{"type":"journal_article","has_accepted_license":"1","date_updated":"2021-01-12T06:57:40Z","volume":23,"abstract":[{"lang":"eng","text":"Cadherins are transmembrane proteins that mediate cell–cell adhesion in animals. By regulating contact formation and stability, cadherins play a crucial role in tissue morphogenesis and homeostasis. Here, we review the three major  unctions of cadherins in cell–cell contact formation and stability. Two of those functions lead to a decrease in interfacial ension at the forming cell–cell contact, thereby promoting contact expansion — first, by providing adhesion tension that lowers interfacial tension at the cell–cell contact, and second, by signaling to the actomyosin cytoskeleton in order to reduce cortex tension and thus interfacial tension at the contact. The third function of cadherins in cell–cell contact formation is to stabilize the contact by resisting mechanical forces that pull on the contact."}],"publication":"Current Biology","publication_status":"published","_id":"2469","author":[{"id":"48F1E0D8-F248-11E8-B48F-1D18A9856A87","last_name":"Maître","orcid":"0000-0002-3688-1474","full_name":"Maître, Jean-Léon","first_name":"Jean-Léon"},{"orcid":"0000-0002-0912-4566","first_name":"Carl-Philipp J","full_name":"Heisenberg, Carl-Philipp J","id":"39427864-F248-11E8-B48F-1D18A9856A87","last_name":"Heisenberg"}],"doi":"10.1016/j.cub.2013.06.019","month":"07","date_created":"2018-12-11T11:57:51Z","citation":{"chicago":"Maître, Jean-Léon, and Carl-Philipp J Heisenberg. “Three Functions of Cadherins in Cell Adhesion.” <i>Current Biology</i>. Cell Press, 2013. <a href=\"https://doi.org/10.1016/j.cub.2013.06.019\">https://doi.org/10.1016/j.cub.2013.06.019</a>.","ista":"Maître J-L, Heisenberg C-PJ. 2013. Three functions of cadherins in cell adhesion. Current Biology. 23(14), R626–R633.","apa":"Maître, J.-L., &#38; Heisenberg, C.-P. J. (2013). Three functions of cadherins in cell adhesion. <i>Current Biology</i>. Cell Press. <a href=\"https://doi.org/10.1016/j.cub.2013.06.019\">https://doi.org/10.1016/j.cub.2013.06.019</a>","short":"J.-L. Maître, C.-P.J. Heisenberg, Current Biology 23 (2013) R626–R633.","mla":"Maître, Jean-Léon, and Carl-Philipp J. Heisenberg. “Three Functions of Cadherins in Cell Adhesion.” <i>Current Biology</i>, vol. 23, no. 14, Cell Press, 2013, pp. R626–33, doi:<a href=\"https://doi.org/10.1016/j.cub.2013.06.019\">10.1016/j.cub.2013.06.019</a>.","ama":"Maître J-L, Heisenberg C-PJ. Three functions of cadherins in cell adhesion. <i>Current Biology</i>. 2013;23(14):R626-R633. doi:<a href=\"https://doi.org/10.1016/j.cub.2013.06.019\">10.1016/j.cub.2013.06.019</a>","ieee":"J.-L. Maître and C.-P. J. Heisenberg, “Three functions of cadherins in cell adhesion,” <i>Current Biology</i>, vol. 23, no. 14. Cell Press, pp. R626–R633, 2013."},"department":[{"_id":"CaHe"}],"oa":1,"file_date_updated":"2020-07-14T12:45:41Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","ddc":["570"],"external_id":{"pmid":["23885883"]},"status":"public","page":"R626 - R633","language":[{"iso":"eng"}],"file":[{"content_type":"application/pdf","file_size":247320,"date_created":"2019-01-24T15:40:22Z","checksum":"6a424b2f007b41d4955a9135793b2162","access_level":"open_access","file_name":"2013_CurrentBiology_Maitre.pdf","relation":"main_file","creator":"dernst","file_id":"5881","date_updated":"2020-07-14T12:45:41Z"}],"intvolume":"        23","publist_id":"4433","oa_version":"Published Version","issue":"14","scopus_import":1,"quality_controlled":"1","title":"Three functions of cadherins in cell adhesion","pmid":1,"date_published":"2013-07-22T00:00:00Z","day":"22","tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"publisher":"Cell Press","year":"2013"}