{"project":[{"call_identifier":"FWF","name":"Control of Epithelial Cell Layer Spreading in Zebrafish","_id":"252ABD0A-B435-11E9-9278-68D0E5697425","grant_number":"I 930-B20"}],"year":"2012","acknowledged_ssus":[{"_id":"SSU"}],"intvolume":"       338","publist_id":"3778","volume":338,"language":[{"iso":"eng"}],"_id":"2950","citation":{"short":"M. Behrndt, G. Salbreux, P. Campinho, R. Hauschild, F. Oswald, J. Roensch, S. Grill, C.-P.J. Heisenberg, Science 338 (2012) 257–260.","ista":"Behrndt M, Salbreux G, Campinho P, Hauschild R, Oswald F, Roensch J, Grill S, Heisenberg C-PJ. 2012. Forces driving epithelial spreading in zebrafish gastrulation. Science. 338(6104), 257–260.","chicago":"Behrndt, Martin, Guillaume Salbreux, Pedro Campinho, Robert Hauschild, Felix Oswald, Julia Roensch, Stephan Grill, and Carl-Philipp J Heisenberg. “Forces Driving Epithelial Spreading in Zebrafish Gastrulation.” <i>Science</i>. American Association for the Advancement of Science, 2012. <a href=\"https://doi.org/10.1126/science.1224143\">https://doi.org/10.1126/science.1224143</a>.","apa":"Behrndt, M., Salbreux, G., Campinho, P., Hauschild, R., Oswald, F., Roensch, J., … Heisenberg, C.-P. J. (2012). Forces driving epithelial spreading in zebrafish gastrulation. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.1224143\">https://doi.org/10.1126/science.1224143</a>","ama":"Behrndt M, Salbreux G, Campinho P, et al. Forces driving epithelial spreading in zebrafish gastrulation. <i>Science</i>. 2012;338(6104):257-260. doi:<a href=\"https://doi.org/10.1126/science.1224143\">10.1126/science.1224143</a>","ieee":"M. Behrndt <i>et al.</i>, “Forces driving epithelial spreading in zebrafish gastrulation,” <i>Science</i>, vol. 338, no. 6104. American Association for the Advancement of Science, pp. 257–260, 2012.","mla":"Behrndt, Martin, et al. “Forces Driving Epithelial Spreading in Zebrafish Gastrulation.” <i>Science</i>, vol. 338, no. 6104, American Association for the Advancement of Science, 2012, pp. 257–60, doi:<a href=\"https://doi.org/10.1126/science.1224143\">10.1126/science.1224143</a>."},"doi":"10.1126/science.1224143","page":"257 - 260","publication":"Science","author":[{"full_name":"Behrndt, Martin","id":"3ECECA3A-F248-11E8-B48F-1D18A9856A87","last_name":"Behrndt","first_name":"Martin"},{"last_name":"Salbreux","first_name":"Guillaume","full_name":"Salbreux, Guillaume"},{"last_name":"Campinho","first_name":"Pedro","id":"3AFBBC42-F248-11E8-B48F-1D18A9856A87","full_name":"Campinho, Pedro","orcid":"0000-0002-8526-5416"},{"full_name":"Hauschild, Robert","id":"4E01D6B4-F248-11E8-B48F-1D18A9856A87","first_name":"Robert","last_name":"Hauschild","orcid":"0000-0001-9843-3522"},{"full_name":"Oswald, Felix","first_name":"Felix","last_name":"Oswald"},{"first_name":"Julia","last_name":"Roensch","full_name":"Roensch, Julia","id":"4220E59C-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Grill","first_name":"Stephan","full_name":"Grill, Stephan"},{"orcid":"0000-0002-0912-4566","full_name":"Heisenberg, Carl-Philipp J","id":"39427864-F248-11E8-B48F-1D18A9856A87","first_name":"Carl-Philipp J","last_name":"Heisenberg"}],"title":"Forces driving epithelial spreading in zebrafish gastrulation","quality_controlled":"1","related_material":{"record":[{"status":"public","id":"1403","relation":"dissertation_contains"}]},"status":"public","publisher":"American Association for the Advancement of Science","scopus_import":1,"oa_version":"None","user_id":"4435EBFC-F248-11E8-B48F-1D18A9856A87","date_created":"2018-12-11T12:00:30Z","department":[{"_id":"CaHe"},{"_id":"Bio"}],"abstract":[{"text":"Contractile actomyosin rings drive various fundamental morphogenetic processes ranging from cytokinesis to wound healing. Actomyosin rings are generally thought to function by circumferential contraction. Here, we show that the spreading of the enveloping cell layer (EVL) over the yolk cell during zebrafish gastrulation is driven by a contractile actomyosin ring. In contrast to previous suggestions, we find that this ring functions not only by circumferential contraction but also by a flow-friction mechanism. This generates a pulling force through resistance against retrograde actomyosin flow. EVL spreading proceeds normally in situations where circumferential contraction is unproductive, indicating that the flow-friction mechanism is sufficient. Thus, actomyosin rings can function in epithelial morphogenesis through a combination of cable-constriction and flow-friction mechanisms.","lang":"eng"}],"publication_status":"published","date_published":"2012-10-12T00:00:00Z","issue":"6104","month":"10","date_updated":"2023-02-21T17:02:44Z","type":"journal_article","day":"12"}