{"language":[{"iso":"eng"}],"_id":"3426","abstract":[{"lang":"eng","text":"We discuss the formation of graded morphogen profiles in a cell layer by nonlinear transport phenomena, important for patterning developing organisms. We focus on a process termed transcytosis, where morphogen transport results from the binding of ligands to receptors on the cell surface, incorporation into the cell, and subsequent externalization. Starting from a microscopic model, we derive effective transport equations. We show that, in contrast to morphogen transport by extracellular diffusion, transcytosis leads to robust ligand profiles which are insensitive to the rate of ligand production."}],"main_file_link":[{"open_access":"1","url":"http://arxiv.org/abs/q-bio/0412014"}],"publication_status":"published","extern":"1","citation":{"ama":"Bollenbach MT, Kruse K, Pantazis P, González Gaitán M, Jülicher F. Robust formation of morphogen gradients. <i>Physical Review Letters</i>. 2005;94(1). doi:<a href=\"https://doi.org/10.1103/PhysRevLett.94.018103\">10.1103/PhysRevLett.94.018103</a>","chicago":"Bollenbach, Mark Tobias, Karsten Kruse, Periklis Pantazis, Marcos González Gaitán, and Frank Jülicher. “Robust Formation of Morphogen Gradients.” <i>Physical Review Letters</i>. American Physical Society, 2005. <a href=\"https://doi.org/10.1103/PhysRevLett.94.018103\">https://doi.org/10.1103/PhysRevLett.94.018103</a>.","ista":"Bollenbach MT, Kruse K, Pantazis P, González Gaitán M, Jülicher F. 2005. Robust formation of morphogen gradients. Physical Review Letters. 94(1).","apa":"Bollenbach, M. T., Kruse, K., Pantazis, P., González Gaitán, M., &#38; Jülicher, F. (2005). Robust formation of morphogen gradients. <i>Physical Review Letters</i>. American Physical Society. <a href=\"https://doi.org/10.1103/PhysRevLett.94.018103\">https://doi.org/10.1103/PhysRevLett.94.018103</a>","short":"M.T. Bollenbach, K. Kruse, P. Pantazis, M. González Gaitán, F. Jülicher, Physical Review Letters 94 (2005).","mla":"Bollenbach, Mark Tobias, et al. “Robust Formation of Morphogen Gradients.” <i>Physical Review Letters</i>, vol. 94, no. 1, American Physical Society, 2005, doi:<a href=\"https://doi.org/10.1103/PhysRevLett.94.018103\">10.1103/PhysRevLett.94.018103</a>.","ieee":"M. T. Bollenbach, K. Kruse, P. Pantazis, M. González Gaitán, and F. Jülicher, “Robust formation of morphogen gradients,” <i>Physical Review Letters</i>, vol. 94, no. 1. American Physical Society, 2005."},"date_published":"2005-01-01T00:00:00Z","issue":"1","external_id":{"arxiv":["q-bio/0412014"]},"article_processing_charge":"No","month":"01","date_updated":"2021-01-12T07:43:23Z","type":"journal_article","doi":"10.1103/PhysRevLett.94.018103","publication":"Physical Review Letters","day":"01","author":[{"full_name":"Bollenbach, Mark Tobias","id":"3E6DB97A-F248-11E8-B48F-1D18A9856A87","first_name":"Mark Tobias","last_name":"Bollenbach","orcid":"0000-0003-4398-476X"},{"first_name":"Karsten","last_name":"Kruse","full_name":"Kruse, Karsten"},{"first_name":"Periklis","last_name":"Pantazis","full_name":"Pantazis, Periklis"},{"full_name":"González Gaitán, Marcos","last_name":"González Gaitán","first_name":"Marcos"},{"full_name":"Jülicher, Frank","first_name":"Frank","last_name":"Jülicher"}],"title":"Robust formation of morphogen gradients","status":"public","publisher":"American Physical Society","year":"2005","oa":1,"oa_version":"Preprint","intvolume":"        94","date_created":"2018-12-11T12:03:16Z","volume":94,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publist_id":"2975"}