{"status":"public","quality_controlled":0,"title":"Metabotropic glutamate receptor 4-immunopositive terminals of medium-sized spiny neurons selectively form synapses with cholinergic interneurons in the rat neostriatum","volume":500,"date_created":"2018-12-11T11:58:00Z","publist_id":"4406","intvolume":"       500","year":"2007","publisher":"Wiley-Blackwell","issue":"5","extern":1,"citation":{"apa":"Kuramoto, E., Fujiyama, F., Unzai, T., Nakamura, K., Hioki, H., Furuta, T., … Kaneko, T. (2007). Metabotropic glutamate receptor 4-immunopositive terminals of medium-sized spiny neurons selectively form synapses with cholinergic interneurons in the rat neostriatum. <i>Journal of Comparative Neurology</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1002/cne.21216\">https://doi.org/10.1002/cne.21216</a>","ista":"Kuramoto E, Fujiyama F, Unzai T, Nakamura K, Hioki H, Furuta T, Shigemoto R, Ferraguti F, Kaneko T. 2007. Metabotropic glutamate receptor 4-immunopositive terminals of medium-sized spiny neurons selectively form synapses with cholinergic interneurons in the rat neostriatum. Journal of Comparative Neurology. 500(5), 908–922.","chicago":"Kuramoto, Eriko, Fumino Fujiyama, Tomo Unzai, Kouichi Nakamura, Hiroyuki Hioki, Takahiro Furuta, Ryuichi Shigemoto, Francesco Ferraguti, and Takeshi Kaneko. “Metabotropic Glutamate Receptor 4-Immunopositive Terminals of Medium-Sized Spiny Neurons Selectively Form Synapses with Cholinergic Interneurons in the Rat Neostriatum.” <i>Journal of Comparative Neurology</i>. Wiley-Blackwell, 2007. <a href=\"https://doi.org/10.1002/cne.21216\">https://doi.org/10.1002/cne.21216</a>.","ama":"Kuramoto E, Fujiyama F, Unzai T, et al. Metabotropic glutamate receptor 4-immunopositive terminals of medium-sized spiny neurons selectively form synapses with cholinergic interneurons in the rat neostriatum. <i>Journal of Comparative Neurology</i>. 2007;500(5):908-922. doi:<a href=\"https://doi.org/10.1002/cne.21216\">10.1002/cne.21216</a>","short":"E. Kuramoto, F. Fujiyama, T. Unzai, K. Nakamura, H. Hioki, T. Furuta, R. Shigemoto, F. Ferraguti, T. Kaneko, Journal of Comparative Neurology 500 (2007) 908–922.","mla":"Kuramoto, Eriko, et al. “Metabotropic Glutamate Receptor 4-Immunopositive Terminals of Medium-Sized Spiny Neurons Selectively Form Synapses with Cholinergic Interneurons in the Rat Neostriatum.” <i>Journal of Comparative Neurology</i>, vol. 500, no. 5, Wiley-Blackwell, 2007, pp. 908–22, doi:<a href=\"https://doi.org/10.1002/cne.21216\">10.1002/cne.21216</a>.","ieee":"E. Kuramoto <i>et al.</i>, “Metabotropic glutamate receptor 4-immunopositive terminals of medium-sized spiny neurons selectively form synapses with cholinergic interneurons in the rat neostriatum,” <i>Journal of Comparative Neurology</i>, vol. 500, no. 5. Wiley-Blackwell, pp. 908–922, 2007."},"publication_status":"published","date_published":"2007-02-10T00:00:00Z","abstract":[{"lang":"eng","text":"Metabotropic glutamate receptor 4 (mGluR4) is localized mainly to presynaptic membranes in the brain. Rat neostriatum has been reported to contain two types of mGluR4-immunoreactive axon varicosities: small, weakly immunoreactive varicosities that were distributed randomly (type 1) and large, intensely immunoreactive ones that were often aligned linearly (type 2). In the present study, most type 1 terminals formed asymmetric synapses on dendritic spines, whereas type 2 terminals made symmetric synapses on dendritic shafts, showing immunoreactivity for GABAergic markers. After depletion of neostriatal neurons, type 2 but not type 1 varicosities were largely decreased in the damaged region. When medium-sized spiny neurons (MSNs) were labeled with Sindbis virus expressing membrane-targeted green fluorescent protein, mGluR4 immunoreactivity was observed on some varicosities of their axon collaterals in immunofluorescence and immunoelectron microscopies. Furthermore, type 2 varicosities were often positive for substance P but mostly negative for striatal interneuron markers and preproenkephalin. Thus, striatonigral/striato- entopeduncular MSNs are likely to be the largest source of type 2 mGluR4-immunopositive axon terminals in the neostriatum. Next, in the double-immunofluorescence study, almost all choline acetyltransferase (ChAT)-immunopositive and 41% of NK1 receptor-positive dendrites were heavily associated with type 2 mGluR4-immunoreactive varicosities. Neuronal nitric oxide synthase (nNOS)-positive dendrites, in contrast, seemed associated with only a few type 2 varicosities. Conversely, almost all type 2 varicosities were closely apposed to NK1 receptor-positive dendrites that were known to be derived from cholinergic and nNOS-producing interneurons. These findings indicate that the mGluR4-positive terminals of MSN axon collaterals selectively form synapses with neostriatal cholinergic interneurons."}],"_id":"2495","day":"10","publication":"Journal of Comparative Neurology","author":[{"last_name":"Kuramoto","first_name":"Eriko","full_name":"Kuramoto, Eriko"},{"full_name":"Fujiyama, Fumino","last_name":"Fujiyama","first_name":"Fumino"},{"last_name":"Unzai","first_name":"Tomo","full_name":"Unzai, Tomo"},{"first_name":"Kouichi","last_name":"Nakamura","full_name":"Nakamura, Kouichi"},{"full_name":"Hioki, Hiroyuki","first_name":"Hiroyuki","last_name":"Hioki"},{"full_name":"Furuta, Takahiro","last_name":"Furuta","first_name":"Takahiro"},{"orcid":"0000-0001-8761-9444","full_name":"Ryuichi Shigemoto","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","first_name":"Ryuichi","last_name":"Shigemoto"},{"last_name":"Ferraguti","first_name":"Francesco","full_name":"Ferraguti, Francesco"},{"full_name":"Kaneko, Takeshi","last_name":"Kaneko","first_name":"Takeshi"}],"page":"908 - 922","doi":"10.1002/cne.21216","type":"journal_article","date_updated":"2021-01-12T06:57:49Z","month":"02"}