{"oa_version":"None","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","date_created":"2018-12-11T11:58:28Z","publisher":"Wiley-Blackwell","scopus_import":"1","title":"Distribution of trigeminohypothalamic and spinohypothalamic tract neurons displaying substance P receptor-like immunoreactivity in the rat","quality_controlled":"1","status":"public","type":"journal_article","day":"24","month":"02","article_processing_charge":"No","date_updated":"2022-08-22T13:34:53Z","pmid":1,"publication_status":"published","date_published":"1997-02-24T00:00:00Z","extern":"1","issue":"4","abstract":[{"text":"Primary afferent neurons containing substance P (SP) are apparently implicated in the transmission of noxious information from the periphery to the central nervous system, and SP released from primary afferent neurons acts on second-order neurons with the SP receptor (SPR). In the rat, nociceptive information reached the hypothalamus not only through indirect pathways but also directly through trigeminohypothalamic and spinohypothalamic pathways. Thus, in the present study, the distribution pattern of trigeminohypothalamic and spinohypothalamic tract neurons showing SPR-like immunoreactivity (SPR-LI) was examined in the rat by a retrograde tract-tracing method combined with immunofluorescence histochemistry for SPR. A substantial number of trigeminal and spinal neurons with SPR-LI were retrogradely labeled with Fluore-Gold (FG) injected into the hypothalamic regions. These neurons were distributed mainly in lamina I of the medullary and spinal dorsal horns, lateral spinal nucleus, regions around the central canal of the spinal cord, and the lateral aspect of the deep part of the spinal dorsal horn. A number of SPR-LI neurons in the spinal parasympathetic nucleus were labeled with FG injected into the area around the paraventricular hypothalamic nucleus. Some SPR-LI neurons in the lateral spinal nucleus and the lateral aspect of the deep part of the spinal dorsal horn were also labeled with FG injected into the septal region. On the basis of the distribution areas of SPR-LI trigeminal and spinal neurons projecting to the hypothalamic and septal regions, it is likely that these neurons are involved in the transmission of somatic and/or visceral noxious information.","lang":"eng"}],"intvolume":" 378","volume":378,"publist_id":"4323","year":"1997","acknowledgement":"This study was supported by grants 08279106 and 08458245 from the Ministry of Education, Science, Sportsand Culture of Japan. We are grateful for the photographic help of Mr. Akira Uesugi and the support of Dr. Kajitaro Morita in Morita Clinic of Internal Medicine and Pediatrics, Kadoma, Osaka, Japan. We also express our gratitude for the support of Drs. Satoru Fukuchi, Ritsu Hayashi,Sohzaburo Hayashi, Mizuho Katsurada, Hitoski Kawai,Yutaka Kitani, Toshihiko Kuroda, Keiko Kumagai, Hiroshi Matsubara, Hiroshi Matsushima, Chisato Minakuchi,Gonpei Niwa, Hajime Oda, Mashiko Ohbayashi, Seiichi Ohbayashi, Hiroyasu Ohtsuka, Shigeo Tamaki, EizoWatanabe, Kazuo Yoshino, and Toshiaki Yoshino.","author":[{"full_name":"Li, Jin","last_name":"Li","first_name":"Jin"},{"full_name":"Kaneko, Takeshi","last_name":"Kaneko","first_name":"Takeshi"},{"orcid":"0000-0001-8761-9444","last_name":"Shigemoto","first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","full_name":"Shigemoto, Ryuichi"},{"full_name":"Mizuno, Noboru","first_name":"Noboru","last_name":"Mizuno"}],"publication":"Journal of Comparative Neurology","doi":"10.1002/(SICI)1096-9861(19970224)378:4<508::AID-CNE6>3.0.CO;2-6","page":"508 - 521","external_id":{"pmid":["9034907"]},"publication_identifier":{"issn":["0021-9967"]},"citation":{"mla":"Li, Jin, et al. “Distribution of Trigeminohypothalamic and Spinohypothalamic Tract Neurons Displaying Substance P Receptor-like Immunoreactivity in the Rat.” Journal of Comparative Neurology, vol. 378, no. 4, Wiley-Blackwell, 1997, pp. 508–21, doi:10.1002/(SICI)1096-9861(19970224)378:4<508::AID-CNE6>3.0.CO;2-6.","ieee":"J. Li, T. Kaneko, R. Shigemoto, and N. Mizuno, “Distribution of trigeminohypothalamic and spinohypothalamic tract neurons displaying substance P receptor-like immunoreactivity in the rat,” Journal of Comparative Neurology, vol. 378, no. 4. Wiley-Blackwell, pp. 508–521, 1997.","chicago":"Li, Jin, Takeshi Kaneko, Ryuichi Shigemoto, and Noboru Mizuno. “Distribution of Trigeminohypothalamic and Spinohypothalamic Tract Neurons Displaying Substance P Receptor-like Immunoreactivity in the Rat.” Journal of Comparative Neurology. Wiley-Blackwell, 1997. https://doi.org/10.1002/(SICI)1096-9861(19970224)378:4<508::AID-CNE6>3.0.CO;2-6.","ista":"Li J, Kaneko T, Shigemoto R, Mizuno N. 1997. Distribution of trigeminohypothalamic and spinohypothalamic tract neurons displaying substance P receptor-like immunoreactivity in the rat. Journal of Comparative Neurology. 378(4), 508–521.","apa":"Li, J., Kaneko, T., Shigemoto, R., & Mizuno, N. (1997). Distribution of trigeminohypothalamic and spinohypothalamic tract neurons displaying substance P receptor-like immunoreactivity in the rat. Journal of Comparative Neurology. Wiley-Blackwell. https://doi.org/10.1002/(SICI)1096-9861(19970224)378:4<508::AID-CNE6>3.0.CO;2-6","ama":"Li J, Kaneko T, Shigemoto R, Mizuno N. Distribution of trigeminohypothalamic and spinohypothalamic tract neurons displaying substance P receptor-like immunoreactivity in the rat. Journal of Comparative Neurology. 1997;378(4):508-521. doi:10.1002/(SICI)1096-9861(19970224)378:4<508::AID-CNE6>3.0.CO;2-6","short":"J. Li, T. Kaneko, R. Shigemoto, N. Mizuno, Journal of Comparative Neurology 378 (1997) 508–521."},"article_type":"original","_id":"2576","language":[{"iso":"eng"}]}