{"language":[{"iso":"eng"}],"_id":"3642","citation":{"ama":"Turelli M, Barton NH. Genetic and statistical analyses of strong selection on polygenic traits: What, me normal? <i>Genetics</i>. 1994;138(3):913-941. doi:<a href=\"https://doi.org/10.1093/genetics/138.3.913\">10.1093/genetics/138.3.913</a>","ista":"Turelli M, Barton NH. 1994. Genetic and statistical analyses of strong selection on polygenic traits: What, me normal? Genetics. 138(3), 913–941.","apa":"Turelli, M., &#38; Barton, N. H. (1994). Genetic and statistical analyses of strong selection on polygenic traits: What, me normal? <i>Genetics</i>. Genetics Society of America. <a href=\"https://doi.org/10.1093/genetics/138.3.913\">https://doi.org/10.1093/genetics/138.3.913</a>","chicago":"Turelli, Michael, and Nicholas H Barton. “Genetic and Statistical Analyses of Strong Selection on Polygenic Traits: What, Me Normal?” <i>Genetics</i>. Genetics Society of America, 1994. <a href=\"https://doi.org/10.1093/genetics/138.3.913\">https://doi.org/10.1093/genetics/138.3.913</a>.","short":"M. Turelli, N.H. Barton, Genetics 138 (1994) 913–941.","mla":"Turelli, Michael, and Nicholas H. Barton. “Genetic and Statistical Analyses of Strong Selection on Polygenic Traits: What, Me Normal?” <i>Genetics</i>, vol. 138, no. 3, Genetics Society of America, 1994, pp. 913–41, doi:<a href=\"https://doi.org/10.1093/genetics/138.3.913\">10.1093/genetics/138.3.913</a>.","ieee":"M. Turelli and N. H. Barton, “Genetic and statistical analyses of strong selection on polygenic traits: What, me normal?,” <i>Genetics</i>, vol. 138, no. 3. Genetics Society of America, pp. 913–941, 1994."},"article_type":"original","publication_identifier":{"issn":["0016-6731"]},"external_id":{"pmid":["7851785"]},"page":"913 - 941","doi":"10.1093/genetics/138.3.913","author":[{"last_name":"Turelli","first_name":"Michael","full_name":"Turelli, Michael"},{"id":"4880FE40-F248-11E8-B48F-1D18A9856A87","full_name":"Barton, Nicholas H","last_name":"Barton","first_name":"Nicholas H","orcid":"0000-0002-8548-5240"}],"publication":"Genetics","year":"1994","publist_id":"2741","volume":138,"intvolume":"       138","main_file_link":[{"url":"https://pubmed.ncbi.nlm.nih.gov/7851785/","open_access":"1"}],"abstract":[{"text":"We develop a general population genetic framework for analyzing selection on many loci, and apply it to strong truncation and disruptive selection on an additive polygenic trait. We first present statistical methods for analyzing the infinitesimal model, in which offspring breeding values are normally distributed around the mean of the parents, with fixed variance. These show that the usual assumption of a Gaussian distribution of breeding values in the population gives remarkably accurate predictions for the mean and the variance, even when disruptive selection generates substantial deviations from normality. We then set out a general genetic analysis of selection and recombination. The population is represented by multilocus cumulants describing the distribution of haploid genotypes, and selection is described by the relation between mean fitness and these cumulants. We provide exact recursions in terms of generating functions for the effects of selection on non-central moments. The effects of recombination are simply calculated as a weighted sum over all the permutations produced by meiosis. Finally, the new cumulants that describe the next generation are computed from the non-central moments. Although this scheme is applied here in detail only to selection on an additive trait, it is quite general. For arbitrary epistasis and linkage, we describe a consistent infinitesimal limit in which the short-term selection response is dominated by infinitesimal allele frequency changes and linkage disequilibria. Numerical multilocus results show that the standard Gaussian approximation gives accurate predictions for the dynamics of the mean and genetic variance in this limit. Even with intense truncation selection, linkage disequilibria of order three and higher never cause much deviation from normality. Thus, the empirical deviations frequently found between predicted and observed responses to artificial selection are not caused by linkage-disequilibrium-induced departures from normality. Disruptive selection can generate substantial four-way disequilibria, and hence kurtosis; but even then, the Gaussian assumption predicts the variance accurately. In contrast to the apparent simplicity of the infinitesimal limit, data suggest that changes in genetic variance after 10 or more generations of selection are likely to be dominated by allele frequency dynamics that depend on genetic details.","lang":"eng"}],"issue":"3","extern":"1","date_published":"1994-11-01T00:00:00Z","publication_status":"published","pmid":1,"date_updated":"2022-06-03T08:18:54Z","article_processing_charge":"No","month":"11","day":"01","type":"journal_article","status":"public","title":"Genetic and statistical analyses of strong selection on polygenic traits: What, me normal?","quality_controlled":"1","publisher":"Genetics Society of America","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","date_created":"2018-12-11T12:04:24Z","oa":1,"oa_version":"Published Version"}