{"publication_identifier":{"issn":["0896-6273"]},"extern":"1","type":"journal_article","date_updated":"2023-05-02T14:34:37Z","volume":28,"abstract":[{"lang":"eng","text":"Analysis of presynaptic determinants of synaptic strength has been difficult at cortical synapses, mainly due to the lack of direct access to presynaptic elements. Here we report patch-clamp recordings from mossy fiber boutons (MFBs) in rat hippocampal slices. The presynaptic action potential is very short during low-frequency stimulation but is prolonged up to 3-fold during high-frequency stimulation. Voltage-gated K+ channels in MFBs inactivate rapidly but recover from inactivation very slowly, suggesting that cumulative K+ channel inactivation mediates activity-dependent spike broadening. Prolongation of the presynaptic voltage waveform leads to an increase in the number of Ca2+ ions entering the terminal per action potential and to a consecutive potentiation of evoked excitatory postsynaptic currents at MFB-CA3 pyramidal cell synapses. Thus, inactivation of presynaptic K+ channels contributes to the control of efficacy of a glutamatergic synapse in the cortex."}],"publication_status":"published","publication":"Neuron","_id":"3492","doi":"10.1016/S0896-6273(00)00164-1","author":[{"first_name":"Jörg","full_name":"Geiger, Jörg","last_name":"Geiger"},{"orcid":"0000-0001-5001-4804","first_name":"Peter M","full_name":"Jonas, Peter M","id":"353C1B58-F248-11E8-B48F-1D18A9856A87","last_name":"Jonas"}],"month":"12","date_created":"2018-12-11T12:03:37Z","citation":{"chicago":"Geiger, Jörg, and Peter M Jonas. “Dynamic Control of Presynaptic Ca(2+) Inflow by Fast-Inactivating K+ Channels in Hippocampal Mossy Fiber Boutons.” <i>Neuron</i>. Elsevier, 2000. <a href=\"https://doi.org/10.1016/S0896-6273(00)00164-1\">https://doi.org/10.1016/S0896-6273(00)00164-1</a>.","ista":"Geiger J, Jonas PM. 2000. Dynamic control of presynaptic Ca(2+) inflow by fast-inactivating K+ channels in hippocampal mossy fiber boutons. Neuron. 28(3), 927–939.","apa":"Geiger, J., &#38; Jonas, P. M. (2000). Dynamic control of presynaptic Ca(2+) inflow by fast-inactivating K+ channels in hippocampal mossy fiber boutons. <i>Neuron</i>. Elsevier. <a href=\"https://doi.org/10.1016/S0896-6273(00)00164-1\">https://doi.org/10.1016/S0896-6273(00)00164-1</a>","mla":"Geiger, Jörg, and Peter M. Jonas. “Dynamic Control of Presynaptic Ca(2+) Inflow by Fast-Inactivating K+ Channels in Hippocampal Mossy Fiber Boutons.” <i>Neuron</i>, vol. 28, no. 3, Elsevier, 2000, pp. 927–39, doi:<a href=\"https://doi.org/10.1016/S0896-6273(00)00164-1\">10.1016/S0896-6273(00)00164-1</a>.","ama":"Geiger J, Jonas PM. Dynamic control of presynaptic Ca(2+) inflow by fast-inactivating K+ channels in hippocampal mossy fiber boutons. <i>Neuron</i>. 2000;28(3):927-939. doi:<a href=\"https://doi.org/10.1016/S0896-6273(00)00164-1\">10.1016/S0896-6273(00)00164-1</a>","short":"J. Geiger, P.M. Jonas, Neuron 28 (2000) 927–939.","ieee":"J. Geiger and P. M. Jonas, “Dynamic control of presynaptic Ca(2+) inflow by fast-inactivating K+ channels in hippocampal mossy fiber boutons,” <i>Neuron</i>, vol. 28, no. 3. Elsevier, pp. 927–939, 2000."},"article_processing_charge":"No","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","external_id":{"pmid":["11163277"]},"status":"public","page":"927 - 939","language":[{"iso":"eng"}],"intvolume":"        28","publist_id":"2895","oa_version":"None","issue":"3","quality_controlled":"1","title":"Dynamic control of presynaptic Ca(2+) inflow by fast-inactivating K+ channels in hippocampal mossy fiber boutons","pmid":1,"date_published":"2000-12-01T00:00:00Z","day":"01","year":"2000","publisher":"Elsevier","article_type":"original"}