{"abstract":[{"lang":"eng","text":"Development requires tissue growth as well as cell diversification. To address how these processes are coordinated, we analyzed the development of molecularly distinct domains of neural progenitors in the mouse and chick neural tube. We show that during development, these domains undergo changes in size that do not scale with changes in overall tissue size. Our data show that domain proportions are first established by opposing morphogen gradients and subsequently controlled by domain-specific regulation of differentiation rate but not differences in proliferation rate. Regulation of differentiation rate is key to maintaining domain proportions while accommodating both intra- and interspecies variations in size. Thus, the sequential control of progenitor specification and differentiation elaborates pattern without requiring that signaling gradients grow as tissues expand. "}],"main_file_link":[{"open_access":"1","url":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4228193/"}],"_id":"2040","article_number":"1254927","department":[{"_id":"ToBo"}],"language":[{"iso":"eng"}],"issue":"6204","date_published":"2014-09-26T00:00:00Z","publication_status":"published","citation":{"ama":"Kicheva A, Bollenbach MT, Ribeiro A, et al. Coordination of progenitor specification and growth in mouse and chick spinal cord. <i>Science</i>. 2014;345(6204). doi:<a href=\"https://doi.org/10.1126/science.1254927\">10.1126/science.1254927</a>","ista":"Kicheva A, Bollenbach MT, Ribeiro A, Pérez Valle H, Lovell Badge R, Episkopou V, Briscoe J. 2014. Coordination of progenitor specification and growth in mouse and chick spinal cord. Science. 345(6204), 1254927.","chicago":"Kicheva, Anna, Mark Tobias Bollenbach, Ana Ribeiro, Helena Pérez Valle, Robin Lovell Badge, Vasso Episkopou, and James Briscoe. “Coordination of Progenitor Specification and Growth in Mouse and Chick Spinal Cord.” <i>Science</i>. American Association for the Advancement of Science, 2014. <a href=\"https://doi.org/10.1126/science.1254927\">https://doi.org/10.1126/science.1254927</a>.","apa":"Kicheva, A., Bollenbach, M. T., Ribeiro, A., Pérez Valle, H., Lovell Badge, R., Episkopou, V., &#38; Briscoe, J. (2014). Coordination of progenitor specification and growth in mouse and chick spinal cord. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.1254927\">https://doi.org/10.1126/science.1254927</a>","short":"A. Kicheva, M.T. Bollenbach, A. Ribeiro, H. Pérez Valle, R. Lovell Badge, V. Episkopou, J. Briscoe, Science 345 (2014).","mla":"Kicheva, Anna, et al. “Coordination of Progenitor Specification and Growth in Mouse and Chick Spinal Cord.” <i>Science</i>, vol. 345, no. 6204, 1254927, American Association for the Advancement of Science, 2014, doi:<a href=\"https://doi.org/10.1126/science.1254927\">10.1126/science.1254927</a>.","ieee":"A. Kicheva <i>et al.</i>, “Coordination of progenitor specification and growth in mouse and chick spinal cord,” <i>Science</i>, vol. 345, no. 6204. American Association for the Advancement of Science, 2014."},"date_updated":"2021-01-12T06:54:55Z","month":"09","publication":"Science","author":[{"full_name":"Kicheva, Anna","first_name":"Anna","last_name":"Kicheva"},{"orcid":"0000-0003-4398-476X","full_name":"Bollenbach, Mark Tobias","id":"3E6DB97A-F248-11E8-B48F-1D18A9856A87","first_name":"Mark Tobias","last_name":"Bollenbach"},{"last_name":"Ribeiro","first_name":"Ana","full_name":"Ribeiro, Ana"},{"full_name":"Pérez Valle, Helena","last_name":"Pérez Valle","first_name":"Helena"},{"first_name":"Robin","last_name":"Lovell Badge","full_name":"Lovell Badge, Robin"},{"last_name":"Episkopou","first_name":"Vasso","full_name":"Episkopou, Vasso"},{"first_name":"James","last_name":"Briscoe","full_name":"Briscoe, James"}],"day":"26","doi":"10.1126/science.1254927","type":"journal_article","status":"public","title":"Coordination of progenitor specification and growth in mouse and chick spinal cord","quality_controlled":"1","scopus_import":1,"year":"2014","publisher":"American Association for the Advancement of Science","user_id":"4435EBFC-F248-11E8-B48F-1D18A9856A87","publist_id":"5011","volume":345,"date_created":"2018-12-11T11:55:22Z","intvolume":"       345","oa_version":"Submitted Version","oa":1}