date_updated":"2020-07-14T12:46:16Z","month":"11","date_updated":"2023-02-23T11:45:08Z","type":"journal_article","file":[{"content_type":"application/pdf","creator":"system","access_level":"open_access","file_name":"IST-2012-66-v1+1_Fast_adaptive_uniformization_of_the_chemical_master_equation.pdf","checksum":"9a3bde48f43203991a0b3c6a277c2f5b","relation":"main_file","file_id":"5254","file_size":222890,"date_created":"2018-12-12T10:17:02Z","date_updated":"2020-07-14T12:46:16Z"}],"day":"15","department":[{"_id":"ToHe"}],"abstract":[{"lang":"eng","text":"Within systems biology there is an increasing interest in the stochastic behavior of biochemical reaction networks. An appropriate stochastic description is provided by the chemical master equation, which represents a continuous-time Markov chain (CTMC). The uniformization technique is an efficient method to compute probability distributions of a CTMC if the number of states is manageable. However, the size of a CTMC that represents a biochemical reaction network is usually far beyond what is feasible. In this paper we present an on-the-fly variant of uniformization, where we improve the original algorithm at the cost of a small approximation error. By means of several examples, we show that our approach is particularly well-suited for biochemical reaction networks."}],"publication_status":"published","date_published":"2010-11-15T00:00:00Z","issue":"6","publisher":"Institution of Engineering and Technology","scopus_import":1,"oa_version":"Submitted Version","oa":1,"user_id":"4435EBFC-F248-11E8-B48F-1D18A9856A87","date_created":"2018-12-11T12:05:28Z","quality_controlled":"1","title":"Fast adaptive uniformization of the chemical master equation","status":"public","related_material":{"record":[{"status":"public","relation":"earlier_version","id":"3843"}]}}