{"intvolume":"       109","publist_id":"3595","date_created":"2018-12-11T12:01:24Z","volume":109,"year":"2012","publisher":"National Academy of Sciences","title":"Transcription factor WRKY23 assists auxin distribution patterns during Arabidopsis root development through local control on flavonol biosynthesis","quality_controlled":0,"status":"public","type":"journal_article","day":"31","publication":"PNAS","author":[{"full_name":"Grunewald, Wim","last_name":"Grunewald","first_name":"Wim"},{"full_name":"De Smet, Ive","last_name":"De Smet","first_name":"Ive"},{"full_name":"Lewis, Daniel R","last_name":"Lewis","first_name":"Daniel"},{"full_name":"Löfke, Christian","last_name":"Löfke","first_name":"Christian"},{"last_name":"Jansen","first_name":"Leentje","full_name":"Jansen, Leentje"},{"full_name":"Goeminne, Geert","last_name":"Goeminne","first_name":"Geert"},{"first_name":"Robin","last_name":"Vanden Bossche","full_name":"Vanden Bossche, Robin"},{"last_name":"Karimi","first_name":"Mansour","full_name":"Karimi, Mansour"},{"last_name":"De Rybel","first_name":"Bert","full_name":"De Rybel, Bert"},{"last_name":"Vanholme","first_name":"Bartel","full_name":"Vanholme, Bartel"},{"first_name":"Thomas","last_name":"Teichmann","full_name":"Teichmann, Thomas"},{"last_name":"Boerjan","first_name":"Wout","full_name":"Boerjan, Wout"},{"full_name":"Van Montagu, Marc C","last_name":"Van Montagu","first_name":"Marc"},{"full_name":"Gheysen, Godelieve","last_name":"Gheysen","first_name":"Godelieve"},{"first_name":"Gloria","last_name":"Muday","full_name":"Muday, Gloria K"},{"orcid":"0000-0002-8302-7596","id":"4159519E-F248-11E8-B48F-1D18A9856A87","full_name":"Jirí Friml","first_name":"Jirí","last_name":"Friml"},{"full_name":"Beeckman, Tom","last_name":"Beeckman","first_name":"Tom"}],"doi":"10.1073/pnas.1121134109","page":"1554 - 1559","month":"01","date_updated":"2021-01-12T07:41:05Z","extern":1,"citation":{"mla":"Grunewald, Wim, et al. “Transcription Factor WRKY23 Assists Auxin Distribution Patterns during Arabidopsis Root Development through Local Control on Flavonol Biosynthesis.” <i>PNAS</i>, vol. 109, no. 5, National Academy of Sciences, 2012, pp. 1554–59, doi:<a href=\"https://doi.org/10.1073/pnas.1121134109\">10.1073/pnas.1121134109</a>.","ieee":"W. Grunewald <i>et al.</i>, “Transcription factor WRKY23 assists auxin distribution patterns during Arabidopsis root development through local control on flavonol biosynthesis,” <i>PNAS</i>, vol. 109, no. 5. National Academy of Sciences, pp. 1554–1559, 2012.","ama":"Grunewald W, De Smet I, Lewis D, et al. Transcription factor WRKY23 assists auxin distribution patterns during Arabidopsis root development through local control on flavonol biosynthesis. <i>PNAS</i>. 2012;109(5):1554-1559. doi:<a href=\"https://doi.org/10.1073/pnas.1121134109\">10.1073/pnas.1121134109</a>","chicago":"Grunewald, Wim, Ive De Smet, Daniel Lewis, Christian Löfke, Leentje Jansen, Geert Goeminne, Robin Vanden Bossche, et al. “Transcription Factor WRKY23 Assists Auxin Distribution Patterns during Arabidopsis Root Development through Local Control on Flavonol Biosynthesis.” <i>PNAS</i>. National Academy of Sciences, 2012. <a href=\"https://doi.org/10.1073/pnas.1121134109\">https://doi.org/10.1073/pnas.1121134109</a>.","ista":"Grunewald W, De Smet I, Lewis D, Löfke C, Jansen L, Goeminne G, Vanden Bossche R, Karimi M, De Rybel B, Vanholme B, Teichmann T, Boerjan W, Van Montagu M, Gheysen G, Muday G, Friml J, Beeckman T. 2012. Transcription factor WRKY23 assists auxin distribution patterns during Arabidopsis root development through local control on flavonol biosynthesis. PNAS. 109(5), 1554–1559.","apa":"Grunewald, W., De Smet, I., Lewis, D., Löfke, C., Jansen, L., Goeminne, G., … Beeckman, T. (2012). Transcription factor WRKY23 assists auxin distribution patterns during Arabidopsis root development through local control on flavonol biosynthesis. <i>PNAS</i>. National Academy of Sciences. <a href=\"https://doi.org/10.1073/pnas.1121134109\">https://doi.org/10.1073/pnas.1121134109</a>","short":"W. Grunewald, I. De Smet, D. Lewis, C. Löfke, L. Jansen, G. Goeminne, R. Vanden Bossche, M. Karimi, B. De Rybel, B. Vanholme, T. Teichmann, W. Boerjan, M. Van Montagu, G. Gheysen, G. Muday, J. Friml, T. Beeckman, PNAS 109 (2012) 1554–1559."},"date_published":"2012-01-31T00:00:00Z","publication_status":"published","issue":"5","_id":"3104","abstract":[{"text":"\nGradients of the plant hormone auxin, which depend on its active intercellular transport, are crucial for the maintenance of root meristematic activity. This directional transport is largely orchestrated by a complex interaction of specific influx and efflux carriers that mediate the auxin flow into and out of cells, respectively. Besides these transport proteins, plant-specific polyphenolic compounds knownasflavonols have beenshownto act as endogenous regulators of auxin transport. However, only limited information is available on how flavonol synthesis is developmentally regulated. Using reduction-of-function and overexpression approaches in parallel, we demonstrate that the WRKY23 transcription factor is needed for proper root growth and development by stimulating the local biosynthesis of flavonols. The expression of WRKY23 itself is controlled by auxin through the AUXIN RESPONSE FACTOR 7 (ARF7) and ARF19 transcriptional response pathway. Our results suggest a model in which WRKY23 is part of a transcriptional feedback loop of auxin on its own transport through local regulation of flavonol biosynthesis.","lang":"eng"}]}