{"type":"journal_article","day":"02","month":"08","article_processing_charge":"No","date_updated":"2022-02-08T13:52:37Z","pmid":1,"extern":"1","publication_status":"published","date_published":"1988-08-02T00:00:00Z","issue":"1","abstract":[{"lang":"eng","text":"Alpha-ketoglutamate (α-KG) reductive amination activity in rat brain was found to be mostly absorbed with an antibody against liver glutamate dehydrogenase. With this and anti-glutamine synthetase antibodies, α-KG reductive amination activity was immunocytochemically shown to coexist with glutamine synthetase activity in astrocytes. The results suggest that astrocytes de novo synthesize glutamate from α-KG and ammonia, and metabolize it to glutamine."}],"main_file_link":[{"url":"https://www.sciencedirect.com/science/article/pii/0006899388900698?via%3Dihub"}],"oa_version":"None","date_created":"2018-12-11T11:58:11Z","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publisher":"Elsevier","scopus_import":"1","title":"Metabolism of glutamate and ammonia in astrocyte an immunocytochemical study","quality_controlled":"1","status":"public","publication":"Brain Research","author":[{"first_name":"Takeshi","last_name":"Kaneko","full_name":"Kaneko, Takeshi"},{"orcid":"0000-0001-8761-9444","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","full_name":"Shigemoto, Ryuichi","first_name":"Ryuichi","last_name":"Shigemoto"},{"first_name":"Noboru","last_name":"Mizuno","full_name":"Mizuno, Noboru"}],"doi":"10.1016/0006-8993(88)90069-8","page":"160 - 164","external_id":{"pmid":["3167561"]},"publication_identifier":{"issn":["0006-8993"],"eissn":["1872-6240"]},"citation":{"ama":"Kaneko T, Shigemoto R, Mizuno N. Metabolism of glutamate and ammonia in astrocyte an immunocytochemical study. <i>Brain Research</i>. 1988;457(1):160-164. doi:<a href=\"https://doi.org/10.1016/0006-8993(88)90069-8\">10.1016/0006-8993(88)90069-8</a>","apa":"Kaneko, T., Shigemoto, R., &#38; Mizuno, N. (1988). Metabolism of glutamate and ammonia in astrocyte an immunocytochemical study. <i>Brain Research</i>. Elsevier. <a href=\"https://doi.org/10.1016/0006-8993(88)90069-8\">https://doi.org/10.1016/0006-8993(88)90069-8</a>","chicago":"Kaneko, Takeshi, Ryuichi Shigemoto, and Noboru Mizuno. “Metabolism of Glutamate and Ammonia in Astrocyte an Immunocytochemical Study.” <i>Brain Research</i>. Elsevier, 1988. <a href=\"https://doi.org/10.1016/0006-8993(88)90069-8\">https://doi.org/10.1016/0006-8993(88)90069-8</a>.","ista":"Kaneko T, Shigemoto R, Mizuno N. 1988. Metabolism of glutamate and ammonia in astrocyte an immunocytochemical study. Brain Research. 457(1), 160–164.","short":"T. Kaneko, R. Shigemoto, N. Mizuno, Brain Research 457 (1988) 160–164.","mla":"Kaneko, Takeshi, et al. “Metabolism of Glutamate and Ammonia in Astrocyte an Immunocytochemical Study.” <i>Brain Research</i>, vol. 457, no. 1, Elsevier, 1988, pp. 160–64, doi:<a href=\"https://doi.org/10.1016/0006-8993(88)90069-8\">10.1016/0006-8993(88)90069-8</a>.","ieee":"T. Kaneko, R. Shigemoto, and N. Mizuno, “Metabolism of glutamate and ammonia in astrocyte an immunocytochemical study,” <i>Brain Research</i>, vol. 457, no. 1. Elsevier, pp. 160–164, 1988."},"article_type":"original","_id":"2524","language":[{"iso":"eng"}],"intvolume":"       457","volume":457,"publist_id":"4375","year":"1988","acknowledgement":"The authors are grateful to Akira Uesugi and Ken’ichi Uesugi for photographic help. This work was supported by the Niwa Medical Research Foundation and Grants-in-Aid for Special -Project Research (62121004), for General Scientific Research (62480098) and for Encouragement of Young Scientists (63770043) from the Ministry of Education, Science and Culture of Japan. "}