{"intvolume":"        68","type":"journal_article","extern":1,"volume":68,"publist_id":"4970","date_updated":"2021-01-12T06:55:06Z","abstract":[{"lang":"eng","text":"In Drosophila, there is a consistent deficit of male-biased genes on the X chromosome. It has been suggested that male-biased genes may evolve from initially unbiased genes as a result of increased expression levels in males. If transcription rates are limited, a large increase in expression in the testis may be harder to achieve for single-copy X-linked genes than for autosomal genes, because they are already hypertranscribed due to dosage compensation. This hypothesis predicts that the larger the increase in expression required to make a male-biased gene, the lower the chance of this being achievable if it is located on the X chromosome. Consequently, highly expressed male-biased genes should be located on the X chromosome less often than lowly expressed male-biased genes. This pattern is observed in our analysis of publicly available data, where microarray data or EST data are used to detect male-biased genes in D. melanogaster and to measure their expression levels. This is consistent with the idea that limitations in transcription rates may prevent male-biased genes from accumulating on the X chromosome."}],"issue":"5","publication":"Journal of Molecular Evolution","publication_status":"published","title":"The deficit of male-biased genes on the D. melanogaster X chromosome is expression-dependent: A consequence of dosage compensation?","quality_controlled":0,"author":[{"id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87","last_name":"Vicoso","orcid":"0000-0002-4579-8306","full_name":"Beatriz Vicoso","first_name":"Beatriz"},{"last_name":"Charlesworth","first_name":"Brian","full_name":"Charlesworth, Brian"}],"doi":"10.1007/s00239-009-9235-4","_id":"2068","date_created":"2018-12-11T11:55:31Z","month":"05","citation":{"apa":"Vicoso, B., &#38; Charlesworth, B. (2009). The deficit of male-biased genes on the D. melanogaster X chromosome is expression-dependent: A consequence of dosage compensation? <i>Journal of Molecular Evolution</i>. Springer. <a href=\"https://doi.org/10.1007/s00239-009-9235-4\">https://doi.org/10.1007/s00239-009-9235-4</a>","chicago":"Vicoso, Beatriz, and Brian Charlesworth. “The Deficit of Male-Biased Genes on the D. Melanogaster X Chromosome Is Expression-Dependent: A Consequence of Dosage Compensation?” <i>Journal of Molecular Evolution</i>. Springer, 2009. <a href=\"https://doi.org/10.1007/s00239-009-9235-4\">https://doi.org/10.1007/s00239-009-9235-4</a>.","ista":"Vicoso B, Charlesworth B. 2009. The deficit of male-biased genes on the D. melanogaster X chromosome is expression-dependent: A consequence of dosage compensation? Journal of Molecular Evolution. 68(5), 576–583.","ieee":"B. Vicoso and B. Charlesworth, “The deficit of male-biased genes on the D. melanogaster X chromosome is expression-dependent: A consequence of dosage compensation?,” <i>Journal of Molecular Evolution</i>, vol. 68, no. 5. Springer, pp. 576–583, 2009.","short":"B. Vicoso, B. Charlesworth, Journal of Molecular Evolution 68 (2009) 576–583.","ama":"Vicoso B, Charlesworth B. The deficit of male-biased genes on the D. melanogaster X chromosome is expression-dependent: A consequence of dosage compensation? <i>Journal of Molecular Evolution</i>. 2009;68(5):576-583. doi:<a href=\"https://doi.org/10.1007/s00239-009-9235-4\">10.1007/s00239-009-9235-4</a>","mla":"Vicoso, Beatriz, and Brian Charlesworth. “The Deficit of Male-Biased Genes on the D. Melanogaster X Chromosome Is Expression-Dependent: A Consequence of Dosage Compensation?” <i>Journal of Molecular Evolution</i>, vol. 68, no. 5, Springer, 2009, pp. 576–83, doi:<a href=\"https://doi.org/10.1007/s00239-009-9235-4\">10.1007/s00239-009-9235-4</a>."},"acknowledgement":"This work was funded by a Portuguese Foundation for Science and Technology scholarship to B.V., and B.C. was supported by the Royal Society","date_published":"2009-05-01T00:00:00Z","day":"01","page":"576 - 583","year":"2009","status":"public","publisher":"Springer"}