{"main_file_link":[{"open_access":"1","url":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3631701/"}],"abstract":[{"lang":"eng","text":"Parvalbumin is thought to act in a manner similar to EGTA, but how a slow Ca2+ buffer affects nanodomain-coupling regimes at GABAergic synapses is unclear. Direct measurements of parvalbumin concentration and paired recordings in rodent hippocampus and cerebellum revealed that parvalbumin affects synaptic dynamics only when expressed at high levels. Modeling suggests that, in high concentrations, parvalbumin may exert BAPTA-like effects, modulating nanodomain coupling via competition with local saturation of endogenous fixed buffers."}],"language":[{"iso":"eng"}],"department":[{"_id":"PeJo"}],"_id":"3318","citation":{"short":"E. Eggermann, P.M. Jonas, Nature Neuroscience 15 (2011) 20–22.","apa":"Eggermann, E., &#38; Jonas, P. M. (2011). How the “slow” Ca(2+) buffer parvalbumin affects transmitter release in nanodomain coupling regimes at GABAergic synapses. <i>Nature Neuroscience</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/nn.3002\">https://doi.org/10.1038/nn.3002</a>","chicago":"Eggermann, Emmanuel, and Peter M Jonas. “How the ‘Slow’ Ca(2+) Buffer Parvalbumin Affects Transmitter Release in Nanodomain Coupling Regimes at GABAergic Synapses.” <i>Nature Neuroscience</i>. Nature Publishing Group, 2011. <a href=\"https://doi.org/10.1038/nn.3002\">https://doi.org/10.1038/nn.3002</a>.","ista":"Eggermann E, Jonas PM. 2011. How the “slow” Ca(2+) buffer parvalbumin affects transmitter release in nanodomain coupling regimes at GABAergic synapses. Nature Neuroscience. 15, 20–22.","ama":"Eggermann E, Jonas PM. How the “slow” Ca(2+) buffer parvalbumin affects transmitter release in nanodomain coupling regimes at GABAergic synapses. <i>Nature Neuroscience</i>. 2011;15:20-22. doi:<a href=\"https://doi.org/10.1038/nn.3002\">10.1038/nn.3002</a>","ieee":"E. Eggermann and P. M. Jonas, “How the ‘slow’ Ca(2+) buffer parvalbumin affects transmitter release in nanodomain coupling regimes at GABAergic synapses,” <i>Nature Neuroscience</i>, vol. 15. Nature Publishing Group, pp. 20–22, 2011.","mla":"Eggermann, Emmanuel, and Peter M. Jonas. “How the ‘Slow’ Ca(2+) Buffer Parvalbumin Affects Transmitter Release in Nanodomain Coupling Regimes at GABAergic Synapses.” <i>Nature Neuroscience</i>, vol. 15, Nature Publishing Group, 2011, pp. 20–22, doi:<a href=\"https://doi.org/10.1038/nn.3002\">10.1038/nn.3002</a>."},"publication_status":"published","date_published":"2011-12-04T00:00:00Z","date_updated":"2021-01-12T07:42:37Z","month":"12","doi":"10.1038/nn.3002","page":"20 - 22","author":[{"full_name":"Eggermann, Emmanuel","first_name":"Emmanuel","last_name":"Eggermann"},{"orcid":"0000-0001-5001-4804","first_name":"Peter M","last_name":"Jonas","full_name":"Jonas, Peter M","id":"353C1B58-F248-11E8-B48F-1D18A9856A87"}],"publication":"Nature Neuroscience","day":"04","type":"journal_article","status":"public","title":"How the “slow” Ca(2+) buffer parvalbumin affects transmitter release in nanodomain coupling regimes at GABAergic synapses","quality_controlled":"1","scopus_import":1,"publisher":"Nature Publishing Group","year":"2011","volume":15,"user_id":"4435EBFC-F248-11E8-B48F-1D18A9856A87","publist_id":"3321","date_created":"2018-12-11T12:02:38Z","oa":1,"oa_version":"Submitted Version","intvolume":"        15"}