{"_id":"3412","doi":"10.1146/annurev.biophys.36.040306.132640","author":[{"full_name":"Kedrov, Alexej","first_name":"Alexej","last_name":"Kedrov"},{"full_name":"Harald Janovjak","first_name":"Harald L","orcid":"0000-0002-8023-9315","last_name":"Janovjak","id":"33BA6C30-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Tanuj","full_name":"Sapra, Tanuj K","last_name":"Sapra"},{"last_name":"Mueller","first_name":"Daniel","full_name":"Mueller, Daniel J"}],"quality_controlled":0,"title":"Deciphering molecular interactions of native membrane proteins by single-molecule force spectroscopy","publication":"Annual Review of Biophysics","publication_status":"published","abstract":[{"lang":"eng","text":"Molecular interactions are the basic language of biological processes.\nThey establish the forces interacting between the building blocks of\nproteins and other macromolecules, thus determining their functional\nroles. Because molecular interactions trigger virtually every\nbiological process, approaches to decipher their language are needed.\nSingle-molecule force spectroscopy (SMFS) has been used to detect\nand characterize different types of molecular interactions that occur\nbetween and within native membrane proteins. The first experiments\ndetected and localized molecular interactions that stabilized\nmembrane proteins, including how these interactions were established\nduring folding of α-helical secondary structure elements into\nthe native protein and how they changed with oligomerization, temperature,\nand mutations. SMFS also enables investigators to detect\nand locate molecular interactions established during ligand and inhibitor\nbinding. These exciting applications provide opportunities\nfor studying the molecular forces of life. Further developments will\nelucidate the origins of molecular interactions encoded in their lifetimes,\ninteraction ranges, interplay, and dynamics characteristic of biological systems."}],"publist_id":"2989","date_updated":"2019-04-26T07:22:27Z","volume":36,"extern":1,"type":"review","intvolume":"        36","year":"2007","publisher":"Annual Reviews","status":"public","page":"233 - 260","day":"01","date_published":"2007-06-01T00:00:00Z","citation":{"apa":"Kedrov, A., Janovjak, H. L., Sapra, T., &#38; Mueller, D. (2007). Deciphering molecular interactions of native membrane proteins by single-molecule force spectroscopy. <i>Annual Review of Biophysics</i>. Annual Reviews. <a href=\"https://doi.org/10.1146/annurev.biophys.36.040306.132640\">https://doi.org/10.1146/annurev.biophys.36.040306.132640</a>","chicago":"Kedrov, Alexej, Harald L Janovjak, Tanuj Sapra, and Daniel Mueller. “Deciphering Molecular Interactions of Native Membrane Proteins by Single-Molecule Force Spectroscopy.” <i>Annual Review of Biophysics</i>. Annual Reviews, 2007. <a href=\"https://doi.org/10.1146/annurev.biophys.36.040306.132640\">https://doi.org/10.1146/annurev.biophys.36.040306.132640</a>.","ista":"Kedrov A, Janovjak HL, Sapra T, Mueller D. 2007. Deciphering molecular interactions of native membrane proteins by single-molecule force spectroscopy. Annual Review of Biophysics. 36, 233–260.","ieee":"A. Kedrov, H. L. Janovjak, T. Sapra, and D. Mueller, “Deciphering molecular interactions of native membrane proteins by single-molecule force spectroscopy,” <i>Annual Review of Biophysics</i>, vol. 36. Annual Reviews, pp. 233–260, 2007.","short":"A. Kedrov, H.L. Janovjak, T. Sapra, D. Mueller, Annual Review of Biophysics 36 (2007) 233–260.","ama":"Kedrov A, Janovjak HL, Sapra T, Mueller D. Deciphering molecular interactions of native membrane proteins by single-molecule force spectroscopy. <i>Annual Review of Biophysics</i>. 2007;36:233-260. doi:<a href=\"https://doi.org/10.1146/annurev.biophys.36.040306.132640\">10.1146/annurev.biophys.36.040306.132640</a>","mla":"Kedrov, Alexej, et al. “Deciphering Molecular Interactions of Native Membrane Proteins by Single-Molecule Force Spectroscopy.” <i>Annual Review of Biophysics</i>, vol. 36, Annual Reviews, 2007, pp. 233–60, doi:<a href=\"https://doi.org/10.1146/annurev.biophys.36.040306.132640\">10.1146/annurev.biophys.36.040306.132640</a>."},"month":"06","date_created":"2018-12-11T12:03:11Z"}