{"oa":1,"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","external_id":{"pmid":["2550937 "]},"status":"public","page":"7238 - 7242","month":"09","date_created":"2018-12-11T12:03:28Z","citation":{"ieee":"P. M. Jonas, M. Bräu, M. Hermsteiner, and W. Vogel, “Single-channel recording in myelinated nerve fibers reveals one type of Na channel but different K channels,” <i>PNAS</i>, vol. 86, no. 18. National Academy of Sciences, pp. 7238–7242, 1989.","ama":"Jonas PM, Bräu M, Hermsteiner M, Vogel W. Single-channel recording in myelinated nerve fibers reveals one type of Na channel but different K channels. <i>PNAS</i>. 1989;86(18):7238-7242. doi:<a href=\"https://doi.org/10.1073/pnas.86.18.7238\">10.1073/pnas.86.18.7238</a>","mla":"Jonas, Peter M., et al. “Single-Channel Recording in Myelinated Nerve Fibers Reveals One Type of Na Channel but Different K Channels.” <i>PNAS</i>, vol. 86, no. 18, National Academy of Sciences, 1989, pp. 7238–42, doi:<a href=\"https://doi.org/10.1073/pnas.86.18.7238\">10.1073/pnas.86.18.7238</a>.","short":"P.M. Jonas, M. Bräu, M. Hermsteiner, W. Vogel, PNAS 86 (1989) 7238–7242.","apa":"Jonas, P. M., Bräu, M., Hermsteiner, M., &#38; Vogel, W. (1989). Single-channel recording in myelinated nerve fibers reveals one type of Na channel but different K channels. <i>PNAS</i>. National Academy of Sciences. <a href=\"https://doi.org/10.1073/pnas.86.18.7238\">https://doi.org/10.1073/pnas.86.18.7238</a>","chicago":"Jonas, Peter M, Michael Bräu, Markus Hermsteiner, and Werner Vogel. “Single-Channel Recording in Myelinated Nerve Fibers Reveals One Type of Na Channel but Different K Channels.” <i>PNAS</i>. National Academy of Sciences, 1989. <a href=\"https://doi.org/10.1073/pnas.86.18.7238\">https://doi.org/10.1073/pnas.86.18.7238</a>.","ista":"Jonas PM, Bräu M, Hermsteiner M, Vogel W. 1989. Single-channel recording in myelinated nerve fibers reveals one type of Na channel but different K channels. PNAS. 86(18), 7238–7242."},"acknowledgement":"We thank Drs. C. Baumann, D. Siemen, and W. Stuhmer for reading the manuscript and Dr. F. Dreyer for the generous gift of DTX. The study was supported by the Deutsche Forschungsgemeinschaft.","article_processing_charge":"No","abstract":[{"text":"Amphibian myelinated nerve fibers were treated with collagenase and protease. Axons with retraction of the myelin sheath were patch-clamped in the nodal and paranodal region. One type of Na channel was found. It has a single-channel conductance of 11 pS (15 degrees C) and is blocked by tetrodotoxin. Averaged events show the typical activation and inactivation kinetics of macroscopic Na current. Three potential-dependent K channels were identified (I, F, and S channel). The I channel, being the most frequent type, has a single-channel conductance of 23 pS (inward current, 105 mM K on both sides of the membrane), activates between -60 and -30 mV, deactivates with intermediate kinetics, and is sensitive to dendrotoxin. The F channel has a conductance of 30 pS, activates between -40 and 60 mV, and deactivates with fast kinetics. The former inactivates within tens of seconds; the latter inactivates within seconds. The third type, the S channel, has a conductance of 7 pS and deactivates slowly. All three channels can be blocked by external tetraethylammonium chloride. We suggest that these distinct K channel types form the basis for the different components of macroscopic K current described previously.","lang":"eng"}],"publication_status":"published","publication":"PNAS","_id":"3466","author":[{"orcid":"0000-0001-5001-4804","full_name":"Jonas, Peter M","first_name":"Peter M","id":"353C1B58-F248-11E8-B48F-1D18A9856A87","last_name":"Jonas"},{"last_name":"Bräu","first_name":"Michael","full_name":"Bräu, Michael"},{"last_name":"Hermsteiner","full_name":"Hermsteiner, Markus","first_name":"Markus"},{"full_name":"Vogel, Werner","first_name":"Werner","last_name":"Vogel"}],"doi":"10.1073/pnas.86.18.7238","publication_identifier":{"issn":["0027-8424"],"eissn":["1091-6490"]},"extern":"1","type":"journal_article","date_updated":"2022-02-14T16:12:33Z","volume":86,"date_published":"1989-09-01T00:00:00Z","day":"01","publisher":"National Academy of Sciences","year":"1989","article_type":"original","pmid":1,"oa_version":"Published Version","issue":"18","quality_controlled":"1","title":"Single-channel recording in myelinated nerve fibers reveals one type of Na channel but different K channels","main_file_link":[{"url":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC298032/?tool=pubmed","open_access":"1"}],"language":[{"iso":"eng"}],"intvolume":"        86","publist_id":"2921"}