{"doi":"10.1016/S0896-6273(00)80339-6","author":[{"first_name":"Jörg","full_name":"Geiger, Jörg","last_name":"Geiger"},{"full_name":"Lubke, Joachim","first_name":"Joachim","last_name":"Lubke"},{"first_name":"Arnd","full_name":"Roth, Arnd","last_name":"Roth"},{"last_name":"Frotscher","full_name":"Frotscher, Michael","first_name":"Michael"},{"last_name":"Jonas","id":"353C1B58-F248-11E8-B48F-1D18A9856A87","first_name":"Peter M","full_name":"Jonas, Peter M","orcid":"0000-0001-5001-4804"}],"_id":"3484","publication":"Neuron","publication_status":"published","abstract":[{"lang":"eng","text":"Glutamatergic transmission at a principal neuroninterneuron synapse was investigated by dual whole-cell patch-clamp recording in rat hippocampal slices combined with morphological analysis. Evoked EPSPs with rapid time course (half duration ≃ 4 ms; 34°C) were generated at multiple synaptic contacts established on the interneuron dendrites close to the soma. The underlying postsynaptic conductance change showed a submillisecond rise and decay, due to the precise timing of glutamate release and the rapid deactivation of the postsynaptic AMPA receptors. Simulations based on a compartmental model of the interneuron indicated that the rapid postsynaptic conductance change determines the shape and the somatodendritic integration of EPSPs, thus enabling interneurons to detect synchronous principal neuron activity."}],"volume":18,"date_updated":"2022-08-22T08:41:54Z","type":"journal_article","extern":"1","publication_identifier":{"issn":["0896-6273"]},"page":"1009 - 1023","status":"public","external_id":{"pmid":["9208867 "]},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","oa":1,"article_processing_charge":"No","acknowledgement":"We thank Drs. J. Bischofberger, M. Ha¨usser, and I. Vida for critically T.F. reading the manuscript; S. Nestel, B. Joch, M. Winter, B. Freudenberg, and K. Zipfel for excellent technical assistance; and B. Hillers Hestrin, S. for typing. Supported by the DFG (SFB 505/C5 to P. J. and Leibniz program to M. F.)","citation":{"short":"J. Geiger, J. Lubke, A. Roth, M. Frotscher, P.M. Jonas, Neuron 18 (1997) 1009–1023.","ama":"Geiger J, Lubke J, Roth A, Frotscher M, Jonas PM. Submillisecond AMPA receptor-mediated signaling at a principal neuron-interneuron synapse. <i>Neuron</i>. 1997;18(6):1009-1023. doi:<a href=\"https://doi.org/10.1016/S0896-6273(00)80339-6\">10.1016/S0896-6273(00)80339-6</a>","mla":"Geiger, Jörg, et al. “Submillisecond AMPA Receptor-Mediated Signaling at a Principal Neuron-Interneuron Synapse.” <i>Neuron</i>, vol. 18, no. 6, Elsevier, 1997, pp. 1009–23, doi:<a href=\"https://doi.org/10.1016/S0896-6273(00)80339-6\">10.1016/S0896-6273(00)80339-6</a>.","ieee":"J. Geiger, J. Lubke, A. Roth, M. Frotscher, and P. M. Jonas, “Submillisecond AMPA receptor-mediated signaling at a principal neuron-interneuron synapse,” <i>Neuron</i>, vol. 18, no. 6. Elsevier, pp. 1009–1023, 1997.","ista":"Geiger J, Lubke J, Roth A, Frotscher M, Jonas PM. 1997. Submillisecond AMPA receptor-mediated signaling at a principal neuron-interneuron synapse. Neuron. 18(6), 1009–1023.","chicago":"Geiger, Jörg, Joachim Lubke, Arnd Roth, Michael Frotscher, and Peter M Jonas. “Submillisecond AMPA Receptor-Mediated Signaling at a Principal Neuron-Interneuron Synapse.” <i>Neuron</i>. Elsevier, 1997. <a href=\"https://doi.org/10.1016/S0896-6273(00)80339-6\">https://doi.org/10.1016/S0896-6273(00)80339-6</a>.","apa":"Geiger, J., Lubke, J., Roth, A., Frotscher, M., &#38; Jonas, P. M. (1997). Submillisecond AMPA receptor-mediated signaling at a principal neuron-interneuron synapse. <i>Neuron</i>. Elsevier. <a href=\"https://doi.org/10.1016/S0896-6273(00)80339-6\">https://doi.org/10.1016/S0896-6273(00)80339-6</a>"},"date_created":"2018-12-11T12:03:34Z","month":"06","main_file_link":[{"url":"https://www.sciencedirect.com/science/article/pii/S0896627300803396?via%3Dihub","open_access":"1"}],"title":"Submillisecond AMPA receptor-mediated signaling at a principal neuron-interneuron synapse","scopus_import":"1","quality_controlled":"1","issue":"6","oa_version":"None","publist_id":"2903","intvolume":"        18","language":[{"iso":"eng"}],"year":"1997","publisher":"Elsevier","article_type":"original","day":"01","date_published":"1997-06-01T00:00:00Z","pmid":1}