{"status":"public","title":"Cell type dependence and variability in the short-term plasticity of EPSCs in identified mouse hippocampal interneurones","quality_controlled":0,"year":"2002","publisher":"Wiley-Blackwell","volume":542,"date_created":"2018-12-11T11:58:42Z","publist_id":"4281","intvolume":"       542","oa":1,"abstract":[{"lang":"eng","text":"Synapses exhibit different short-term plasticity patterns and this behaviour influences information processing in neuronal networks. We tested how the short-term plasticity of excitatory postsynaptic currents (EPSCs) depends on the postsynaptic cell type, identified by axonal arborizations and molecular markers in the hippocampal CA1 area. Three distinct types of short-term synaptic behaviour (facilitating, depressing and combined facilitating-depressing) were defined by fitting a dynamic neurotransmission model to the data. Approximately 75 % of the oriens-lacunosum-moleculare (O-LM) interneurones received facilitating EPSCs, but in three of 12 O-LM cells EPSCs also showed significant depression. Over 90 % of the O-LM cells were immunopositive for somatostatin and mGluR1α and all tested cells were decorated by strongly mGluR7a positive axon terminals. Responses in eight of 12 basket cells were described well with a model involving only depression, but the other cells displayed combined facilitating-depressing EPSCs. No apparent difference was found between the plasticity of EPSCs in cholecystokinin- or parvalbumin-containing basket cells. In oriens-bistratified cells (O-Bi), two of nine cells showed facilitating EPSCs, another two depressing, and the remaining five cells combined facilitating-depressing EPSCs. Seven of 10 cells tested for somatostatin were immunopositive, but mGluR1α was detectable only in two of 11 tested cells. Furthermore, most O-Bi cells projected to the CA3 area and the subiculum, as well as outside the hippocampal formation. Postsynaptic responses to action potentials recorded in vivo from a CA1 place cell were modelled, and revealed great differences between and within cell types. Our results demonstrate that the short-term plasticity of EPSCs is cell type dependent, but with significant heterogeneity within all three interneurone populations."}],"main_file_link":[{"open_access":"1","url":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2290398/"}],"_id":"2617","issue":"1","extern":1,"publication_status":"published","date_published":"2002-07-01T00:00:00Z","citation":{"mla":"Losonczy, Attila, et al. “Cell Type Dependence and Variability in the Short-Term Plasticity of EPSCs in Identified Mouse Hippocampal Interneurones.” <i>Journal of Physiology</i>, vol. 542, no. 1, Wiley-Blackwell, 2002, pp. 193–210, doi:<a href=\"https://doi.org/10.1113/jphysiol.2002.020024\">10.1113/jphysiol.2002.020024</a>.","ieee":"A. Losonczy, L. Zhang, R. Shigemoto, P. Somogyi, and Z. Nusser, “Cell type dependence and variability in the short-term plasticity of EPSCs in identified mouse hippocampal interneurones,” <i>Journal of Physiology</i>, vol. 542, no. 1. Wiley-Blackwell, pp. 193–210, 2002.","chicago":"Losonczy, Attila, Limei Zhang, Ryuichi Shigemoto, Péter Somogyi, and Zoltán Nusser. “Cell Type Dependence and Variability in the Short-Term Plasticity of EPSCs in Identified Mouse Hippocampal Interneurones.” <i>Journal of Physiology</i>. Wiley-Blackwell, 2002. <a href=\"https://doi.org/10.1113/jphysiol.2002.020024\">https://doi.org/10.1113/jphysiol.2002.020024</a>.","ista":"Losonczy A, Zhang L, Shigemoto R, Somogyi P, Nusser Z. 2002. Cell type dependence and variability in the short-term plasticity of EPSCs in identified mouse hippocampal interneurones. Journal of Physiology. 542(1), 193–210.","apa":"Losonczy, A., Zhang, L., Shigemoto, R., Somogyi, P., &#38; Nusser, Z. (2002). Cell type dependence and variability in the short-term plasticity of EPSCs in identified mouse hippocampal interneurones. <i>Journal of Physiology</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1113/jphysiol.2002.020024\">https://doi.org/10.1113/jphysiol.2002.020024</a>","ama":"Losonczy A, Zhang L, Shigemoto R, Somogyi P, Nusser Z. Cell type dependence and variability in the short-term plasticity of EPSCs in identified mouse hippocampal interneurones. <i>Journal of Physiology</i>. 2002;542(1):193-210. doi:<a href=\"https://doi.org/10.1113/jphysiol.2002.020024\">10.1113/jphysiol.2002.020024</a>","short":"A. Losonczy, L. Zhang, R. Shigemoto, P. Somogyi, Z. Nusser, Journal of Physiology 542 (2002) 193–210."},"date_updated":"2021-01-12T06:58:36Z","month":"07","author":[{"full_name":"Losonczy, Attila","first_name":"Attila","last_name":"Losonczy"},{"full_name":"Zhang, Limei","last_name":"Zhang","first_name":"Limei"},{"orcid":"0000-0001-8761-9444","last_name":"Shigemoto","first_name":"Ryuichi","full_name":"Ryuichi Shigemoto","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Somogyi, Péter","first_name":"Péter","last_name":"Somogyi"},{"full_name":"Nusser, Zoltán","last_name":"Nusser","first_name":"Zoltán"}],"day":"01","publication":"Journal of Physiology","page":"193 - 210","doi":"10.1113/jphysiol.2002.020024","type":"journal_article"}