{"title":"Progress and prospects toward our understanding of the evolution of dosage compensation","quality_controlled":0,"author":[{"id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87","last_name":"Vicoso","orcid":"0000-0002-4579-8306","first_name":"Beatriz","full_name":"Beatriz Vicoso"},{"full_name":"Bachtrog, Doris","first_name":"Doris","last_name":"Bachtrog"}],"doi":"10.1007/s10577-009-9053-y","_id":"2070","abstract":[{"lang":"eng","text":"In many eukaryotic organisms, gender is determined by a pair of heteromorphic sex chromosomes. Degeneration of the non-recombining Y chromosome is a general facet of sex chromosome evolution. Selective pressure to restore expression levels of X-linked genes relative to autosomes accompanies Y-chromosome degeneration, thus driving the evolution of dosage compensation mechanisms. This review focuses on evolutionary aspects of dosage compensation, in light of recent advances in comparative and functional genomics that have substantially increased our understanding of the molecular mechanisms of dosage compensation and how it evolved. We review processes involved in sex chromosome evolution, and discuss the dynamic interaction between Y degeneration and the acquisition of dosage compensation. We compare mechanisms of dosage compensation and the origin of dosage compensation genes between different taxa and comment on sex chromosomes that apparently lack compensation mechanisms. Finally, we discuss how dosage compensation systems can also influence the evolution of well-established sex chromosomes."}],"publication_status":"published","publication":"Chromosome Research","issue":"5","type":"journal_article","extern":1,"volume":17,"publist_id":"4969","date_updated":"2021-01-12T06:55:07Z","intvolume":"        17","day":"01","page":"585 - 602","publisher":"Springer","status":"public","year":"2009","date_published":"2009-07-01T00:00:00Z","acknowledgement":"This research is funded by NIH Grant GM076007 and a Sloan Research Fellowship and a David and Lucile Packard Fellowship to D.B.","date_created":"2018-12-11T11:55:32Z","month":"07","citation":{"apa":"Vicoso, B., &#38; Bachtrog, D. (2009). Progress and prospects toward our understanding of the evolution of dosage compensation. <i>Chromosome Research</i>. Springer. <a href=\"https://doi.org/10.1007/s10577-009-9053-y\">https://doi.org/10.1007/s10577-009-9053-y</a>","chicago":"Vicoso, Beatriz, and Doris Bachtrog. “Progress and Prospects toward Our Understanding of the Evolution of Dosage Compensation.” <i>Chromosome Research</i>. Springer, 2009. <a href=\"https://doi.org/10.1007/s10577-009-9053-y\">https://doi.org/10.1007/s10577-009-9053-y</a>.","ista":"Vicoso B, Bachtrog D. 2009. Progress and prospects toward our understanding of the evolution of dosage compensation. Chromosome Research. 17(5), 585–602.","ieee":"B. Vicoso and D. Bachtrog, “Progress and prospects toward our understanding of the evolution of dosage compensation,” <i>Chromosome Research</i>, vol. 17, no. 5. Springer, pp. 585–602, 2009.","ama":"Vicoso B, Bachtrog D. Progress and prospects toward our understanding of the evolution of dosage compensation. <i>Chromosome Research</i>. 2009;17(5):585-602. doi:<a href=\"https://doi.org/10.1007/s10577-009-9053-y\">10.1007/s10577-009-9053-y</a>","mla":"Vicoso, Beatriz, and Doris Bachtrog. “Progress and Prospects toward Our Understanding of the Evolution of Dosage Compensation.” <i>Chromosome Research</i>, vol. 17, no. 5, Springer, 2009, pp. 585–602, doi:<a href=\"https://doi.org/10.1007/s10577-009-9053-y\">10.1007/s10577-009-9053-y</a>.","short":"B. Vicoso, D. Bachtrog, Chromosome Research 17 (2009) 585–602."}}