{"oa_version":"None","date_created":"2018-12-11T11:58:28Z","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publisher":"Elsevier","scopus_import":"1","title":"Localization of a metabotropic glutamate receptor, mGluR7, in axon terminals of presumed nociceptive, primary afferent fibers in the superficial layers of the spinal dorsal horn: An electron microscope study in the rat","quality_controlled":"1","status":"public","type":"journal_article","day":"28","article_processing_charge":"No","month":"02","date_updated":"2022-08-22T13:06:30Z","pmid":1,"extern":"1","publication_status":"published","date_published":"1997-02-28T00:00:00Z","issue":"3","abstract":[{"text":"It was examined electron microscopically in the rat if a metabotropic glutamate receptor, mGluR7, might be localized in axon terminals of nociceptive, primary afferent fibers in laminae I and II of the spinal dorsal horn. Nociceptive nature of axon terminals showing mGluR7-like immunoreactivity (mGluR7-LI) was indicated by binding to the isolectin I-B4 from Griffonia simplicifolia (I-B4), or by substance P-like immunoreactivity (SP-LI). Axon terminals labeled with immunogold particles indicating mGluR7-LI were usually filled with round synaptic vesicles and were in asymmetric synaptic contact with dendritic or somatic profiles; occasionally they contained pleomorphic vesicles and were in symmetric synaptic contact with somatic profiles in lamina II. The double-labeling studies revealed that most of axon terminals with I-B4 labeling as well as a small population of axon terminals with SP-LI, showed mGluR7-LI. About one-third or much smaller population of axon terminals with mGluR7-LI in laminae I and II were labeled, respectively, with I-B4 or SP-LI; these were in asymmetric synaptic contact with dendritic profiles.","lang":"eng"}],"intvolume":"       223","publist_id":"4322","volume":223,"year":"1997","acknowledgement":"We are grateful for photographic help of Mr. Akira Uesugi. We also express our gratitude for the support of Drs. Satoru Fukuchi, Ritsu Hayashi, Sohzaburo Hayashi, Mizuho Katsurada, Hitoshi Kawai, Yutaka Kitani, Toshihiko Kuroda, Keiko Kumagai, Hiroshi Matsubara, Hiroshi Matsushima, Chisato Minakuchi, Gonpei Niwa, Hajime Oda, Masahiko Ohbayashi, Sei-ichi Ohbayashi, Hiroyasu Ohtsuka, Shigeo Tamaki, Eizo Watanabe, Kazuo Yoshino, and Toshiaki Yoshino. This work was supported in part by Grant-in-Aid from Ministry of Education, Science, Culture and Sports of Japan.","publication":"Neuroscience Letters","author":[{"first_name":"He","last_name":"Li","full_name":"Li, He"},{"full_name":"Ohishi, Hitoshi","first_name":"Hitoshi","last_name":"Ohishi"},{"first_name":"Ayae","last_name":"Kinoshita","full_name":"Kinoshita, Ayae"},{"orcid":"0000-0001-8761-9444","first_name":"Ryuichi","last_name":"Shigemoto","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","full_name":"Shigemoto, Ryuichi"},{"full_name":"Nomura, Sakashi","last_name":"Nomura","first_name":"Sakashi"},{"last_name":"Mizuno","first_name":"Noboru","full_name":"Mizuno, Noboru"}],"page":"153 - 156","doi":"10.1016/S0304-3940(97)13429-2","external_id":{"pmid":["9080455"]},"publication_identifier":{"issn":["0304-3940"]},"citation":{"short":"H. Li, H. Ohishi, A. Kinoshita, R. Shigemoto, S. Nomura, N. Mizuno, Neuroscience Letters 223 (1997) 153–156.","chicago":"Li, He, Hitoshi Ohishi, Ayae Kinoshita, Ryuichi Shigemoto, Sakashi Nomura, and Noboru Mizuno. “Localization of a Metabotropic Glutamate Receptor, MGluR7, in Axon Terminals of Presumed Nociceptive, Primary Afferent Fibers in the Superficial Layers of the Spinal Dorsal Horn: An Electron Microscope Study in the Rat.” <i>Neuroscience Letters</i>. Elsevier, 1997. <a href=\"https://doi.org/10.1016/S0304-3940(97)13429-2\">https://doi.org/10.1016/S0304-3940(97)13429-2</a>.","ista":"Li H, Ohishi H, Kinoshita A, Shigemoto R, Nomura S, Mizuno N. 1997. Localization of a metabotropic glutamate receptor, mGluR7, in axon terminals of presumed nociceptive, primary afferent fibers in the superficial layers of the spinal dorsal horn: An electron microscope study in the rat. Neuroscience Letters. 223(3), 153–156.","apa":"Li, H., Ohishi, H., Kinoshita, A., Shigemoto, R., Nomura, S., &#38; Mizuno, N. (1997). Localization of a metabotropic glutamate receptor, mGluR7, in axon terminals of presumed nociceptive, primary afferent fibers in the superficial layers of the spinal dorsal horn: An electron microscope study in the rat. <i>Neuroscience Letters</i>. Elsevier. <a href=\"https://doi.org/10.1016/S0304-3940(97)13429-2\">https://doi.org/10.1016/S0304-3940(97)13429-2</a>","ama":"Li H, Ohishi H, Kinoshita A, Shigemoto R, Nomura S, Mizuno N. Localization of a metabotropic glutamate receptor, mGluR7, in axon terminals of presumed nociceptive, primary afferent fibers in the superficial layers of the spinal dorsal horn: An electron microscope study in the rat. <i>Neuroscience Letters</i>. 1997;223(3):153-156. doi:<a href=\"https://doi.org/10.1016/S0304-3940(97)13429-2\">10.1016/S0304-3940(97)13429-2</a>","ieee":"H. Li, H. Ohishi, A. Kinoshita, R. Shigemoto, S. Nomura, and N. Mizuno, “Localization of a metabotropic glutamate receptor, mGluR7, in axon terminals of presumed nociceptive, primary afferent fibers in the superficial layers of the spinal dorsal horn: An electron microscope study in the rat,” <i>Neuroscience Letters</i>, vol. 223, no. 3. Elsevier, pp. 153–156, 1997.","mla":"Li, He, et al. “Localization of a Metabotropic Glutamate Receptor, MGluR7, in Axon Terminals of Presumed Nociceptive, Primary Afferent Fibers in the Superficial Layers of the Spinal Dorsal Horn: An Electron Microscope Study in the Rat.” <i>Neuroscience Letters</i>, vol. 223, no. 3, Elsevier, 1997, pp. 153–56, doi:<a href=\"https://doi.org/10.1016/S0304-3940(97)13429-2\">10.1016/S0304-3940(97)13429-2</a>."},"article_type":"original","_id":"2575","language":[{"iso":"eng"}]}