{"department":[{"_id":"PeJo"}],"main_file_link":[{"open_access":"1","url":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617474/"}],"abstract":[{"lang":"eng","text":"CA3 pyramidal neurons are important for memory formation and pattern completion in the hippocampal network. It is generally thought that proximal synapses from the mossy fibers activate these neurons most efficiently, whereas distal inputs from the perforant path have a weaker modulatory influence. We used confocally targeted patch-clamp recording from dendrites and axons to map the activation of rat CA3 pyramidal neurons at the subcellular level. Our results reveal two distinct dendritic domains. In the proximal domain, action potentials initiated in the axon backpropagate actively with large amplitude and fast time course. In the distal domain, Na+ channel–mediated dendritic spikes are efficiently initiated by waveforms mimicking synaptic events. CA3 pyramidal neuron dendrites showed a high Na+-to-K+ conductance density ratio, providing ideal conditions for active backpropagation and dendritic spike initiation. Dendritic spikes may enhance the computational power of CA3 pyramidal neurons in the hippocampal network."}],"date_published":"2012-04-01T00:00:00Z","publication_status":"published","issue":"4","month":"04","article_processing_charge":"No","pmid":1,"date_updated":"2023-09-07T11:43:52Z","type":"journal_article","day":"01","title":"Active dendrites support efficient initiation of dendritic spikes in hippocampal CA3 pyramidal neurons","quality_controlled":"1","status":"public","related_material":{"record":[{"status":"public","relation":"dissertation_contains","id":"2964"}]},"publisher":"Nature Publishing Group","scopus_import":"1","oa_version":"Published Version","oa":1,"user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","date_created":"2018-12-11T12:02:18Z","_id":"3258","language":[{"iso":"eng"}],"article_type":"original","citation":{"ama":"Kim S, Guzmán J, Hu H, Jonas PM. Active dendrites support efficient initiation of dendritic spikes in hippocampal CA3 pyramidal neurons. <i>Nature Neuroscience</i>. 2012;15(4):600-606. doi:<a href=\"https://doi.org/10.1038/nn.3060\">10.1038/nn.3060</a>","apa":"Kim, S., Guzmán, J., Hu, H., &#38; Jonas, P. M. (2012). Active dendrites support efficient initiation of dendritic spikes in hippocampal CA3 pyramidal neurons. <i>Nature Neuroscience</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/nn.3060\">https://doi.org/10.1038/nn.3060</a>","ista":"Kim S, Guzmán J, Hu H, Jonas PM. 2012. Active dendrites support efficient initiation of dendritic spikes in hippocampal CA3 pyramidal neurons. Nature Neuroscience. 15(4), 600–606.","chicago":"Kim, Sooyun, José Guzmán, Hua Hu, and Peter M Jonas. “Active Dendrites Support Efficient Initiation of Dendritic Spikes in Hippocampal CA3 Pyramidal Neurons.” <i>Nature Neuroscience</i>. Nature Publishing Group, 2012. <a href=\"https://doi.org/10.1038/nn.3060\">https://doi.org/10.1038/nn.3060</a>.","short":"S. Kim, J. Guzmán, H. Hu, P.M. Jonas, Nature Neuroscience 15 (2012) 600–606.","mla":"Kim, Sooyun, et al. “Active Dendrites Support Efficient Initiation of Dendritic Spikes in Hippocampal CA3 Pyramidal Neurons.” <i>Nature Neuroscience</i>, vol. 15, no. 4, Nature Publishing Group, 2012, pp. 600–06, doi:<a href=\"https://doi.org/10.1038/nn.3060\">10.1038/nn.3060</a>.","ieee":"S. Kim, J. Guzmán, H. Hu, and P. M. Jonas, “Active dendrites support efficient initiation of dendritic spikes in hippocampal CA3 pyramidal neurons,” <i>Nature Neuroscience</i>, vol. 15, no. 4. Nature Publishing Group, pp. 600–606, 2012."},"external_id":{"pmid":["22388958"]},"publication_identifier":{"issn":["1546-1726"]},"publication":"Nature Neuroscience","author":[{"last_name":"Kim","first_name":"Sooyun","full_name":"Kim, Sooyun","id":"394AB1C8-F248-11E8-B48F-1D18A9856A87"},{"orcid":"0000-0003-2209-5242","last_name":"Guzmán","first_name":"José","full_name":"Guzmán, José","id":"30CC5506-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Hua","last_name":"Hu","id":"4AC0145C-F248-11E8-B48F-1D18A9856A87","full_name":"Hu, Hua"},{"orcid":"0000-0001-5001-4804","full_name":"Jonas, Peter M","id":"353C1B58-F248-11E8-B48F-1D18A9856A87","first_name":"Peter M","last_name":"Jonas"}],"doi":"10.1038/nn.3060","page":"600 - 606","project":[{"name":"Glutamaterge synaptische Übertragung und Plastizität in hippocampalen Mikroschaltkreisen","_id":"25BDE9A4-B435-11E9-9278-68D0E5697425","grant_number":"SFB-TR3-TP10B"}],"acknowledgement":"This work was supported by the Deutsche Forschungsgemeinschaft (TR 3/B10) and the European Union (European Research Council Advanced grant to P.J.).","year":"2012","intvolume":"        15","publist_id":"3390","volume":15}