{"pmid":1,"article_type":"original","publisher":"Society for Neuroscience","year":"1999","day":"01","date_published":"1999-11-01T00:00:00Z","publist_id":"2866","intvolume":"        19","language":[{"iso":"eng"}],"main_file_link":[{"open_access":"1","url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6782894/"}],"quality_controlled":"1","scopus_import":"1","title":"Replay and time compression of recurring spike sequences in the hippocampus","issue":"21","oa_version":"Published Version","acknowledgement":"This work was supported by National Institutes of Health Grants NS34994 and MH54671 and by the Human Science Frontier Program. We thank Moshe Abeles, Michale Fee, Stuart Geman, Stephen Hanson, Darrell Henze, Günther Palm, Michael Recce, and Matthew Wilson for their suggestions with data analysis and comments on this manuscript.","article_processing_charge":"No","citation":{"apa":"Nádasdy, Z., Hirase, H., Czurkó, A., Csicsvari, J. L., &#38; Buzsáki, G. (1999). Replay and time compression of recurring spike sequences in the hippocampus. <i>Journal of Neuroscience</i>. Society for Neuroscience. <a href=\"https://doi.org/10.1523/JNEUROSCI.19-21-09497.1999\">https://doi.org/10.1523/JNEUROSCI.19-21-09497.1999</a>","chicago":"Nádasdy, Zoltán, Hajima Hirase, András Czurkó, Jozsef L Csicsvari, and György Buzsáki. “Replay and Time Compression of Recurring Spike Sequences in the Hippocampus.” <i>Journal of Neuroscience</i>. Society for Neuroscience, 1999. <a href=\"https://doi.org/10.1523/JNEUROSCI.19-21-09497.1999\">https://doi.org/10.1523/JNEUROSCI.19-21-09497.1999</a>.","ista":"Nádasdy Z, Hirase H, Czurkó A, Csicsvari JL, Buzsáki G. 1999. Replay and time compression of recurring spike sequences in the hippocampus. Journal of Neuroscience. 19(21), 9497–9507.","ieee":"Z. Nádasdy, H. Hirase, A. Czurkó, J. L. Csicsvari, and G. Buzsáki, “Replay and time compression of recurring spike sequences in the hippocampus,” <i>Journal of Neuroscience</i>, vol. 19, no. 21. Society for Neuroscience, pp. 9497–9507, 1999.","short":"Z. Nádasdy, H. Hirase, A. Czurkó, J.L. Csicsvari, G. Buzsáki, Journal of Neuroscience 19 (1999) 9497–9507.","mla":"Nádasdy, Zoltán, et al. “Replay and Time Compression of Recurring Spike Sequences in the Hippocampus.” <i>Journal of Neuroscience</i>, vol. 19, no. 21, Society for Neuroscience, 1999, pp. 9497–507, doi:<a href=\"https://doi.org/10.1523/JNEUROSCI.19-21-09497.1999\">10.1523/JNEUROSCI.19-21-09497.1999</a>.","ama":"Nádasdy Z, Hirase H, Czurkó A, Csicsvari JL, Buzsáki G. Replay and time compression of recurring spike sequences in the hippocampus. <i>Journal of Neuroscience</i>. 1999;19(21):9497-9507. doi:<a href=\"https://doi.org/10.1523/JNEUROSCI.19-21-09497.1999\">10.1523/JNEUROSCI.19-21-09497.1999</a>"},"month":"11","date_created":"2018-12-11T12:03:45Z","status":"public","page":"9497 - 9507","external_id":{"pmid":["10531452"]},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","oa":1,"date_updated":"2022-09-07T12:48:08Z","volume":19,"extern":"1","type":"journal_article","publication_identifier":{"issn":["0270-6474"]},"_id":"3518","doi":"10.1523/JNEUROSCI.19-21-09497.1999","author":[{"last_name":"Nádasdy","first_name":"Zoltán","full_name":"Nádasdy, Zoltán"},{"full_name":"Hirase, Hajima","first_name":"Hajima","last_name":"Hirase"},{"last_name":"Czurkó","full_name":"Czurkó, András","first_name":"András"},{"last_name":"Csicsvari","id":"3FA14672-F248-11E8-B48F-1D18A9856A87","full_name":"Csicsvari, Jozsef L","first_name":"Jozsef L","orcid":"0000-0002-5193-4036"},{"full_name":"Buzsáki, György","first_name":"György","last_name":"Buzsáki"}],"publication":"Journal of Neuroscience","publication_status":"published","abstract":[{"text":"Information in neuronal networks may be represented by the spatiotemporal patterns of spikes. Here we examined the temporal coordination of pyramidal cell spikes in the rat hippocampus during slow-wave sleep. In addition, rats were trained to run in a defined position in space (running wheel) to activate a selected group of pyramidal cells. A template-matching method and a joint probability map method were used for sequence search. Repeating spike sequences in excess of chance occurrence were examined by comparing the number of repeating sequences in the original spike trains and in surrogate trains after Monte Carlo shuffling of the spikes. Four different shuffling procedures were used to control for the population dynamics of hippocampal neurons. Repeating spike sequences in the recorded cell assemblies were present in both the awake and sleeping animal in excess of what might be predicted by random variations. Spike sequences observed during wheel running were “replayed” at a faster timescale during single sharp-wave bursts of slow-wave sleep. We hypothesize that the endogenously expressed spike sequences during sleep reflect reactivation of the circuitry modified by previous experience. Reactivation of acquired sequences may serve to consolidate information.","lang":"eng"}]}