{"status":"public","quality_controlled":0,"title":"Optimizing information flow in small genetic networks","year":"2009","publisher":"American Institute of Physics","volume":80,"date_created":"2018-12-11T12:04:53Z","publist_id":"2493","intvolume":"        80","main_file_link":[{"open_access":"0","url":"http://arxiv.org/abs/0903.4491"}],"abstract":[{"lang":"eng","text":"In order to survive, reproduce, and (in multicellular organisms) differentiate, cells must control the concentrations of the myriad different proteins that are encoded in the genome. The precision of this control is limited by the inevitable randomness of individual molecular events. Here we explore how cells can maximize their control power in the presence of these physical limits; formally, we solve the theoretical problem of maximizing the information transferred from inputs to outputs when the number of available molecules is held fixed. We start with the simplest version of the problem, in which a single transcription factor protein controls the readout of one or more genes by binding to DNA. We further simplify by assuming that this regulatory network operates in steady state, that the noise is small relative to the available dynamic range, and that the target genes do not interact. Even in this simple limit, we find a surprisingly rich set of optimal solutions. Importantly, for each locally optimal regulatory network, all parameters are determined once the physical constraints on the number of available molecules are specified. Although we are solving an oversimplified version of the problem facing real cells, we see parallels between the structure of these optimal solutions and the behavior of actual genetic regulatory networks. Subsequent papers will discuss more complete versions of the problem."}],"_id":"3737","issue":"3 ","date_published":"2009-09-29T00:00:00Z","citation":{"ieee":"G. Tkačik, A. Walczak, and W. Bialek, “Optimizing information flow in small genetic networks,” <i>Physical Review E Statistical Nonlinear and Soft Matter Physics</i>, vol. 80, no. 3. American Institute of Physics, 2009.","mla":"Tkačik, Gašper, et al. “Optimizing Information Flow in Small Genetic Networks.” <i>Physical Review E Statistical Nonlinear and Soft Matter Physics</i>, vol. 80, no. 3, American Institute of Physics, 2009, doi:<a href=\"https://doi.org/10.1103/PhysRevE.80.031920\">10.1103/PhysRevE.80.031920</a>.","short":"G. Tkačik, A. Walczak, W. Bialek, Physical Review E Statistical Nonlinear and Soft Matter Physics 80 (2009).","ama":"Tkačik G, Walczak A, Bialek W. Optimizing information flow in small genetic networks. <i>Physical Review E Statistical Nonlinear and Soft Matter Physics</i>. 2009;80(3). doi:<a href=\"https://doi.org/10.1103/PhysRevE.80.031920\">10.1103/PhysRevE.80.031920</a>","ista":"Tkačik G, Walczak A, Bialek W. 2009. Optimizing information flow in small genetic networks. Physical Review E Statistical Nonlinear and Soft Matter Physics. 80(3).","chicago":"Tkačik, Gašper, Aleksandra Walczak, and William Bialek. “Optimizing Information Flow in Small Genetic Networks.” <i>Physical Review E Statistical Nonlinear and Soft Matter Physics</i>. American Institute of Physics, 2009. <a href=\"https://doi.org/10.1103/PhysRevE.80.031920\">https://doi.org/10.1103/PhysRevE.80.031920</a>.","apa":"Tkačik, G., Walczak, A., &#38; Bialek, W. (2009). Optimizing information flow in small genetic networks. <i>Physical Review E Statistical Nonlinear and Soft Matter Physics</i>. American Institute of Physics. <a href=\"https://doi.org/10.1103/PhysRevE.80.031920\">https://doi.org/10.1103/PhysRevE.80.031920</a>"},"publication_status":"published","extern":1,"date_updated":"2021-01-12T07:51:50Z","month":"09","author":[{"orcid":"0000-0002-6699-1455","last_name":"Tkacik","first_name":"Gasper","id":"3D494DCA-F248-11E8-B48F-1D18A9856A87","full_name":"Gasper Tkacik"},{"first_name":"Aleksandra","last_name":"Walczak","full_name":"Walczak, Aleksandra M"},{"first_name":"William","last_name":"Bialek","full_name":"Bialek, William S"}],"publication":"Physical Review E Statistical Nonlinear and Soft Matter Physics","day":"29","doi":"10.1103/PhysRevE.80.031920","type":"journal_article"}