{"status":"public","publisher":"American Association for the Advancement of Science","year":"2004","page":"265 - 70","day":"01","date_published":"2004-01-01T00:00:00Z","citation":{"ieee":"D. Oliver, C. Lien, M. Soom, T. Baukrowitz, P. M. Jonas, and B. Fakler, “Functional conversion between A-type and delayed rectifier K+ channels by membrane lipids,” <i>Science</i>, vol. 304, no. 5668. American Association for the Advancement of Science, pp. 265–70, 2004.","short":"D. Oliver, C. Lien, M. Soom, T. Baukrowitz, P.M. Jonas, B. Fakler, Science 304 (2004) 265–70.","mla":"Oliver, Dominik, et al. “Functional Conversion between A-Type and Delayed Rectifier K+ Channels by Membrane Lipids.” <i>Science</i>, vol. 304, no. 5668, American Association for the Advancement of Science, 2004, pp. 265–70, doi:<a href=\"https://doi.org/10.1126/science.1094113\">10.1126/science.1094113</a>.","ama":"Oliver D, Lien C, Soom M, Baukrowitz T, Jonas PM, Fakler B. Functional conversion between A-type and delayed rectifier K+ channels by membrane lipids. <i>Science</i>. 2004;304(5668):265-270. doi:<a href=\"https://doi.org/10.1126/science.1094113\">10.1126/science.1094113</a>","apa":"Oliver, D., Lien, C., Soom, M., Baukrowitz, T., Jonas, P. M., &#38; Fakler, B. (2004). Functional conversion between A-type and delayed rectifier K+ channels by membrane lipids. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.1094113\">https://doi.org/10.1126/science.1094113</a>","chicago":"Oliver, Dominik, Cheng Lien, Malle Soom, Thomas Baukrowitz, Peter M Jonas, and Bernd Fakler. “Functional Conversion between A-Type and Delayed Rectifier K+ Channels by Membrane Lipids.” <i>Science</i>. American Association for the Advancement of Science, 2004. <a href=\"https://doi.org/10.1126/science.1094113\">https://doi.org/10.1126/science.1094113</a>.","ista":"Oliver D, Lien C, Soom M, Baukrowitz T, Jonas PM, Fakler B. 2004. Functional conversion between A-type and delayed rectifier K+ channels by membrane lipids. Science. 304(5668), 265–70."},"month":"01","date_created":"2018-12-11T12:05:18Z","_id":"3810","doi":"10.1126/science.1094113","author":[{"last_name":"Oliver","full_name":"Oliver, Dominik","first_name":"Dominik"},{"first_name":"Cheng","full_name":"Lien, Cheng-Chang","last_name":"Lien"},{"first_name":"Malle","full_name":"Soom, Malle","last_name":"Soom"},{"last_name":"Baukrowitz","full_name":"Baukrowitz, Thomas","first_name":"Thomas"},{"id":"353C1B58-F248-11E8-B48F-1D18A9856A87","last_name":"Jonas","orcid":"0000-0001-5001-4804","full_name":"Peter Jonas","first_name":"Peter M"},{"full_name":"Fakler, Bernd","first_name":"Bernd","last_name":"Fakler"}],"quality_controlled":0,"title":"Functional conversion between A-type and delayed rectifier K+ channels by membrane lipids","publication_status":"published","issue":"5668","publication":"Science","abstract":[{"text":"Voltage-gated potassium (Kv) channels control action potential repolarization, interspike membrane potential, and action potential frequency in excitable cells. It is thought that the combinatorial association between distinct alpha and beta subunits determines whether Kv channels function as non-inactivating delayed rectifiers or as rapidly inactivating A-type channels. We show that membrane lipids can convert A-type channels into delayed rectifiers and vice versa. Phosphoinositides remove N-type inactivation from A-type channels by immobilizing the inactivation domains. Conversely, arachidonic acid and its amide anandamide endow delayed rectifiers with rapid voltage-dependent inactivation. The bidirectional control of Kv channel gating by lipids may provide a mechanism for the dynamic regulation of electrical signaling in the nervous system.","lang":"eng"}],"date_updated":"2021-01-12T07:52:22Z","publist_id":"2402","volume":304,"extern":1,"type":"journal_article","intvolume":"       304"}