{"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","date_created":"2018-12-11T11:58:23Z","oa":1,"oa_version":"Published Version","publisher":"Cell Press","status":"public","title":"Specific deficit of the ON response in visual transmission by targeted disruption of the mGIuR6 gene","quality_controlled":"1","day":"10","type":"journal_article","pmid":1,"date_updated":"2022-06-28T13:27:50Z","month":"02","article_processing_charge":"No","issue":"5","publication_status":"published","date_published":"1995-02-10T00:00:00Z","extern":"1","main_file_link":[{"url":"https://www.sciencedirect.com/science/article/pii/0092867495903542","open_access":"1"}],"abstract":[{"lang":"eng","text":"Taking advantage of the restricted expression of metabotropic glutamate receptor subtype 6 (mGIuR6) in retinal ON bipolar cells, we generated knockout mice lacking mGIuR6 expression. The homozygous mutant mice showed a loss of ON responses but unchanged OFF responses to light. The mutant mice displayed no obvious changes in retinal cell organization nor in the projection of optic fibers to the brain. Furthermore, the mGIuR6-deficient mice showed visual behavioral responses to light stimulation as examined by shuttle box avoidance behavior experiments using light exposure as a conditioned stimulus. The results demonstrate that mGIuR6 is essential in synaptic transmission to the ON bipolar cell and that the OFF response provides an important means for transmitting visual information."}],"publist_id":"4339","volume":80,"intvolume":"        80","year":"1995","acknowledgement":"We thank Drs. N. Mizuno, M. Iso, M. Tachibana, A. Kaneko, M. Tessier-Lavigne, and T. Hensch for useful advice and A. Uesugi for photographic assistance. This work is supported by grants in aid for specially promoted research, for scientific research on priority areas, and for scientific research (A) from the Ministry of Education, Science, and Culture in Japan and by grants from the Ministry of Health and Welfare of Japan, the Sankyo Foundation, and the Senri Life Science Foundation.","page":"757 - 765","doi":"10.1016/0092-8674(95)90354-2","publication":"Cell","author":[{"full_name":"Masu, Masayuki","last_name":"Masu","first_name":"Masayuki"},{"full_name":"Iwakabe, Hideki","last_name":"Iwakabe","first_name":"Hideki"},{"full_name":"Tagawa, Yoshiaki","last_name":"Tagawa","first_name":"Yoshiaki"},{"full_name":"Miyoshi, Tomomitsu","first_name":"Tomomitsu","last_name":"Miyoshi"},{"first_name":"Masayuki","last_name":"Yamashita","full_name":"Yamashita, Masayuki"},{"last_name":"Fukuda","first_name":"Yutaka","full_name":"Fukuda, Yutaka"},{"full_name":"Sasaki, Hitoshi","first_name":"Hitoshi","last_name":"Sasaki"},{"full_name":"Hiroi, Kano","last_name":"Hiroi","first_name":"Kano"},{"full_name":"Nakamura, Yasuhisa","first_name":"Yasuhisa","last_name":"Nakamura"},{"orcid":"0000-0001-8761-9444","first_name":"Ryuichi","last_name":"Shigemoto","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","full_name":"Shigemoto, Ryuichi"},{"full_name":"Takada, Masahiko","first_name":"Masahiko","last_name":"Takada"},{"full_name":"Nakamura, Kenji","first_name":"Kenji","last_name":"Nakamura"},{"first_name":"Kazuki","last_name":"Nakao","full_name":"Nakao, Kazuki"},{"first_name":"Motoya","last_name":"Katsuki","full_name":"Katsuki, Motoya"},{"last_name":"Nakanishi","first_name":"Shigetada","full_name":"Nakanishi, Shigetada"}],"publication_identifier":{"issn":["0092-8674"]},"external_id":{"pmid":["7889569"]},"citation":{"chicago":"Masu, Masayuki, Hideki Iwakabe, Yoshiaki Tagawa, Tomomitsu Miyoshi, Masayuki Yamashita, Yutaka Fukuda, Hitoshi Sasaki, et al. “Specific Deficit of the ON Response in Visual Transmission by Targeted Disruption of the MGIuR6 Gene.” <i>Cell</i>. Cell Press, 1995. <a href=\"https://doi.org/10.1016/0092-8674(95)90354-2\">https://doi.org/10.1016/0092-8674(95)90354-2</a>.","apa":"Masu, M., Iwakabe, H., Tagawa, Y., Miyoshi, T., Yamashita, M., Fukuda, Y., … Nakanishi, S. (1995). Specific deficit of the ON response in visual transmission by targeted disruption of the mGIuR6 gene. <i>Cell</i>. Cell Press. <a href=\"https://doi.org/10.1016/0092-8674(95)90354-2\">https://doi.org/10.1016/0092-8674(95)90354-2</a>","ista":"Masu M, Iwakabe H, Tagawa Y, Miyoshi T, Yamashita M, Fukuda Y, Sasaki H, Hiroi K, Nakamura Y, Shigemoto R, Takada M, Nakamura K, Nakao K, Katsuki M, Nakanishi S. 1995. Specific deficit of the ON response in visual transmission by targeted disruption of the mGIuR6 gene. Cell. 80(5), 757–765.","ama":"Masu M, Iwakabe H, Tagawa Y, et al. Specific deficit of the ON response in visual transmission by targeted disruption of the mGIuR6 gene. <i>Cell</i>. 1995;80(5):757-765. doi:<a href=\"https://doi.org/10.1016/0092-8674(95)90354-2\">10.1016/0092-8674(95)90354-2</a>","short":"M. Masu, H. Iwakabe, Y. Tagawa, T. Miyoshi, M. Yamashita, Y. Fukuda, H. Sasaki, K. Hiroi, Y. Nakamura, R. Shigemoto, M. Takada, K. Nakamura, K. Nakao, M. Katsuki, S. Nakanishi, Cell 80 (1995) 757–765.","mla":"Masu, Masayuki, et al. “Specific Deficit of the ON Response in Visual Transmission by Targeted Disruption of the MGIuR6 Gene.” <i>Cell</i>, vol. 80, no. 5, Cell Press, 1995, pp. 757–65, doi:<a href=\"https://doi.org/10.1016/0092-8674(95)90354-2\">10.1016/0092-8674(95)90354-2</a>.","ieee":"M. Masu <i>et al.</i>, “Specific deficit of the ON response in visual transmission by targeted disruption of the mGIuR6 gene,” <i>Cell</i>, vol. 80, no. 5. Cell Press, pp. 757–765, 1995."},"article_type":"original","language":[{"iso":"eng"}],"_id":"2559"}